Benefits and safety of hepatic resection for colorectal metastases

Harmon, Kurt E; Ryan, John A.; Biehl, Thomas; Lee, Faye T.

doi:10.1016/s0002-9610(99)00070-7

Cited by 93 publications

(58 citation statements)

References 6 publications

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“…The reason for the different survival times between both groups may be due to the aggressiveness of original carcinoma cells. Although there is no report comparing the prognosis of metastases from stomach and colon carcinoma, several reports have shown that patients with advanced and recurrent colon carcinoma had a better prognosis than those with gastric carcinoma [16, 17, 18, 19, 20]. The prognosis of secondary ovarian carcinomas with respect to the primary tumor site, has not been reported previously, and our data suggest that the primary site might be an important prognostic factor.…”

Section: Discussioncontrasting

confidence: 51%

Prognostic Factors of Secondary Ovarian Carcinoma

Kikkawa

Ino²,

Nomura³

et al. 2002

Oncology

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Objective: Although the ovaries are common sites of metastases from a variety of primary neoplasms excluding carcinomas of the genital tract, there were few reports concerning survival and prognostic factors. The objective of this study was to assess the clinical factors affecting survival. Methods: Fifty-three secondary ovarian carcinomas excluding metastases from genital tract carcinoma were registered by the Tokai Ovarian Tumor Study Group from 1989 to 1999. FIGO staging was set without considering the pathologic findings of the lymph nodes and the primary tumors. Results: Twenty-four patients were stage I, 11 were stage II, 16 were stage III, and 2 were stage IV. There were significant differences in the survival curves between the early stages (I and II) and advanced stages (III and IV). The 5-year survival rate for patients without residual tumors was 39.9%, while all patients with residual tumors after surgery died within 33 months. The most frequent primary tumor was large intestinal carcinoma, and the second was gastric carcinoma. The 5-year survival rate for patients with large intestinal primary tumors was significantly better than that with stomach tumors. Multivariate analysis demonstrated that tumor stage and primary tumor sites were significant prognostic factors. Conclusion: FIGO staging without considering lymph node involvement and the primary tumor was a significant prognostic factor, and prognostic factors for primary ovarian carcinomas can be applied to secondary ovarian carcinomas. Furthermore, the primary tumor site was also an important prognostic factor for survival.

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Section: Discussioncontrasting

confidence: 51%

Prognostic Factors of Secondary Ovarian Carcinoma

Kikkawa

Ino²,

Nomura³

et al. 2002

Oncology

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“…Detecting recurrent disease is only useful if early treatment leads to an improved prognosis. Although the majority of relapsing patients are incurable, around one third of patients with isolated distant or locoregional recurrence are alive at 5 years after treatment, and long-term survival is possible [21,[23][24][25][26][27][28][29][30][31][32][33] . Rates of resection for isolated or limited disease recurrence have increased, and approximately 20% of patients with hepatic relapse are currently considered for surgery [24,32,34] .…”

Section: Introductionmentioning

confidence: 99%

Surveillance of patients following surgery with curative intent for colorectal cancer

Gan

Wilson²,

Hollington³

2007

WJG

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Surveillance after resection of colorectal cancer with curative intent is an important component of postoperative care. Clinical review, imaging, colonoscopy, and cost to the community are among significant issues to consider in planning a surveillance regime. This review aims to identify the available evidence for the use of surveillance and its individual components. The literature pertaining to follow-up of patients following potentially curative surgery for colorectal cancer was reviewed in order to formulate a summary of the wide range of clinical practice. There is evidence of improved survival of patients undergoing more intense follow-up compared with those having minimal surveillance, with an estimated overall 5-year gain of up to 10%. The efficacy of individual components of follow-up regimes remains unclear, but an overall package of 'intensive' follow-up including clinical review, liver imaging, and colonoscopy appears to be of benefit. It is cost-effective and can be specialist or community-based.

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“…Surgical resection of liver and lung metastases may be more effective than resection of recurrences at other sites. The reported 5-year survival rate following resection of liver or lung metastases ranges from 30 to 50% [1,2,3,4,5,6,7]. …”

Section: Discussionmentioning

confidence: 99%

“…Many reports have suggested that resection of metastatic recurrences may provide survival benefits for patients who have undergone curative resection of colorectal cancer [1,2,3,4,5,6,7]. Hepatic and pulmonary metastases are known to be common and provide good indications for metastasectomy, as do brain, spinal, and peritoneal metastases.…”

Section: Introductionmentioning

confidence: 99%

Multiple Repeat Metastasectomies for Recurrences of Colorectal Cancer

Ajisaka¹

2008

Dig Surg

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Background/Aim: The disease-free interval after resection of the primary tumour was found to be an independent significant prognostic factor for single repeat metastasectomy for colorectal cancer. In the present study, the intervals from resection to relapse for multiple repeat metastasectomies were evaluated. Methods: Sixteen patients who underwent multiple repeat metastasectomies after the first curative resection were studied to determine whether their intervals from resection to relapse were associated with the prognosis. Results: The patients could be classified into three types by the intervals from resection to relapse: (1) the intervals of 4 patients between recurrences were constant and lasted a few years (long-term regular-type group); (2) those of 6 patients were almost constant between recurrences and lasted about 1 year (short-term regular-type group), and (3) the intervals of 6 patients became shorter with each recurrence (shortening-type group). 3 of the 4 patients in the long-term regular-type group, 2 of the 6 patients in the short-term regular-type group, and none of the 6 patients in the shortening-type group are currently alive without recurrence. The survival rate was significantly higher in the long-term regular-type group than in the shortening-type group. Conclusion: For patients with constant intervals of relapse, achieving curative resection is the most relevant prognostic factor for a favourable prognosis after repeat metastasectomies for recurrence of colorectal cancer.

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Benefits and safety of hepatic resection for colorectal metastases

Cited by 93 publications

References 6 publications

Prognostic Factors of Secondary Ovarian Carcinoma

Prognostic Factors of Secondary Ovarian Carcinoma

Surveillance of patients following surgery with curative intent for colorectal cancer

Multiple Repeat Metastasectomies for Recurrences of Colorectal Cancer

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