Benefits and risks of antimicrobial use in food-producing animals

Hao, Haihong; Cheng, Guyue; Zahid, Iqbal; Ai, Xiaohui; Hussain, Hamid; Huang, Lingli; Dai, Menghong; Wang, Yulian; Liu, Zhenli; Zhang, Yuan

doi:10.3389/fmicb.2014.00288

Cited by 303 publications

(202 citation statements)

References 100 publications

(132 reference statements)

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“…The term 'antibiotic growth promoter' is used to define any agent that either destroys or inhibits bacteria when administered at a small, sub-therapeutic dose (Hao et al, 2014). The greater use of several antibiotics for growth promotion purpose has arisen due to the popularity and necessity of poultry farming.…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of body weight and serum biochemistry in broilers supplemented with some selected probiotics and antibiotic growth promoters

2017

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Objective: The present work was conducted on Cobb-500 broilers fed with either probiotics (Yogurt, Promax ® ) or antibiotic growth promoters (Ciproflox ® , Renamycin ® ) to assess the effects on body weight and biochemical parameters. Materials and methods: A total of 30 day-old broiler chicks were purchased and acclimatized for 7 days in the experimental shed. After initial acclimatization, the broilers were allotted into five equal groups (n=6). Group A was considered as control and was fed commercial ration and fresh drinking water. Groups B and C were fed commercial ration and probiotics (Yogurt, Promax ® ) respectively mixed in water. Groups D and E received commercial ration and antibiotic growth promoters (Ciproflox ® , Renamycin ® ) respectively with water. Body weight of each bird was recorded on day 7, 14, 21, 28 and 35. At the end of trial period, the birds were sacrificed to collect blood in order to prepare serum samples for biochemical analyses considering total cholesterol, triglyceride, high density lipids (HDL), creatinine, alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Results: Body weight in all treatment groups (B, C, D and E) was significantly (P<0.05) higher as compared to control (A) group. Total cholesterol and triglyceride levels significantly (P<0.05) decreased in probiotics treated groups as compared to control and antibiotic growth promoters treated groups. AST and ALT values increased significantly (P<0.05) in antibiotic growth promoters treated groups as compared to control whereas, these values decreased in probiotics treated groups. Creatinine levels were significantly (P<0.05) higher in antibiotic growth promoters treated groups as compared to all others groups. Conclusion: Significantly increased body weight is observed in probiotics and antibiotic growth promoters supplemented broilers. Probiotics also improve the lipid profile and other biochemical parameters as compared to growth promoter. Probiotics (like Yogurt and Promax ® ) seem to be better choice than antibiotic growth promoters as feed supplements.

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Section: Introductionmentioning

confidence: 99%

Comparative analysis of body weight and serum biochemistry in broilers supplemented with some selected probiotics and antibiotic growth promoters

2017

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“…There are studies that cover a range of issues including but not limited to the uncertainties about the use of antibiotics in food animals and the risk posed to human health [62,63]; the epidemiological and molecular evidence for the spread of resistance from food animals to man [53,60,61,64]; and the benefits and risks of antimicrobial use in food-producing animals [65,66]. Despite the numerous studies focused on these issues, the WHO surveillance report (2014) indicated that there are major gaps associated with the surveillance and sharing of data around resistance in foodborne bacteria and its relationship with animal and human health [4].…”

Section: Food Safetymentioning

confidence: 99%

“…Despite the numerous studies focused on these issues, the WHO surveillance report (2014) indicated that there are major gaps associated with the surveillance and sharing of data around resistance in foodborne bacteria and its relationship with animal and human health [4]. The benefits and risks of the use of antibiotics in the food animals remain a complex issue, and present a major challenge, and appear to be a double-edged sword [66]. This section touches briefly on some of the continued challenges for food safety.…”

Section: Food Safetymentioning

confidence: 99%

Understanding the contribution of environmental factors in the spread of antimicrobial resistance

Fletcher-Lartey

2015

Environ Health Prev Med

214

131

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The overuse and abuse of antibiotics have contributed to the global epidemic of antibiotic resistance. Current evidence suggests that widespread dependency on antibiotics and complex interactions between human health, animal husbandry and veterinary medicine, have contributed to the propagation and spread of resistant organisms. The lack of information on pathogens of major public health importance, limited surveillance, and paucity of standards for a harmonised and coordinated approach, further complicates the issue. Despite the widespread nature of antimicrobial resistance, limited focus has been placed on the role of environmental factors in propagating resistance. There are limited studies that examine the role of the environment, specifically water, sanitation and hygiene factors that contribute to the development of resistant pathogens. Understanding these elements is necessary to identify any modifiable interactions to reduce or interrupt the spread of resistance from the environment into clinical settings. This paper discusses some environmental issues that contribute to antimicrobial resistance, including soil related factors, animal husbandry and waste management, potable and wastewater, and food safety, with examples drawn mainly from the Asian region. The discussion concludes that some of the common issues are often overlooked and whilst there are numerous opportunities for environmental factors to contribute to the growing burden of antimicrobial resistance, a renewed focus on innovative and traditional environmental approaches is needed to tackle the problem.

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“…Enrofloxacin and its active metabolite Ciprofloxacin, fluoroquinolone antibiotic, which have been approved for use in food animals and are effective against organisms resistant to commonly used antibiotics in veterinary medicine such as β-lactams, aminoglycosides, tetracyclines and macrolides (Hao et al, 2014). Drug residues may pass on to tissues and milk due to extra label use of these antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Screening of Enrofloxacin and Its Metabolite Ciprofloxacin Residues by High-Performance Liquid Chromatography in Cow Milk of District Udham Singh Nagar, Uttarakhand

Srinivasu¹,

Ahmad²,

Kumar³

et al. 2017

Int. J. Livest. Res.

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Benefits and risks of antimicrobial use in food-producing animals

Cited by 303 publications

References 100 publications

Comparative analysis of body weight and serum biochemistry in broilers supplemented with some selected probiotics and antibiotic growth promoters

Comparative analysis of body weight and serum biochemistry in broilers supplemented with some selected probiotics and antibiotic growth promoters

Understanding the contribution of environmental factors in the spread of antimicrobial resistance

Screening of Enrofloxacin and Its Metabolite Ciprofloxacin Residues by High-Performance Liquid Chromatography in Cow Milk of District Udham Singh Nagar, Uttarakhand

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