Benefits and Risks Associated With Thrombolysis for Pulmonary Embolism

Bradford, Mark A.; Adhikari, Neill K. J.; Friedrich, Jan O.

doi:10.1001/jama.2014.10780

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…Techniques such as catheter-directed thrombolysis or pharmacological thrombolysis have been shown to reduce mortality rates compared to anticoagulation alone, albeit at the expense of increased bleeding risks. Compared to systemic thrombolysis, catheter-directed thrombolysis presents a higher safety pro le [42][43][44] . IVCF may be utilized for patients with a high risk of bleeding or contraindications to anticoagulation.…”

Section: Management Of Vte In Tbi Patientsmentioning

confidence: 99%

A Challenging Case of Anticoagulation: Acute Traumatic Brain Injury Complicated by Multifocal Venous Thromboembolism

Shen,

Ou,

Chen

et al. 2024

Preprint

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Traumatic brain injury (TBI) poses a significant threat to human health and well-being, imposing substantial burdens on patients, families, and society at large. The mechanisms underlying coagulopathy induced by TBI remain elusive. Given the risk of exacerbated intracranial hemorrhage in the early stages of TBI, the initiation of anticoagulant therapy is often deferred. However, TBI is an independent risk factor for venous thromboembolism (VTE), and delaying anticoagulation increases the risk of VTE incidence and mortality. The early risk of hemorrhage and thrombosis presents a considerable challenge to treatment. This paper presents a case study of a 51-year-old male patient in the acute phase of TBI, complicated by extensive pulmonary embolism (PE) and deep vein thrombosis (DVT), treated with the insertion of an inferior vena cava filter (IVCF) followed by complications of IVCF thrombosis. Through this case and a review of relevant literature, we argue that anticoagulant therapy can be considered 7-14 days post-TBI based on individual circumstances. After IVCF placement, attention must be paid to complications, especially IVCF thrombosis.

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Section: Management Of Vte In Tbi Patientsmentioning

confidence: 99%