Benefits and pathologies associated with the inflammatory response

Singh, Pawandeep; Chazaud, Bénédicte

doi:10.1016/j.yexcr.2021.112905

Cited by 7 publications

(5 citation statements)

References 102 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other small macrophage subpopulations that clustered separately were identified as Cd248 M2-like, marked by the expression of Cd248 , Itgae resident macrophages, marked by the expression of both Cd74 and Itgae , and proliferative macrophages, marked by the expression of Mki67 . These findings indicate the complexity of macrophage subpopulations in both dystrophic and severely dystrophic environments and the involvement of dynamic macrophage phenotypes in the pathological process of muscular dystrophy ( Singh and Chazaud, 2021 ). GO analysis of DE-Gs in mdxD2-NSG macrophages showed enriched terms for degradation of the ECM , positive regulation of lipid localization, Abcg1, Plin2, Lpl, Trem2, Spp1 and Mif1, regulation of cytokine production, with upregulated genes such as Acp5, Arg1, Stat1, Mmp12 and Pld3, among others ( Figures 4 D and 4E).…”

Section: Resultsmentioning

confidence: 79%

Single cell sequencing maps skeletal muscle cellular diversity as disease severity increases in dystrophic mouse models

Saleh¹,

Xi²,

Switzler³

et al. 2022

iScience

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 79%

Single cell sequencing maps skeletal muscle cellular diversity as disease severity increases in dystrophic mouse models

Saleh¹,

Xi²,

Switzler³

et al. 2022

iScience

View full text Add to dashboard Cite

“…They stimulate terminal myogenic differentiation and fusion of MuSCs via the secretion of factors (IGF‐1, TGF‐β, GDF3…) (Arnold et al, 2007 ; Lu et al, 2011 ; Saclier et al, 2013 ; Varga, Mounier, Patsalos, et al, 2016 ). Restorative macrophages also promote angiogenesis, they stimulate fibroblastic cells for extracellular matrix (ECM) remodeling and secrete themselves ECM components (e.g., proteoglycans, matricellular proteins and assembly proteins) (Varga, Mounier, Horvath, et al, 2016 , for reviews see Panci & Chazaud, 2021 ; Singh & Chazaud, 2021 ). The kinetics of the inflammatory response is fundamental for the good orchestration of myogenesis and the surrounding supportive biological processes.…”

Section: Macrophages and Skeletal Muscle Regenerationmentioning

confidence: 99%

Role of macrophages during skeletal muscle regeneration and hypertrophy—Implications for immunomodulatory strategies

Bernard

Zavoriti

Pucelle

et al. 2022

Physiological Reports

Self Cite

View full text Add to dashboard Cite

Skeletal muscle is a plastic tissue that regenerates ad integrum after injury and adapts to raise mechanical loading/contractile activity by increasing its mass and/or myofiber size, a phenomenon commonly refers to as skeletal muscle hypertrophy. Both muscle regeneration and hypertrophy rely on the interactions between muscle stem cells and their neighborhood, which include inflammatory cells, and particularly macrophages. This review first summarizes the role of macrophages in muscle regeneration in various animal models of injury and in response to exercise-induced muscle damage in humans. Then, the potential contribution of macrophages to skeletal muscle hypertrophy is discussed on the basis of both animal and human experiments. We also present a brief comparative analysis of the role of macrophages during muscle regeneration versus hypertrophy. Finally, we summarize the current knowledge on the impact of different immunomodulatory strategies, such as heat therapy, cooling, massage, nonsteroidal anti-inflammatory drugs and resolvins, on skeletal muscle regeneration and their potential impact on muscle hypertrophy.

show abstract

“…A plethora of MP-derived factors are critically involved in inflammation and fibrosis of the muscle. It is speculated that the heterogeneous and pathogenic activation of MPs in dystrophic muscle is likely induced by the asynchronous regeneration altered microenvironment but the underlying signaling molecules and cellular sources remain unexplored( 22 ). Evidence from the scRNA-seq profiling also revealed remarkable heterogeneity of FAPs and their correlation with disease severity( 19 ).…”

Section: Introductionmentioning

confidence: 99%

Skeletal Muscle Stem Cells Modulate Niche Function in Duchenne Muscular Dystrophy through YY1-CCL5 Axis

Li,

Sun

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

Stem cell activity is known to be tightly regulated by both intrinsic and extrinsic pathways but less is known about whether and how stem cells modulate their niche microenvironment. Adult skeletal muscle stem cells (MuSCs) are indispensable for muscle regeneration and also tightly regulated by macrophages (MPs) and fibro-adipogenic progenitors (FAPs) in the niche. Deregulated MuSC/MP/FAP interactions and the ensuing inflammation and fibrosis are hallmarks of dystrophic muscle. Here in this study we demonstrate that intrinsic deletion of transcription factor YY1 in MuSCs exacerbates dystrophic pathologies by altering the cellular composition and heterogeneity of MPs and FAPs. Further analysis reveals that the YY1 loss induces the expression of immune genes in MuSCs, including Ccl5. Augmented secretion of CCL5 from MuSCs promotes the recruitment of MPs via CCL5/CCR5 mediated crosstalk, which subsequently hinders the apoptosis and clearance of FAPs through elevated TGFβ1 accumulation. Maraviroc mediated pharmacological blockade of the CCL5/CCR5 axis effectively mitigates muscle dystrophy and improves muscle performance. Lastly, we further demonstrate that YY1 represses Ccl5 transcription in MuSCs by directly binding to its enhancer thus facilitating promoter-enhancer looping. Altogether, our study has demonstrated the previously unappreciated role of MuSCs in actively shaping their niche microenvironment through secreting immunomodulatory cytokines, and has also provided novel insight into the therapeutic intervention of muscle dystrophy.

show abstract

Benefits and pathologies associated with the inflammatory response

Cited by 7 publications

References 102 publications

Single cell sequencing maps skeletal muscle cellular diversity as disease severity increases in dystrophic mouse models

Single cell sequencing maps skeletal muscle cellular diversity as disease severity increases in dystrophic mouse models

Role of macrophages during skeletal muscle regeneration and hypertrophy—Implications for immunomodulatory strategies

Skeletal Muscle Stem Cells Modulate Niche Function in Duchenne Muscular Dystrophy through YY1-CCL5 Axis

Contact Info

Product

Resources

About