Benefits and complications of photodynamic therapy of papillary capillary hemangiomas

Schmidt‐Erfurth, Ursula; Kusserow, C; Barbazetto, Irene; Laqua, H.

doi:10.1016/s0161-6420(02)01059-x

Cited by 150 publications

(118 citation statements)

References 19 publications

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“…[31][32][33] Retinal tumours PDT with verteporfin causes fewer side effects as it offers site-specific tumour destruction while sparing surrounding structures. 26 Moreover, red wavelength has deeper penetration into the haemangioma than laser photocoagulation. 34 Verteporfin has enhanced selectivity for tissues (including murine vascular tumourigenic cell lines) with upregulated lowdensity lipoprotein receptors.…”

Section: Indications and Resultsmentioning

confidence: 99%

“…34 Verteporfin has enhanced selectivity for tissues (including murine vascular tumourigenic cell lines) with upregulated lowdensity lipoprotein receptors. 26 In addition, intravenously injected verteporfin pools within the RCH, offering a site-specific target for PDT. 26 The vascular effects of PDT may include remodelling of the vascular wall with reduced permeability rather than vascular occlusion.…”

Section: Indications and Resultsmentioning

confidence: 99%

“…26 In addition, intravenously injected verteporfin pools within the RCH, offering a site-specific target for PDT. 26 The vascular effects of PDT may include remodelling of the vascular wall with reduced permeability rather than vascular occlusion. 26,34 Retinal capillary haemangioma: For reasons outlined above, several investigators have reported their preliminary experience of treating RCH with PDT.…”

Section: Indications and Resultsmentioning

confidence: 99%

“…[24][25][26] The safety of PDT has been established treatment of choroidal neovascularization because of age-related macular degeneration. 27 …”

Section: General Principlesmentioning

confidence: 99%

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Ocular phototherapy

Singh

2012

Eye

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Phototherapy can be translated to mean 'light or radiant energy-induced treatment.' Lasers have become the exclusive source of light or radiant energy for all applications of phototherapy. Depending on the wavelength, intensity, and duration of exposure, tissues can either absorb the energy (photocoagulation, thermotherapy, and photodynamic therapy (PDT)) or undergo ionization (photodisruption). For phototherapy to be effective, the energy has to be absorbed by tissues or more specifically by naturally occurring pigment (xanthophyll, haemoglobin, and melanin) within them. In tissues or tumours that lack natural pigment, dyes (verteporphin, Visudyne) with narrow absorption spectrum can be injected intravenously that act as focal absorbent of laser energy after they have preferentially localized within the tumour. Ocular phototherapy has broad applications in treatment of ocular tumours. Laser photocoagulation, thermotherapy, and PDT can be delivered with low rates of complications and with ease in the outpatient setting. Review of the current literature suggests excellent results when these treatments are applied for benign tumours, particularly for vascular tumours such as circumscribed choroidal haemangioma. For primary malignant tumours, such as choroidal melanoma, thermotherapy, and PDT do not offer local tumour control rates that are equivalent or higher than those achieved with plaque or proton radiation therapy. However, for secondary malignant tumours (choroidal metastases), thermotherapy and PDT can be applied as a palliative treatment. Greater experience is necessary to fully comprehend risks, comparative benefits, and complication of ocular phototherapy of ocular tumours.

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Section: Indications and Resultsmentioning

confidence: 99%

Section: Indications and Resultsmentioning

confidence: 99%

Section: Indications and Resultsmentioning

confidence: 99%

“…[24][25][26] The safety of PDT has been established treatment of choroidal neovascularization because of age-related macular degeneration. 27 …”

Section: General Principlesmentioning

confidence: 99%

See 2 more Smart Citations

Ocular phototherapy

Singh

2012

Eye

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“…Several case reports of successful treatment of retinal angiomas with PDT have recently been published. [10][11][12] In contrast, intravitreal anti-VEGF therapy is generally disappointing. 13 Treatment of juxtapapillary angiomas carries a risk of marked visual loss so that asymptomatic tumours are observed without treatment.…”

Section: Diagnosis and Managementmentioning

confidence: 99%

Congenital vascular malformations of the retina and choroid

Heimann

Damato

2009

Eye

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Purpose To review recent advances in the diagnosis and treatment of congenital vascular malformations of the retina and choroid. Methods Review of the current literature on retinal haemangioblastoma, racemose haemangiomatosis, retinal cavernous haemangioblastoma, circumscribed choroidal haemangioma, and diffuse choroidal haemangioma. Conclusion The management of patients with congenital vascular lesions of the retina and choroid is advancing rapidly through recent developments in genetic testing, ocular imaging, and treatment. Most are associated with systemic disease, which may be lifethreatening. New therapeutic methods such as Verteporfin photodynamic therapy and antiangiogenic therapy have significantly improved the treatment of retinal and choroidal angiomas and vascular malformations. Ophthalmologists have a major role in detecting and diagnosing these tumours and in providing long-term care in collaboration with a specialist in the field.

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Three Cases of Large Retinal Capillary Hemangiomas Treated With Verteporfin and Photodynamic Therapy

et al. 2005

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Objective: To investigate the efficacy of verteporfin and photodynamic therapy in the treatment of large retinal capillary hemangiomas.Methods: Case reports of 3 patients with large retinal capillary hemangiomas treated with photodynamic therapy using verteporfin. Standard verteporfin dosages (6 mg/m 2 of body surface area) were given. Both standard and modified photodynamic protocols were followed. Modified protocols included shorter verteporfin infusion times and longer light exposure times.Results: Pretreatment best-corrected Snellen visual acuity of the 3 affected eyes were 20/100, 20/50, and 2/200, respectively. All cases had associated exudative retinal detachments involving the macula. Cases 1 and 2 were classic endophytic retinal capillary hemangiomas. Case 3 was a reactive retinal capillary hemangioma. Case 1 had 2 photodynamic therapy treatments, and after 8 months, visual acuity improved to 20/40. Two years after initiating photodynamic therapy, the visual acuity was 20/30 and there was no reperfusion of the hemangioma. Case 2 had 3 photodynamic therapy treatments. The hemangioma was fibrotic, and 20 months after initiating photodynamic therapy visual acuity improved to 20/30. Case 3 had 1 treatment, 11 weeks later and visual acuity improved to 20/400. Four months after treatment, visual acuity returned to counting fingers because of tractional elevation of the macula as the capillary hemangioma fibrosed. Vitrectomy surgery was performed, and choroidal and retinal neovascularization was discovered. Three months after vitrectomy visual acuity was 20/ 400. In cases 1 and 2, the capillary hemangioma ultimately regressed, and the exudative detachment resolved.Conclusions: Verteporfin and photodynamic therapy were effective in achieving closure of large retinal capillary hemangiomas. In all cases, the hemangioma underwent fibrosis with consequent macular puckering due to retinal traction. In all cases, the visual acuity improved.

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Benefits and complications of photodynamic therapy of papillary capillary hemangiomas

Cited by 150 publications

References 19 publications

Ocular phototherapy

Ocular phototherapy

Congenital vascular malformations of the retina and choroid

Three Cases of Large Retinal Capillary Hemangiomas Treated With Verteporfin and Photodynamic Therapy

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