Benefit of insufficient gestational weight gain in obese women with gestational diabetes mellitus: A multicenter study in Portugal

Ferreira, Joana Lima; Voss, Gina; Dória, Mariana; Couto, Adelina Sá; Príncipe, Rosa Maria

doi:10.1016/j.dsx.2021.01.020

Cited by 9 publications

(6 citation statements)

References 25 publications

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“…In the first part, the current study examined changes related to weight and blood glucose. The findings revealed that T2DM can lead to weight loss, which is consistent with previous studies conducted by Ruissen et al 40 , Lewandowska et al 41 , Rami et al 6 , and Ferreira et al 42 . Further, the study established that diabetes can cause a significant increase in blood glucose, which is in line with the studies conducted by Rami et al 6 , Gabbay et al 43 , Bergenstal et al 44 , and Ripsin et al 45 .…”

Section: Discussionsupporting

confidence: 92%

Highlighting the effects of high-intensity interval training on the changes associated with hypertrophy, apoptosis, and histological proteins of the heart of old rats with type 2 diabetes

Rami,

Ahmadi Hekmatikar,

Rahdar

et al. 2024

Sci Rep

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T2DM is known to cause disturbances in glucose homeostasis and negative changes in the heart muscle, while aging and diabetes are recognized risk factors for CVD. Given this, our study aims to investigate a method for controlling and managing CVDs induced by T2DM in elderly populations. To achieve this, we categorized 40 rats into 5 groups, including HAD (n = 8), HA (n = 8), AD (n = 8), AHT (n = 8), and ADT (n = 8). The exercise protocol consisted of eight weeks of HIIT (three sessions per week) performed at 90–95% of maximal speed. Following cardiac tissue extraction, we assessed the levels of IGF-1, PI3K, and AKT proteins using Western blot technique, and analyzed the histopathological variations of the heart tissue using H&E, Sudan Black, and Masson’s trichrome tissue staining. The histological findings from our study demonstrated that T2DM had a significant impact on the development of pathological hypertrophy and fibrosis in the heart tissue of elderly individuals. However, HIIT not only effectively controlled pathological hypertrophy and fibrosis, but also induced physiological hypertrophy in the AHT and ADT groups compared to the HA and AD groups. Results from Sudan Black staining indicated that there was an increase in lipid droplet accumulation in the cytoplasm of cardiomyocytes and their nuclei in the HA and AD groups, while the accumulation of lipid droplets decreased significantly in the AHT and ADT groups. In both the AHT group and the ADT group, a single HIIT session led to a reduction in collagen fiber accumulation and fibrotic frameworks. Our research also revealed that diabetes caused a significant elevation in the levels of IGF-1, PI3K, and AKT proteins, but after eight weeks of HIIT, the levels of these proteins decreased significantly in the training groups. Overall, our findings suggest that HIIT may be a suitable non-pharmacological approach for improving histological and physiological changes in elderly individuals with T2DM. However, we recommend further research to examine the impact of HIIT training on both healthy and diseased elderly populations.

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Section: Discussionsupporting

confidence: 92%

Highlighting the effects of high-intensity interval training on the changes associated with hypertrophy, apoptosis, and histological proteins of the heart of old rats with type 2 diabetes

Rami,

Ahmadi Hekmatikar,

Rahdar

et al. 2024

Sci Rep

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“…A meta-analysis reported that 30, 34, and, 37% of women with GDM had insufficient, adequate, and excessive GWG (which occurred more in pre pregnancy overweight or obese women), respectively ( 62 ). Although GWG is significantly elevated in women with GDM combined with PE ( 23 , 53 ), most studies considered that the overall excess GWG had no independent correlation with the occurrence of PE ( 23 , 36 , 53 , 63 – 65 ); the same result was reported for obese women with GDM ( 66 ). A recent retrospective cohort study of 1,606 women with GDM in China reported different conclusions, after adjusting for maternal age, pre pregnancy BMI, maternal education, in vitro fertilization, fasting, and 2 h glucose, the risk of the total excess GWG developing to PE is 2.06 times; with 2.28 and 2.17 times in the second and third trimesters, respectively ( 67 ).…”

Section: Factors Associated With Occurrence Of Pe In Women With Gdmmentioning

confidence: 90%

“…Recent prospective cohort study in China suggested that a unit increase in GWG level after GDM diagnosis is not related with the occurrence of PE, but in women with excessive GWG before GDM diagnosis, both adequate and excessive GWG after GDM diagnosis increased the incidence of PE ( 69 ). Both insufficient weight gain after diagnosis of GDM and total insufficient GWG are not associated with the occurrence of PE ( 36 , 65 , 67 – 69 ); however, in obese women with GDM, total insufficient GWG is negatively associated with the occurrence of PE ( 66 ). A meta-analysis of GWG and GDM pregnancy outcomes showed that excessive GWG is associated with an increased risk of pregnancy-induced hypertension, but PE was not analyzed separately ( 62 ).…”

Section: Factors Associated With Occurrence Of Pe In Women With Gdmmentioning

confidence: 99%

Gestational Diabetes Mellitus and Preeclampsia: Correlation and Influencing Factors

Yang

2022

Front. Cardiovasc. Med.

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Gestational diabetes mellitus (GDM) and preeclampsia (PE) are common pregnancy complications with similar risk factors and pathophysiological changes. Evidence from previous studies suggests that the incidence of PE is significantly increased in women with GDM, but whether GDM is independently related to the occurrence of PE has remained controversial. GDM complicated by PE further increases perinatal adverse events with greater impact on the future maternal and offspring health. Identify factors associated with PE in women with GDM women, specifically those that are controllable, is important for improving pregnancy outcomes. This paper provides the findings of a review on the correlation between GDM and PE, factors associated with PE in women with GDM, possible mechanisms, and predictive markers. Most studies concluded that GDM is independently associated with PE in singleton pregnancy, and optimizing the treatment and management of GDM can reduce the incidence of PE, which is very helpful to improve pregnancy outcomes.

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“…Given that the risks of LGA and cesarean delivery increased more rapidly with GWG increase in women with GDM than in women without in our study, a lower GWG for women with GDM than for women without might be reasonable. Furthermore, previous studies have found improvements from a lower GWG than the NAM targets on perinatal outcomes in overweight/obese women with GDM [40][41][42][43], but the impact of a lower GWG in normal-weight or underweight women is unknown. Our findings, that the modifying effect also occurred in normal-weight women, indicated that the normal-weight women with GDM may also benefit from a lower GWG.…”

Section: Discussionmentioning

confidence: 99%

Gestational Diabetes Mellitus as an Effect Modifier of the Association of Gestational Weight Gain with Perinatal Outcomes: A Prospective Cohort Study in China

Cheng

Wei

et al. 2022

IJERPH

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The association of gestational weight gain (GWG) with perinatal outcomes seems to differ between women with and without gestational diabetes mellitus (GDM). Whether GDM is an effect-modifier of the association has not been verified. This study aimed to assess the modifying effect of GDM on the association of GWG with perinatal outcomes. Data on 12,128 pregnant women (3013 with GDM and 9115 without GDM) were extracted from a prospective, multicenter, cohort study in China. The associations of total and trimester-specific GWG rates (GWGR) with perinatal outcomes, including small size for gestational age, large size for gestational age (LGA), preterm birth, cesarean delivery, and gestational hypertension disorders, were assessed. The modifying effect of GDM on the association was assessed on both multiplicative and additive scales, as estimated by mixed-effects logistic regression. As a result, total GWGR was associated with all of the perinatal outcomes. GDM modified the association of total GWGR with LGA and cesarean delivery on both scales (all p < 0.05) but did not modify the association with other outcomes. The modifying effect was observed in the third trimester but not in the first or the second trimester. Therefore, maternal GWG is associated with perinatal outcomes, and GDM modifies the association with LGA and cesarean delivery in the third trimester.

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Benefit of insufficient gestational weight gain in obese women with gestational diabetes mellitus: A multicenter study in Portugal

Cited by 9 publications

References 25 publications

Highlighting the effects of high-intensity interval training on the changes associated with hypertrophy, apoptosis, and histological proteins of the heart of old rats with type 2 diabetes

Highlighting the effects of high-intensity interval training on the changes associated with hypertrophy, apoptosis, and histological proteins of the heart of old rats with type 2 diabetes

Gestational Diabetes Mellitus and Preeclampsia: Correlation and Influencing Factors

Gestational Diabetes Mellitus as an Effect Modifier of the Association of Gestational Weight Gain with Perinatal Outcomes: A Prospective Cohort Study in China

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