Benefit from adjuvant radiotherapy according to the number of risk factors in cutaneous squamous cell carcinoma

Pêtre, Adeline; Pommier, P.; Brahmi, T.; Chabaud, Sylvie; King, Sophie; Fayette, Jérôme; Neidhart, Eve-Marie; Amini‐Adlé, Mona

doi:10.1016/j.radonc.2022.01.015

Cited by 3 publications

(1 citation statement)

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“…The utility of RT in adjuvancy in patients with negative surgical margins but poor prognostic features is controversial [109,110]. A recent study by Ruiz et al has shown that RT reduces the risk of local and locoregional recurrences to half in tumors of high T-stage cSCCs (BWH T2b or T3) [111].…”

Section: Radiation Therapymentioning

confidence: 99%

Management of Cutaneous Squamous Cell Carcinoma of the Scalp: The Role of Imaging and Therapeutic Approaches

Verdaguer-Faja,

Toll,

Boada

et al. 2024

Cancers

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Cutaneous squamous cell carcinoma (cSCC) is the second most common subtype of skin cancer. The scalp is one of the most frequently affected locations and is associated with a higher rate of complications, compared to other locations. In addition, it has a characteristic thickness and anatomical structure that may influence both growth pattern and treatment of primary cSCC; while clinical peripheral margins may be easily achieved during the surgery, vertical excision of the tumor is limited by the skull. Despite having a unique anatomy, current guidelines do not contemplate specific recommendations for scalp cSCC, which leads to inconsistent decision-making in multidisciplinary committees when discussing tumors with high risk factors or with close margins. This article provides specific recommendations for the management of patients with scalp cSCC, based on current evidence, as well as those aspects in which evidence is lacking, pointing out possible future lines of research. Topics addressed include epidemiology, clinical presentation and diagnosis, imaging techniques, surgical and radiation treatments, systemic therapy for advanced cases, and follow-up. The primary focus of this review is on management of primary cSCC of the scalp with localized disease, although where relevant, some points about recurrent cSCCs or advanced disease cases are also discussed.

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Section: Radiation Therapymentioning

confidence: 99%