Beneficial role of oleuropein in sepsis-induced myocardial injury. Possible Involvement of GSK-3β/NF-kB pathway

Xing, Conghui; Xu, Li; Yao, Yingjie

doi:10.1590/acb360107

Cited by 11 publications

(13 citation statements)

References 42 publications

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“…The present results are consistent with the prior studies demonstrating that sepsis‐related myocardial dysfunction occurs within 8–24 h of sepsis and is associated with elevated cardiac enzyme levels 44–46 . CLP is one of the widely employed surgical models in experimental research to induce myocardial sepsis 47,48 as it mimics the development of severe sepsis conditions in humans 49 …”

Section: Discussionsupporting

confidence: 91%

“…43 The present results are consistent with the prior studies demonstrating that sepsis-related myocardial dysfunction occurs within 8-24 h of sepsis and is associated with elevated cardiac enzyme levels. [44][45][46] CLP is one of the widely employed surgical models in experimental research to induce myocardial sepsis 47,48 as it mimics the development of severe sepsis conditions in humans. 49 In the present investigation, following 24 h of ligation and puncture, a substantial increase in proinflammatory cytokines including TNF-α and IL-6 levels was observed in the serum of CLP-subjected mice.…”

Section: Discussionmentioning

confidence: 99%

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Exogenous fetuin‐A protects against sepsis‐induced myocardial injury by inhibiting oxidative stress and inflammation in mice

Hassan

Hanifa

Navik

et al. 2023

Fundamemntal Clinical Pharma

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Sepsis‐induced myocardial injury is a consequence of septicemia and is one of the major causes of death in intensive care units. A serum glycoprotein called fetuin‐A is secreted largely by the liver, tongue, placenta, and adipose tissue. Fetuin‐A has a variety of biological and pharmacological properties. The anti‐inflammatory and antioxidant glycoprotein fetuin‐A has shown its efficacy in a number of inflammatory disorders including sepsis. However, its protective role against sepsis‐induced myocardial injury remains elusive. The purpose of this work is to explore the role of fetuin‐A in mouse models of myocardial injury brought on by cecal ligation and puncture (CLP). CLP significantly induced the myocardial injury assessed in terms of elevated myocardial markers (serum CK‐MB, cTnI levels), inflammatory markers (IL‐6, TNF‐α) in the serum, and oxidative stress markers (increased MDA levels and decreased reduced glutathione) in heart tissue homogenate following 24 h of ligation and puncture. Further, hematoxylin and eosin (H&E) staining showed considerable histological alterations in the myocardial tissue of sepsis‐developed mice. Interestingly, fetuin‐A pretreatment (50 and 100 mg/kg) for 4 days before the CLP procedure significantly improved the myocardial injury and was evaluated in perspective of a reduction in the CK‐MB, cTnI levels, IL‐6, and TNF‐α in sepsis‐developed animals. Fetuin‐A pretreatment significantly attenuated the oxidative stress and improved the myocardial morphology in a dose‐dependent manner. The present study provides preliminary evidence that fetuin‐A exerts protection against sepsis‐induced cardiac dysfunction in vivo via suppression of inflammation and oxidative damage.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Exogenous fetuin‐A protects against sepsis‐induced myocardial injury by inhibiting oxidative stress and inflammation in mice

Hassan

Hanifa

Navik

et al. 2023

Fundamemntal Clinical Pharma

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“…Present results suggest that meldonium is able to ameliorate inflammatory reactions following sepsis induction, with the activation of HMGB1/NF-κB signalling as a proposed underlying mechanism. A similar observation was made by Xing et al as they investigated beneficial roles of oleuropein in sepsis-induced myocardial injury [ 44 ]. Therefore, the effects of meldonium on sepsis-related inflammatory changes cannot explain the higher mortality rate observed in the M + S group.…”

Section: Resultssupporting

confidence: 71%

The Effects of a Meldonium Pre-Treatment on the Course of the Faecal-Induced Sepsis in Rats

Đurašević

Ružičić

Lakić

et al. 2021

IJMS

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Sepsis is a life-threatening condition caused by the dysregulated and overwhelming response to infection, accompanied by an exaggerated pro-inflammatory state and lipid metabolism disturbance leading to sequential organ failure. Meldonium is an anti-ischemic and anti-inflammatory agent which negatively interferes with lipid metabolism by shifting energy production from fatty acid oxidation to glycolysis, as a less oxygen-demanding pathway. Thus, we investigated the effects of a four-week meldonium pre-treatment on faecal-induced sepsis in Sprague-Dawley male rats. Surprisingly, under septic conditions, meldonium increased animal mortality rate compared with the meldonium non-treated group. However, analysis of the tissue oxidative status did not provide support for the detrimental effects of meldonium, nor did the analysis of the tissue inflammatory status showing anti-inflammatory, anti-apoptotic, and anti-necrotic effects of meldonium. After performing tissue lipidomic analysis, we concluded that the potential cause of the meldonium harmful effect is to be found in the overall decreased lipid metabolism. The present study underlines the importance of uninterrupted energy production in sepsis, closely drawing attention to the possible harmful effects of lipid-mobilization impairment caused by certain therapeutics. This could lead to the much-needed revision of the existing guidelines in the clinical treatment of sepsis while paving the way for discovering new therapeutic approaches.

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“…Oleuropein also protected in a redox-dependent manner against reperfusion injury in similar studies [ 143 , 144 ]. In animal models, oleuropein prevented myocardial remodeling in heart failure—by inhibiting the angiotensin-converting enzyme [ 145 ], in doxorubicin cardiomyopathy—by modulating nitric oxide synthases and other mechanisms [ 146 ], and in autoimmune myocarditis [ 147 ] and sepsis-induced myocardial injury—by NF-κB inhibition [ 148 ]. Oleuropein and hydroxytyrosol exert antiapoptotic effects on cardiomyocytes by reducing endoplasmic reticulum stress [ 149 ].…”

Section: Resultsmentioning

confidence: 99%

Therapeutic Properties and Use of Extra Virgin Olive Oil in Clinical Nutrition: A Narrative Review and Literature Update

et al. 2022

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Extra virgin olive oil (EVOO) is a cornerstone of the Mediterranean diet (MedD). In this narrative review, we synthesize and illustrate the various characteristics and clinical applications of EVOO and its components—such as oleic acid, hydroxytyrosol, and oleuropein—in the field of clinical nutrition and dietetics. The evidence is split into diet therapy, oleic acid-based enteral nutrition formulations and oral supplementation formulations, oleic acid-based parenteral nutrition, and nutraceutical supplementation of minor components of EVOO. EVOO has diverse beneficial health properties, and current evidence supports the use of whole EVOO in diet therapy and the supplementation of its minor components to improve cardiovascular health, lipoprotein metabolism, and diabetes mellitus in clinical nutrition. Nevertheless, more intervention studies in humans are needed to chisel specific recommendations for its therapeutic use through different formulations in other specific diseases and clinical populations.

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Beneficial role of oleuropein in sepsis-induced myocardial injury. Possible Involvement of GSK-3β/NF-kB pathway

Cited by 11 publications

References 42 publications

Exogenous fetuin‐A protects against sepsis‐induced myocardial injury by inhibiting oxidative stress and inflammation in mice

Exogenous fetuin‐A protects against sepsis‐induced myocardial injury by inhibiting oxidative stress and inflammation in mice

The Effects of a Meldonium Pre-Treatment on the Course of the Faecal-Induced Sepsis in Rats

Therapeutic Properties and Use of Extra Virgin Olive Oil in Clinical Nutrition: A Narrative Review and Literature Update

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