Beneficial Role of Green Plantain [Musa paradisiaca] in the Management of Persistent Diarrhea: A Prospective Randomized Trial

Alvarez-Acosta, Thais; León, C Felipe; Acosta-González, Salvador; Parra-Soto, Haydeé; Cluet-Rodriguez, Isabel; Rossell, Maria Rosario; Colina-Chourio, J

doi:10.1080/07315724.2009.10719768

Cited by 31 publications

(27 citation statements)

References 29 publications

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“…It is well known that diet can have a profound impact on gut motility changes, and we have previously shown in a humanized mouse model that diet-induced motility changes are accompanied by large changes in SCFA profiles within the microbiota (Kashyap et al 2013). How dietary interventions may promote or ameliorate CDAD is currently unknown, though dietary strategies that alter the composition and metabolic capabilities of the microbiota have proven successful against other enteric pathogens (Cummings et al 1996; Ramakrishna et al 2000; Muir et al 2004; Alam et al 2005; Alvarez-Acosta et al 2009; Rabbani et al 2009). Our data demonstrate that dietary change can rewire crossfeeding relationships relevant to pathogen expansion.…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiota-Produced Succinate Promotes C. difficile Infection after Antibiotic Treatment or Motility Disturbance

Ferreyra

Hryckowian

et al. 2014

Cell Host & Microbe

292

298

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Summary Clostridium difficile is a leading cause of antibiotic-associated diarrhea. The mechanisms underlying C. difficile expansion after microbiota disturbance are just emerging. We assessed the gene expression profile of C. difficile within the intestine of gnotobiotic mice to identify genes regulated in response to either dietary or microbiota compositional changes. In the presence of the gut symbiont Bacteroides thetaiotaomicron, C. difficile induces a pathway that metabolizes the microbiota fermentation end-product succinate to butyrate. The low concentration of succinate in the microbiota of conventional mice is transiently elevated upon antibiotic treatment or chemically-induced intestinal motility disturbance, and C. difficile exploits this succinate spike to expand in the perturbed intestine. A C. difficile mutant compromised in succinate utilization is at a competitive disadvantage during these perturbations. Understanding the metabolic mechanisms involved in microbiota-C. difficile interactions may help to identify approaches for the treatment and prevention of C. difficile-associated diseases.

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Section: Discussionmentioning

confidence: 99%

Gut Microbiota-Produced Succinate Promotes C. difficile Infection after Antibiotic Treatment or Motility Disturbance

Ferreyra

Hryckowian

et al. 2014

Cell Host & Microbe

292

298

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“…Such dietary interventions designed to discourage the gut invasion of pathogens have undergone clinical trials recently. 39,40 The increased levels of short-chain fatty acid production by distal gut microbiota that occurs upon enrichment of dietary starch has been proposed to result in an intestinal environment unfavorable to Shigella. 27,39,40 The idea of C. difficile growth control by nutritional alteration is not new and was demonstrated in animal models in the 1980s.…”

Section: Discussionmentioning

confidence: 99%

“…39,40 The increased levels of short-chain fatty acid production by distal gut microbiota that occurs upon enrichment of dietary starch has been proposed to result in an intestinal environment unfavorable to Shigella. 27,39,40 The idea of C. difficile growth control by nutritional alteration is not new and was demonstrated in animal models in the 1980s. 28,41 Therefore, our results showing that C. difficile strains have a high propensity to use easily metabolizable sugars and peptides are in agreement with these previous studies.…”

Section: Discussionmentioning

confidence: 99%

Comparative nutritional and chemical phenome of Clostridium difficile isolates determined using phenotype microarrays

Scaria

Chen

Useh

et al. 2014

International Journal of Infectious Diseases

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Summary Objectives Clostridium difficile infection (CDI) is the leading cause of infectious diarrhea in North America and Europe. The risk of CDI increases significantly in the case where antimicrobial treatment reduces the number of competing bacteria in the gut, thus leading to the increased availability of nutrients and loss of colonization resistance. The objective of this study was to determine comprehensive nutritional utilization and the chemical sensitivity profile of historic and newer C. difficile isolates and to examine the possible role of the phenotype diversity in C. difficile virulence. Methods Phenotype microarrays (PMs) were used to elucidate the complete nutritional and chemical sensitivity profile of six C. difficile isolates. Results Of the 760 nutrient sources tested, 285 compounds were utilized by at least one strain. Among the C. difficile isolates compared, R20291, a recent hypervirulent outbreak-associated strain, appears to have an expanded nutrient utilization profile when compared to all other strains. Conclusions The expanded nutritional utilization profile of some newer C. difficile strains could be one of the reasons for infections in patients who are not exposed to the hospital environment or not undergoing antibiotic treatment. This nutritional profile could be used to design tube feeding formulas that reduce the risk of CDI.

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“…Two independent human trials conducted in Bangladesh and Venezuela, respectively, have recently found that feeding children a diet enriched in cooked green bananas can significantly hasten recovery from shigellosis, a diarrheal disease caused by the bacterium Shigella (Alvarez-Acosta et al, 2009; Rabbani et al, 2009). Although the exact mechanistic basis for this effect has not been established, the observed increase in short-chain fatty acid production by the distal microbiota that occurs upon enrichment of dietary starch has been proposed to result in an intestinal environment unfavorable to Shigella .…”

Section: …And How Those End Products Influence Interspecies Interactionsmentioning

confidence: 99%

Eating For Two: How Metabolism Establishes Interspecies Interactions in the Gut

Fischbach

Sonnenburg

2011

Cell Host & Microbe

412

351

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In bacterial communities, ‘tight economic times’ are the norm. Of the many challenges bacteria face in making a living, perhaps none are more important than generating energy, maintaining redox balance, and acquiring carbon and nitrogen to synthesize primary metabolites. The ability of bacteria to meet these challenges depends heavily on the rest of their community. Indeed, the most fundamental way in which bacteria communicate is by importing the substrates for metabolism and exporting metabolic end products. As an illustration of this principle, we will travel down a carbohydrate catabolic pathway common to many species of Bacteroides, highlighting the interspecies interactions established (often inevitably) at its key steps. We also discuss the metabolic considerations in maintaining the stability of host-associated microbial communities.

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Beneficial Role of Green Plantain [Musa paradisiaca] in the Management of Persistent Diarrhea: A Prospective Randomized Trial

Abstract: Our results support the benefits of green plantain in the dietary management of persistent diarrhea in hospitalized children, in relation to diarrheal duration, weight gain and costs.

Cited by 31 publications

References 29 publications

Gut Microbiota-Produced Succinate Promotes C. difficile Infection after Antibiotic Treatment or Motility Disturbance

Gut Microbiota-Produced Succinate Promotes C. difficile Infection after Antibiotic Treatment or Motility Disturbance

Comparative nutritional and chemical phenome of Clostridium difficile isolates determined using phenotype microarrays

Eating For Two: How Metabolism Establishes Interspecies Interactions in the Gut

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