Beneficial regulation of matrixmetalloproteinases and their inhibitors, fibrillar collagens and transforming growth factor-β by Polypodium leucotomos, directly or in dermal fibroblasts, ultraviolet radiated fibroblasts, and melanoma cells

Philips, Neena; Conte, Jennifer; Chen, Yujun; Natrajan, Prashanti; Taw, May; Keller, Thomas; Givant, Joshua; Tuason, Marvin; Dulaj, Luiji; Leonardi, Donna; González, Salvador

doi:10.1007/s00403-009-0950-x

Cited by 92 publications

(121 citation statements)

References 57 publications

Supporting

Mentioning

112

Contrasting

Unclassified

Order By: Relevance

“…leucotomos extract inhibits MMP activity directly and the cellular expression of MMPs, while stimulating the expression of TIMPs in dermal fibroblasts and melanoma 2 ISRN Oxidative Medicine cells [2,3]. P. leucotomos extract inhibits the expression of MMPs in epidermal keratinocytes; however, its regulation of elastase activity directly, or cellular expression of TIMPs in epidermal keratinocytes, has not been reported [2].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Beneficial Regulation of Elastase Activity and Expression of Tissue Inhibitors of Matrixmetalloproteinases, Fibrillin, Transforming Growth Factor-β, and Heat Shock Proteins by P. leucotomos in Nonirradiated or Ultraviolet-Radiated Epidermal Keratinocytes

Philips

González

2013

ISRN Oxidative Medicine

Self Cite

View full text Add to dashboard Cite

There is loss of the structural integrity of the extracellular matrix (ECM) with intrinsic aging as well as photoaging, largely due to reactive oxygen species (ROS). The structural ECM proteins include the microfibrils that are composed of fibrillin. The structural ECM proteins are primarily degraded by the matrixmetalloproteinases (MMPs) and elastase enzymes. The MMPs are inhibited by the tissue inhibitors of MMPs (TIMPs). A primary regulator of the ECM proteins is transforming growth factor-(TGF-), and the chaperone proteins important for its formation are the heat shock proteins (HSP). P. leucotomos extract beneficially regulates of MMPs, TIMPs, and TGF-in nonirradiated or ultraviolet (UV) radiated fibroblasts and melanoma cells. The hypothesis of this research was that the antioxidant activity or chemistry of P. leucotomos extract would also directly inhibit elastase activity, stimulate the cellular expression of TIMPs, fibrillins, and TGF-, and regulate HSPs in nonirradiated and UVA or UVB radiated epidermal keratinocytes. P. leucotomos directly inhibited elastase activity, stimulated the cellular expression of TIMPs, fibrillins, and TGF-, and differentially regulated HSPs in nonirradiated and UVA or UVB radiated epidermal keratinocytes. We infer that the P. leucotomos extract strengthens the ECM and is effective in the prevention or treatment of intrinsic and photoaging of skin.

show abstract

Section: Introductionmentioning

confidence: 99%

“…The stimulation of fibrillin has been used as a marker to screen for photoaging repair agents [4][5][6]. P. leucotomos extract stimulates the expression of elastin in dermal fibroblasts and keratinocytes [3]. The regulation of fibrillin by P. leucotomos extract has not been reported and was one of the goals of this research.…”

Section: Introductionmentioning

confidence: 99%

Beneficial Regulation of Elastase Activity and Expression of Tissue Inhibitors of Matrixmetalloproteinases, Fibrillin, Transforming Growth Factor-β, and Heat Shock Proteins by P. leucotomos in Nonirradiated or Ultraviolet-Radiated Epidermal Keratinocytes

Philips

González

2013

ISRN Oxidative Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…[11][12][13][14][15] It has been widely reported that natural compounds from plants are potential sources of MMP inhibitors, which may prevent or mitigated UV-induced skin aging. [16][17][18] Stewartia koreana (Theaceae), a deciduous tree, is native to Korea and grows throughout the whole area of Korea.…”

mentioning

confidence: 99%

A Glycosidic Spinasterol from Koreana stewartia Promotes Procollagen Production and Inhibits Matrix Metalloproteinase-1 Expression in UVB-Irradiated Human Dermal Fibroblasts

Lee

et al. 2011

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

UV irradiation, particularly that of UVB (290-320 nm), causes various adverse effects to human skin, the most serious being skin cancer and premature skin aging (photoaging). [1][2][3] The functional properties of skin depend on the integrity of collagens, which are the most abundant structural proteins in dermis. 4) Type 1 collagen, which accounts for 70-90% of all collagen, is synthesized by fibroblasts as a soluble precursor, type 1 procollagen, secreted and proteolytically processed to form insoluble collagen fibers in the dermis. 5,6) The production and fibrillar organization of collagen in the skin are reduced by UV irradiation whereas gene expression of matrix metalloproteinases (MMPs) is increased. 7) Among MMPs, MMP-1 is the most responsible for the degradation of type 1 collagen in the skin. [8][9][10] Collagen degradation and inhibition of collagen production impair the structural integrity of the skin during photoaging. Therefore, control of collagen metabolism may be useful for a variety of therapeutic and cosmetic applications.Recently, a variety of herbs and plants have traditionally been used in cosmetic applications for the treatment of collagen synthesis and collagenase inhibition. [11][12][13][14][15] It has been widely reported that natural compounds from plants are potential sources of MMP inhibitors, which may prevent or mitigated UV-induced skin aging. [16][17][18] Stewartia koreana (Theaceae), a deciduous tree, is native to Korea and grows throughout the whole area of Korea. It prefers a partly shaded to full sun area, and favors a rich, moist, well-drained, and acidic loam. The leaves are dark green, elliptical, and mildly serrulate, and alternately arranged on stem. In autumn, the leaves turn a bright red to reddish purple. Usually in July, white solitary flowers bloom with 5-6 petals and yellow stamens. The flowers open wider with a more flattened look than most other species of Stewartia. The fruits ripen as an inconspicuous pentagon-shaped one in October.The bark is well exfoliated, ranging in color from soft grays and tans to orange and reddish browns. 19) We previously reported that Stewarita koreana extract induced angiogenesis and extracellular matrix (ECM) remodeling in a mouse model. It has also been reported that alcohol extracts from Stewartia koreana stimulate vasculization in vivo 20) but there is no report for the individual components of the plant. In addition, our preliminary experiments showed that the alcohol extracts were very effective in restoring wounds on punched skin of the back of mice. Therefore, this study was initiated to determine the principal components that manifest the biological activity. We isolated a number of compounds from Stewarita koreana extract. In the present study, we identified an active compound, 3-O-b-D-glucopyranosylspinasterol (spinasterol-Glc), and investigated its effect on the levels of collagen and on the expression of MMP-1 in UVB-treated fibroblast cells. We found that spinasterol-Glc inhibits collagen degradation in UVB-induced fib...

show abstract

“…Za główne wykładniki starzenia skóry uznaje się zmniejszenie syntezy kolagenu oraz zwiększenie ekspresji metaloproteinaz macierzy zewnątrzkomórkowej (ang. matrix metalloproteinases -MMP), szczególnie kolagenazy (MMP-1) [8,9]. Dlatego też terapie z zakresu kosmetologii i medycyny estetycznej zmniejszające objawy starzenia skó-ry polegają na przywróceniu niedoborów kolagenu, z jednej strony poprzez pobudzanie jego syntezy, natomiast z drugiej poprzez redukcję MMP rozkła-dających włókna kolagenowe.…”

Section: Odmładzanie Skóryunclassified

Effects of LED radiation on the skin – what is new in recent research? Part II. In skin remodeling processes and hair growth

Dana¹,

Batory²,

Erkiert‐Polguj³

et al. 2015

View full text Add to dashboard Cite

Przegląd Dermatologiczny 2015/6 564 STRESZCZENIE Światło LED (ang. light emitting diodes) znalazło szerokie zastosowanie w medycynie estetycznej i kosmetologii, głównie ze względu na moż-liwości pobudzania przebudowy skóry właściwej bez wywoływania efektu termicznego. Szczególne znaczenie ma to w planowaniu terapii przeciwstarzeniowych oraz gojeniu ran. Okazało się, że światło LED stymuluje proliferację fibroblastów, syntezę kolagenu, czynników wzrostu, wytwarzanie macierzy zewnątrzkomórkowej oraz pobudza mikrokrążenie skóry (stosowano różne długości fali światła: 590 nm, 630 nm, 633 nm, 830 nm). Ponadto w badaniach na myszach stwierdzono wpływ zielonego światła LED (518 nm) na przyspieszenie gojenia ran. Terapia ta może również przeciwdziałać bliznowaceniu. Ciekawym aspektem oddziaływania światła LED jest także pobudzanie wzrostu włosów (638 nm). ABSTRACTLight-emitting diodes (LED) have found widespread use in aesthetic medicine and cosmetology, mainly due to the possibility to stimulate the dermis without inducing a thermal effect. This is of particular importance in planning anti-aging therapies and wound healing. LED light stimulates fibroblast proliferation, collagen synthesis, growth factors, extracellular matrix production and skin microcirculation (used as different wavelengths of light: 590 nm, 630 nm, 633 nm, 830 nm). Furthermore, experiments with mice have shown the effectiveness of green waves (518 nm) in wound healing. This therapy can also prevent scarring. The impact of red waves (638 nm) is also interesting -they accelerate the rate of hair regrowth.Oddziaływanie światła LED na skórę -co nowego w badaniach z ostatnich lat? Część II: W procesach przebudowy skóry oraz wzroście włosów

show abstract

Beneficial regulation of matrixmetalloproteinases and their inhibitors, fibrillar collagens and transforming growth factor-β by Polypodium leucotomos, directly or in dermal fibroblasts, ultraviolet radiated fibroblasts, and melanoma cells

Cited by 92 publications

References 57 publications

Beneficial Regulation of Elastase Activity and Expression of Tissue Inhibitors of Matrixmetalloproteinases, Fibrillin, Transforming Growth Factor-β, and Heat Shock Proteins by P. leucotomos in Nonirradiated or Ultraviolet-Radiated Epidermal Keratinocytes

Beneficial Regulation of Elastase Activity and Expression of Tissue Inhibitors of Matrixmetalloproteinases, Fibrillin, Transforming Growth Factor-β, and Heat Shock Proteins by P. leucotomos in Nonirradiated or Ultraviolet-Radiated Epidermal Keratinocytes

A Glycosidic Spinasterol from Koreana stewartia Promotes Procollagen Production and Inhibits Matrix Metalloproteinase-1 Expression in UVB-Irradiated Human Dermal Fibroblasts

Effects of LED radiation on the skin – what is new in recent research? Part II. In skin remodeling processes and hair growth

Contact Info

Product

Resources

About