1976
DOI: 10.1016/0002-9149(76)90396-9
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Beneficial metabolic effects of methylprednisolone sodium succinate in acute myocardial ischemia

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1978
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Cited by 32 publications
(7 citation statements)
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“…This observation confirmed results reported by Masters et al, 8 who used MP (40 mg/kg). However, no significant differences were noted in the degree of depression of AP between the untreated and MPtreated groups in the pre-occlusion (untreated: 119 ± 5; MP-treated: 121 ± 3) or the post-occlusion (untreated: 112 ± 3 at 5 minutes to 104 ± 5 at 120 minutes; MP-treated: 108 ± 4 at 5 minutes to 103 ± 6 at 120 minutes) periods.…”
Section: Hemodynamic Parameterssupporting
confidence: 92%
“…This observation confirmed results reported by Masters et al, 8 who used MP (40 mg/kg). However, no significant differences were noted in the degree of depression of AP between the untreated and MPtreated groups in the pre-occlusion (untreated: 119 ± 5; MP-treated: 121 ± 3) or the post-occlusion (untreated: 112 ± 3 at 5 minutes to 104 ± 5 at 120 minutes; MP-treated: 108 ± 4 at 5 minutes to 103 ± 6 at 120 minutes) periods.…”
Section: Hemodynamic Parameterssupporting
confidence: 92%
“…The mechanism by which glucocorticoids may benefit acutely ischemic myocardium remains conjectural. 1 hey may stabilize cell membranes, prevent or delay the release of lysosomal enzymes (33,34), stabilize the phagocytic vacuoles in infiltrating inflammatory cells, thereby reducing their heterolytic activity (16), inhibit the generation of prostaglandins and thromboxanes (35), exert other antiinflammatory actions, or increase collateral blood flow to the ischemic myocardium (36).…”
Section: Methodsmentioning
confidence: 99%
“…The study by Masters et al 17 indicated the beneficial effect of methylprednisolone, 40 rag. kg-~, on carbohydrate metabolism maintaining the generation of energyproducing substrates in acute myocardial ischacmia.…”
Section: Discussionmentioning
confidence: 99%