Beneficial Function of Taurine on Bone Metabolism in Alcohol-Fed OVX Rat Model

Mi-Ja, Choi; Chang, Kyung-Ja; Lee, Jung Won; Jung, Yun-Jung

doi:10.1007/978-94-024-1079-2_84

Cited by 7 publications

(6 citation statements)

References 26 publications

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“…Also, recent metabolomics studies reported that the amino acids including glutamine [ 8 ], tryptophan [ 9 ], and cystine [ 10 ] were associated with BMD in postmenopausal women of East Asian. Of these identified BMD-related amino acids in our study, GABA [ 28 ], cysteine [ 29 ], taurine [ 30 ], and glutamic acid [ 31 ] have shown some evidence for their potential roles in bone metabolism by in vitro and/or in vivo studies.…”

Section: Discussionmentioning

confidence: 97%

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Metabolomic profiles associated with bone mineral density in US Caucasian women

Zhao

Shen

et al. 2018

Nutr Metab (Lond)

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BackgroundIndividuals’ peak bone mineral density (BMD) achieved and maintained at ages 20–40 years is the most powerful predictor of low bone mass and osteoporotic fractures later in life. The aim of this study was to identify metabolomic factors associated with peak BMD variation in US Caucasian women.MethodsA total of 136 women aged 20–40 years, including 65 subjects with low and 71 with high hip BMD, were enrolled. The serum metabolites were assessed using a liquid chromatography-mass spectrometry (LC-MS) method. The partial least-squares discriminant analysis (PLS-DA) method and logistic regression models were used, respectively, to examine the associations of metabolomic profiles and individual metabolites with BMD.ResultsThe low and high BMD groups could be differentiated by the detected serum metabolites using PLS-DA (P permutation = 0.008). A total of 14 metabolites, including seven amino acids and amino acid derivatives, five lipids (including three bile acids), and two organic acids, were significantly associated with the risk for low BMD. Most of these metabolites are novel in that they have never been linked with BMD in humans earlier. The prediction model including the newly identified metabolites significantly improved the classification of the groups with low and high BMD. The area under the receiver operating characteristic curve without and with metabolites were 0.88 (95% CI: 0.83–0.94) and 0.97 (95% CI: 0.94–0.99), respectively (P for the difference = 0.0004).ConclusionMetabolomic profiling may improve the risk prediction of osteoporosis among Caucasian women. Our findings also suggest the potential importance of the metabolism of amino acids and bile acids in bone health.

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Section: Discussionmentioning

confidence: 97%

“…Taurine supplementation has been linked with increased femur BMD in OVX rats [ 30 ]. However, another study did not observe any difference in femur bone mineral content between two groups of OVX rats fed with calcium deficient diet with or without taurine supplementation [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Metabolomic profiles associated with bone mineral density in US Caucasian women

Zhao

Shen

et al. 2018

Nutr Metab (Lond)

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“…Due to hypocalcemia in menopause, bone mineral density decreases, and the risk of fracture increases. It has been shown that taurine has a positive effect on bone mineral density and content and increases serum Ca and phosphate levels in ovariectomy-induced osteoporotic rats [ 13 ]. Taurine supplementation has been shown to significantly reduce osteocalcin levels in B12-deficient infant rats [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…It reduces bone loss by inhibiting osteoclastogenesis [ 11 , 12 ]. Animal experiments have supported that taurine supplementation reduces alveolar bone resorption [ 8 ], prevents bone loss in ovariectomized rats [ 6 , 11 , 13 ], and has anabolic effects on bone health in growing rats [ 9 , 12 ], without significant side effects or toxicity. Oral taurine tablets have been reported to reduce postoperative oxidative stress in elderly patients with hip fractures [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Investigation of taurine and aqueous garlic extract diet supplementation effect on the healing of rat osteoporotic fractures

MISIRLIOĞLU¹,

BİNGÖL²,

GENÇ³

et al. 2023

Turkish Journal of Medical Sciences

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Background/aim We have evaluated the effects of taurine and aqueous garlic extract (AGE) as a dietary supplement on osteoporotic fracture (OPF) healing in the ovariectomized rat femur fracture model. Materials and methods In this experimental animal study, twenty-four osteoporosis-remodeled female Wistar albino rats were randomly divided into 3 groups (n: 8) according to their supplemented diet; control, taurine, and AGE groups. Unilateral femur middiaphysis mini-open osteotomy was stabilized with Kirschner wires. Six weeks after osteotomy, the rats were sacrificed before the femurs were harvested and OPF healing was evaluated with biochemical, histologic, microcomputed-tomography, and scintigraphic methods. Results As an indicator of the antiosteoporotic effect, the calcium levels of the taurine group were significantly lower than the AGE and control groups in biochemical analyzes (p < 0.01). In histological studies, the new bone diameter and new bone volume values of the taurine group were significantly higher than the control group (p = 0.002 and p = 0.032, respectively), while higher trabecular-compact callus was observed in the taurine and AGE groups, respectively, compared to the control group. In morphological analyses, taurine and AGE groups had significantly higher bone volume/tissue volume, trabecular number, bone surface density, and lower trabecular separation than the control group (p < 0.05). The scintigraphic imaging showed a significant increase in osteoblastic activity of the taurine group compared to the control group (p = 0.005). Conclusion Taurine and AGE have positive anabolic effects, respectively, on the healing of OPFs, demonstrated by biochemical, histological, morphological, and scintigraphic methods.

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“…The addition of 2 % taurine in control diet increases femur BMC per weight in growing rats (Choi and Seo 2013). Taurine supplemented diets may have positive results on bone metabolism in alcohol-fed OVX rat model (Choi et al 2017). According Vol.…”

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confidence: 99%

Bone Microstructure of Mice After Prolonged Taurine Treatment

Martiniaková¹,

Sarocka

Babošová

et al. 2019

Physiol Res

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Taurine, a sulphur - containing amino acid, has been termed a functional nutrient. Its synthetic form is a common ingredient in supplements and energy drinks. There is no information concerning taurine impact on bone microstructure after prolonged supplemental use. Also, differences in bone parameters of mice following taurine exposure are unknown. In this study, a detailed microstructure of compact and trabecular bone tissues of mice subchronically exposed to taurine was determined. Animals (n=12) were segregated into three groups: E1 group – mice received 20 mg/kg b.w. of taurine per day during 8 weeks; E2 group – mice were fed by taurine at a dose of 40 mg/kg b.w. for 8 weeks and a control (C) group. Decreased density of secondary osteons, increased sizes of primary osteon's vascular canals (P<0.05) were observed in taurine – treated animals. Cortical bone thickness, trabecular thickness were decreased (P<0.05) in E1 group, and relative volume of trabecular bone was lower (P<0.05) in E2 group as compared to C group. According to our results, prolonged taurine exposure at the doses used in this study can negatively affect both compact and trabecular bone tissues microstructure.

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Beneficial Function of Taurine on Bone Metabolism in Alcohol-Fed OVX Rat Model

Cited by 7 publications

References 26 publications

Metabolomic profiles associated with bone mineral density in US Caucasian women

Metabolomic profiles associated with bone mineral density in US Caucasian women

Investigation of taurine and aqueous garlic extract diet supplementation effect on the healing of rat osteoporotic fractures

Bone Microstructure of Mice After Prolonged Taurine Treatment

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