Beneficial Effects of ε-Viniferin on Obesity and Related Health Alterations

Abstract

Viniferin is a phenolic compound belonging to the group of stilbenoids. In particular, ε-viniferin is a dimer of resveratrol, found in many plant genders, among which grapes (Vitis vinifera) are a primary source. Due to the fact that ε-viniferin is mainly present in the woody parts of plants, their use as a source of this bioactive compound is a very interesting issue in a circular economy. Both, in vitro studies carried out in pre-adipocytes and mature adipocytes and in vivo studies addressed in mice show that ε-viniferin is able to reduce fat accumulation. Moreover, it prevents the development of some obesity co-morbidities, such as type 2 diabetes, dyslipidemias, hypertension and fatty liver. ε-viniferin can be absorbed orally, but it shows a very low bioavailability. In this scenario, further research on animal models is needed to confirm the effects reported in a great number of studies; to determine which metabolites are involved, including the main one responsible for the biological effects observed and the mechanisms that justify these effects. In a further phase, human studies should be addressed in order to use ε-viniferin as a new tool for obesity management, as a nutraceutical or to be included in functional foods.

Trans-Resveratrol as a Health Beneficial Molecule: Activity, Sources, and Methods of Analysis

“…In a study conducted by Timmers and colleagues [35], the impact of a 30-day oral supplementation regimen with pure trans-Resveratrol (at a daily dose of 150 mg) on metabolic alterations in obese individuals was investigated. The findings of this research shed light on the significant scientific implications of trans-Resveratrol supplementation.…”

“…SIRT1 plays a role in regulating cellular energy production, while PGC-1α is involved Scientiae Radices, 2(3), 268-294 (2023) 280 in mitochondrial biogenesis and oxidative metabolism. These effects imply that trans-Resveratrol may have the potential to enhance the body metabolic activity and energy production, which can be crucial for individuals struggling with obesity [35].…”

Aroma Profile of Grapevine Chips after Roasting: A Comparative Study of Sorbara and Spergola Cultivars for More Sustainable Oenological Production

“…Phytoalexins are essential molecules that play critical roles in protecting plants against pathogenic microorganisms. Among these bioactive compounds, trans-resveratrol and trans-ε-viniferin have been extensively studied for their wide-ranging health benefits in humans, including anticancer, cardioprotective, and antioxidant effects [9,10]. Additionally, they exhibit antifungal properties and serve as natural preservatives in wine production [11].…”

Characterization of Some Stilbenoids Extracted from Two Cultivars of Lambrusco—Vitis vinifera Species: An Opportunity to Valorize Pruning Canes for a More Sustainable Viticulture

“…In particular, trans -resveratrol has gained worldwide attention for its beneficial effects on human health. In addition, its oxidative polymerization produces oligomers, including trans -ε-viniferin, which have many beneficial biological properties [ 14 , 15 , 16 ], including antimicrobial, anticancer, hepatoprotective, and antioxidant properties [ 17 , 18 ]. These compounds are found in grapes, berries, and nuts but are also readily contained in viticulture by-products.…”