2002
DOI: 10.1016/s0304-3940(02)00056-3
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Beneficial effects of α-lipoic acid plus vitamin E on neurological deficit, reactive gliosis and neuronal remodeling in the penumbra of the ischemic rat brain

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Cited by 62 publications
(39 citation statements)
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“…The research showed that ALA-VE mixtures reduce glial scar and increase the expression of remodelling proteins when both antioxidants were administrated pre-and post-ischemia. In addition, the authors reported important functional recovery as a consequence of the prophylactic administration of these antioxidants [42]. Additional findings indicate that a prophylactic treatment with an ALA-VE mixture can reduce infarct volume and lipid peroxidation after cerebral ischemia [43].…”
Section: Synergism Between Lipoate and Tocopherolmentioning
confidence: 80%
“…The research showed that ALA-VE mixtures reduce glial scar and increase the expression of remodelling proteins when both antioxidants were administrated pre-and post-ischemia. In addition, the authors reported important functional recovery as a consequence of the prophylactic administration of these antioxidants [42]. Additional findings indicate that a prophylactic treatment with an ALA-VE mixture can reduce infarct volume and lipid peroxidation after cerebral ischemia [43].…”
Section: Synergism Between Lipoate and Tocopherolmentioning
confidence: 80%
“…Co-administration of ALA with other medications (vitamin E, apocynin, acetyl-l-carnitine, resveratrol, etc.) enhances its neuroprotective effects in a rat model of I/RI [23,24,33]. Moreover, ischaemic preconditioning and ALA preconditioning provide stronger protective effects against hepatic I/RI-induced toxicity in rats [30].…”
Section: Discussionmentioning
confidence: 98%
“…There exists support in the literature for the potential neurotrophic role of vitamin E in ischemic animal models. Gonzalez-Perez et al 48 have shown a beneficial effect of vitamin E on neural remodeling in an ischemic rat model. Additionally, vitamin E has been shown to Erectile function in a diabetic animal model L De Young et al reduce oxidative stress in congestive heart failure, the mechanism is not yet known, but may have in our work contributed to the improved intracorporal pressure rises.…”
Section: Vitamin E Vit E + Sildenafilmentioning
confidence: 99%