Beneficial effects of Zingiber officinale on goldthioglucose induced obesity

Goyal, Ramesh K.; Kadnur, Sanjay V.

doi:10.1016/j.fitote.2006.01.005

Cited by 67 publications

(56 citation statements)

References 13 publications

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“…However, no change in plasma lipids was observed in normal rats treated with a whole ginger powder [22,23] or fresh juice [24] of Zingiber officinale. The anti-obesity actions of ginger extracts were also noticed recently in chemical [25] and in high-fat diet (HFD)-induced obese mice [26]. In our recent investigation, we have shown a protective effect of Zingiber officinale extract against derangement of circulating lipids in HFD-fed rats [27].…”

supporting

confidence: 57%

Regulation of Low‐Density Lipoprotein Receptor and 3‐Hydroxy‐3‐Methylglutaryl Coenzyme A Reductase Expression by Zingiber officinale in the Liver of High‐Fat Diet‐Fed Rats

Nammi

Kim

Gavande

et al. 2010

Basic Clin Pharma Tox

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Zingiber officinale has been used to control lipid disorders and reported to possess remarkable cholesterol-lowering activity in experimental hyperlipidaemia. In the present study, the effect of a characterized and standardized extract of Zingiber officinale on the hepatic lipid levels as well as on the hepatic mRNA and protein expression of low-density lipoprotein (LDL) receptor and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase was investigated in a high-fat diet-fed rat model. Rats were treated with an ethanol extract of Zingiber officinale (400 mg ⁄ kg) extract along with a high-fat diet for 6 weeks. The extract of Zingiber officinale significantly decreased hepatic triglyceride and tended to decrease hepatic cholesterol levels when administered over 6 weeks to the rats fed a high-fat diet. We found that in parallel, the extract up-regulated both LDL receptor mRNA and protein level and down-regulated HMG-CoA reductase protein expression in the liver of these rats. The metabolic control of body lipid homeostasis is in part due to enhanced cholesterol biosynthesis and reduced expression of LDL receptor sites following long-term consumption of high-fat diets. The present results show restoration of transcriptional and post-transcriptional changes in low-density lipoprotein and HMG CoA reductase by Zingiber officinale administration with a high-fat diet and provide a rational explanation for the effect of ginger in the treatment of hyperlipidaemia.Although cholesterol is an essential component of mammalian cell membranes, excess cellular and circulating cholesterol is detrimental and contributes to several life-threatening diseases, including atherosclerotic and coronary artery cardiovascular disease [1,2]. Cellular cholesterol homeostasis is maintained primarily through regulation of the low-density lipoprotein (LDL) receptor and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which respectively affect the uptake and endogenous synthesis of cholesterol in the liver [3][4][5]. A large number of studies have elucidated the role of these regulatory mechanisms in vitro, in experimental animals and in humans treated with experimental diets or drugs [6][7][8]. Recent studies have also shown a regulatory effect of various phyto-ingredients on potential targets controlling in vivo cholesterol homeostasis in animal models treated with atherogenic diets [9][10][11].Zingiber officinale Roscoe (Family: Zingiberaceae) commonly known as 'ginger', is a well-known food spice which has also been used traditionally in a wide variety of ailments [12,13]. The major chemical constituents of ginger rhizome are essential volatile oils and non-volatile pungent compounds [14,15]. The volatile oil components consist mainly of various terpenoids. The non-volatile compounds include the gingerols, shogaols, paradols and zingerone. Among them, the gingerols and shogaols were identified as the major bioactive constituents of ginger, found respectively in fresh and dried ginger [16].In laboratory experiments, e...

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supporting

confidence: 57%

Regulation of Low‐Density Lipoprotein Receptor and 3‐Hydroxy‐3‐Methylglutaryl Coenzyme A Reductase Expression by Zingiber officinale in the Liver of High‐Fat Diet‐Fed Rats

Nammi

Kim

Gavande

et al. 2010

Basic Clin Pharma Tox

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“…This result is in agreement with those reported by Tejasari [15] (10.2%), Tewtrakul and Subhadhirasakul [22] (11.4% and 10.4%), and Ahui et al [26] (11%). However, it is higher than those obtained by Mascolo et al [6] (2.8%), Alfaro et al [27] (3.6, 3.2, and 0.27%), and Goyal and Kadnur [28] (4.6 and 4.3%).…”

Section: Results and Discussion Extraction Yieldscontrasting

confidence: 58%

Antioxidant Activity of the Essential Oil and Oleoresin ofZingiber OfficinaleRoscoe as Affected by Chemical Environment

Bellik

Benabdesselam

Ayad

et al. 2013

International Journal of Food Properties

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Three different biochemical test systems were chosen based on their solubility to study the antioxidant activity of ginger extracts. Reducing power and DPPH . scavenging activity tests were considered to produce hydrophilic environments and the H 2 O 2 test was considered as creating a lipophilic environment. The average yields were 10.23 ± 1.02% and 0.48 ± 0.19% for oleoresin and essential oil, respectively. The content of total phenols was 67.6 ± 1.08 mg GAE/g of dry extract. In terms of EC 50 , in hydrophilic environment standards, it showed the highest effects compared to ginger extracts, with oleoresin presenting more activity than essential oil. In contrast, except for quercetin, essential oil showed the best scavenging activity in inhibiting H 2 O 2 compared to all other antioxidants. The present work demonstrated that, when using reducing power, DPPH· free radical scavenging and H 2 O 2 scavenging assays, the same ginger extracts exhibit different antioxidant activities, which were affected not only by the extract itself but also by the chemical environment (hydrophilic/lipophilic).

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“…Recently, Heimes et al (2009) supported the hypoglycemic potential of ginger. Islam and Choi (2008) suggested that ginger has insulin optropic properties that are mainly attributed to its glucose-lowering potential (Sekiya et al, 2004;Goyal and Kadnur, 2006;Heimes et al, 2009). A later study showed that-shogaol or -gingerol significantly inhibited TNF-α-mediated downregulation of adiponectin expression in 3T3-L1 adipocytes (Isa et al, 2008).…”

Section: Health Effects: the Scientific Evidencementioning

confidence: 99%

“…The antioxidant activity of ginger extract is depend on the concentration of 6-gingerol in the extract. In a study, it was investigated the concentration 6-gingerol is highly related to the antihyperlipidemic effects of ginger extract in fructose induced hypolipidemic rats (Goyal and Kadnur, 2006). Kadnur and Goyal, (2005) explored the effectiveness of ginger extract by orally administration at the dose of 100, 200, 400 mg/kg for 60 days in hyperinsulinemic and hyperglycemic rats.…”

Section: Introductionmentioning

confidence: 99%

An Overview: Ginger, a Tremendous Herb

Shoaib¹,

Shehzad²,

Butt³

et al. 2016

(JGIASS

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Novel nutritional approaches are becoming a major modifiable determinant of chronic diseases. Scientific evidences have supported dietary intervention as an effective tool for healthy life style. In this context, functional foods and nutraceuticals may provide a mean to reduce the increasing burden on health care system by a disease preventive mechanism. Ginger has many biologically active components like polyphenols and flavonoids contain health related properties including anticancer, antiviral and antihypertensive. This review will cover all the aspects of bioactive components of ginger and their healthbenefits especially hypocholesterolemic and hypoglycemic role.

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Beneficial effects of Zingiber officinale on goldthioglucose induced obesity

Cited by 67 publications

References 13 publications

Regulation of Low‐Density Lipoprotein Receptor and 3‐Hydroxy‐3‐Methylglutaryl Coenzyme A Reductase Expression by Zingiber officinale in the Liver of High‐Fat Diet‐Fed Rats

Regulation of Low‐Density Lipoprotein Receptor and 3‐Hydroxy‐3‐Methylglutaryl Coenzyme A Reductase Expression by Zingiber officinale in the Liver of High‐Fat Diet‐Fed Rats

Antioxidant Activity of the Essential Oil and Oleoresin ofZingiber OfficinaleRoscoe as Affected by Chemical Environment

An Overview: Ginger, a Tremendous Herb

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