Beneficial effects of voluntary over forced exercise on skeletal muscle structure and myokines’ expression

Eldomiaty, Magda A.; Elayat, Ahmed A.; Ali, Soad Shaker; Algaidi, Sami A.; Elnaggar, Mohamed Nabil

doi:10.5603/fm.a2019.0131

Cited by 8 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, the effects of a resistance training program has been evaluated in adult rats, where increased myogenin, MyoD, and IGF-I mRNA levels with enhanced muscle size was found ( Aguiar et al, 2013 ). However, forced exercise training-induced negative stress could lead to muscle atrophy ( Eldomiaty et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Voluntary Physical Activity in an Enriched Environment and Combined Exercise Training on the Satellite Cell Pool in Developing Rats

et al. 2022

View full text Add to dashboard Cite

Aim: Postnatal skeletal muscle growth is strongly associated with a satellite cell pool. Early adolescence might be a crucial period when different exercise training interventions have specific consequence on satellite cells. Pax7 and MyoD have been suggested as the leading indicators of satellite cell activation.Methods: In this study, pre-adolescent male rats (n = 18) were either subjected to an enriched environment that facilitated physical activities or combined training or control for three weeks. The flexor hallucis longus muscle was removed for biochemical and histochemical analysis.Results: Findings demonstrated that exercise trained rats displayed high levels of serum IGF-1 (p <0.05). There was an increase in Pax7 (p <0.05) and MyoD (p <0.001) mRNA expression. A significant increase in the mean fiber area (p <0.01), satellite cell (p <0.001), and myonuclear numbers (p <0.01) were also observed in both intervention groups. Importantly, enriched rats showed lower corticosterone levels (p <0.05) compared to training ones. Regarding performance, trained and enriched rats had significant improvement in forelimb grip strength (p <0.01) and load-carrying capacity (p <0.05).Conclusion: Type of physical exercise is an essential part in changing satellite cells pool. Different and frequent physical activities in an enriched environment can be effective for muscle development.

show abstract

Section: Introductionmentioning

confidence: 99%

The Effect of Voluntary Physical Activity in an Enriched Environment and Combined Exercise Training on the Satellite Cell Pool in Developing Rats

et al. 2022

View full text Add to dashboard Cite

show abstract

“…However, unsuitable forced training may cause systemic stress and muscle strain. [53][54][55] On the other hand, voluntary exercise such as wheel running in animal studies induces less corticosterone stress response than forced training 56 and may lead to a better emotional experience and more sustainable improvement. 57,58 Voluntary exercise is uncontrollable in clinic application and leads to less neuroprotective effects compared with forced treadmill training.…”

Section: Discussionmentioning

confidence: 99%

Agrin Involvement in Synaptogenesis Induced by Exercise in a Rat Model of Experimental Stroke

Zhang

Yang

et al. 2020

Neurorehabil Neural Repair

View full text Add to dashboard Cite

Background Agrin is a proteoglycan that aggregates nicotinic acetylcholine receptors (AChRs) on neuromuscular junctions and takes part in synaptogenesis in the development of the central nervous system. However, its effects on neural repair and synaptogenesis after stroke are still unclear. Objective This study aimed to investigate the effects of agrin on neural repair and synaptogenesis after stroke and the effects of exercise on this process in vivo and in vitro. Methods Exercise with gradually increased intensity was initiated at 1 day after middle cerebral artery occlusion (MCAO) for a maximum of 14 days. Neurological deficit scores and foot fault tests were used to assess the behavioral recovery. Western blotting, immunofluorescence, and electron microscopic images were used to detect the expression of agrin, synaptogenesis-related proteins, and synaptic density in vivo. In vitro, the ischemic neuron model was established via oxygen-glucose deprivation (OGD). The lentivirus overexpressed agrin and CREB inhibitor were used to investigate the mechanism by which agrin promoted synaptogenesis. Results Exercise promoted behavioral recovery and this beneficial role was linked to the upregulated expression of agrin and increased synaptic density. Overexpressed agrin promoted synaptogenesis in OGD neuron, CREB inhibitor downregulated the expression of agrin and hampered synaptogenesis in cultured neurons. Conclusions These results indicated that exercise poststroke improved the recovery of behavioral function after stroke. Synaptogenesis was an important and beneficial factor, and agrin played a critical role in this process and could be a potential therapeutic target for the treatment of stroke and other nervous system diseases.

show abstract

“…Human and animal studies have shown that physical activity can stimulate synthesis and the release of endogenous neurotrophins. The number of publications concerning the beneficial effect of various types of aerobic exercise and training on enhancing BDNF levels in the brain and peripheral blood both in animal models (Afzalpour et al, 2015;Eldomiaty et al, 2017;TaheriChadorneshin et al, 2017;Algaidi et al, 2019) and humans (Currie et al, 2009a;Damirchi et al, 2014;Huang et al, 2014;Dinoff et al, 2017) is constantly increasing. Training-induced increase in BDNF levels improves cognitive function (Best et al, 2015;Hákansson et al, 2017;Nilsson et al, 2020) and mood (Rethorst et al, 2009) in healthy people and people with cognitive impairment (Nascimento et al, 2015) and depression (Schuch et al, 2016;Kering et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Nordic Walking With Poles With an Integrated Resistance Shock Absorber on Cognitive Abilities and Cardiopulmonary Efficiency in Postmenopausal Women

Domaszewska¹,

Koper²,

Wochna³

et al. 2020

Front. Aging Neurosci.

View full text Add to dashboard Cite

Late adulthood is associated with atrophy of brain areas, which contribute to cognitive deterioration and increase the risk of depression. On the other hand, aerobic exercise can improve learning and memory function, ameliorate mood, and prevent neurodegenerative changes. This study demonstrates the effect of Nordic walking (NW) and NW with poles with an integrated resistance shock absorber (NW with RSA) on aerobic capacity and body composition in postmenopausal women. It also measures the brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) serum levels and determines correlations with cognitive functions and depression symptoms. These relationships with the use of NW with RSA as a new form of exercise have not been described thus far. In this study, 31 women (NW-16, NW with RSA-15) participated in eight weeks of training. The findings showed that only NW with RSA training caused a significant decrease in body mass and body mass index (p < 0.05). There were no significant changes in GDNF levels between groups studied. Regarding BDNF, a significant decrease (p < 0.05) in the NW group and an increase (not statistically significant) in the NW with RSA group was found. A comparative analysis of cognitive and depression outcomes and changes in BDNF and GDNF concentration showed no significant differences in the efficacy of either form of training. Training loads resulted in a significant increase in VO 2 max in both the NW (p < 0.01) and NW with RSA (p < 0.05) groups. This indicates an improvement in cardiopulmonary efficiency of the examined women.

show abstract

Beneficial effects of voluntary over forced exercise on skeletal muscle structure and myokines’ expression

Cited by 8 publications

References 0 publications

The Effect of Voluntary Physical Activity in an Enriched Environment and Combined Exercise Training on the Satellite Cell Pool in Developing Rats

The Effect of Voluntary Physical Activity in an Enriched Environment and Combined Exercise Training on the Satellite Cell Pool in Developing Rats

Agrin Involvement in Synaptogenesis Induced by Exercise in a Rat Model of Experimental Stroke

The Effects of Nordic Walking With Poles With an Integrated Resistance Shock Absorber on Cognitive Abilities and Cardiopulmonary Efficiency in Postmenopausal Women

Contact Info

Product

Resources

About