Beneficial Effects of Vitamin E Treatment in Acute Myocardial Infarction

Sethi, Rajat; Takeda, Nobuakira; Nagano, Makoto; Dhalla, Naranjan S.

doi:10.1177/107424840000500107

Cited by 56 publications

(45 citation statements)

References 44 publications

(52 reference statements)

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“…reports are also consistent with those of other investigators compared to the control group; the arrhythmic changes showing a depression in b-adrenergic receptor density and were also attenuated significantly [94]. In addition, vitamin attenuated in adenylyl cyclase response to isoproterenol E supplement prevented the depression of left ventricular due to ischemia-reperfusion [95].…”

Section: Catalase and Superoxide Dismutase In Ischemia-supporting

confidence: 81%

“…The pattern of changes in b-adrenoreceptor linked signal content and conjugated diene formation in the infarcted rat transduction following ischemia was different from that heart [94]. These results indicate that the beneficial effects observed due to ischemia-reperfusion and the changes due of vitamin E in the acute ischemic syndromes may be to ischemia were also not prevented by oxyradical scavenoccurring through the reduction of oxidative stress.…”

Section: Catalase and Superoxide Dismutase In Ischemia-mentioning

confidence: 53%

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Status of myocardial antioxidants in ischemia–reperfusion injury

Dhalla

Elmoselhi

Hata

et al. 2000

Cardiovascular Research

695

444

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Background: Myocardial ischemia-reperfusion represents a clinically relevant problem associated with thrombolysis, angioplasty and coronary bypass surgery. Injury of myocardium due to ischemia-reperfusion includes cardiac contractile dysfunction, arrhythmias as well as irreversible myocyte damage. These changes are considered to be the consequence of imbalance between the formation of oxidants and the availability of endogenous antioxidants in the heart. Observations: An increase in the formation of reactive oxygen species during ischemia-reperfusion and the adverse effects of oxyradicals on myocardium have now been well established by both direct and indirect measurements. Although several experimental studies as well as clinical trials have demonstrated the cardioprotective effects of antioxidants, some studies have failed to substantiate the results. Nonetheless, it is becoming evident that some of the endogenous antioxidants such as glutathione peroxidase, superoxide dismutase, and catalase act as a primary defense mechanism whereas the others including vitamin E may play a secondary role for attenuating the ischemia-reperfusion injury. The importance of various endogenous antioxidants in suppressing oxidative stress is evident from the depression in their activities and the inhibition of cardiac alterations which they produce during ischemia-reperfusion injury. The effects of an antioxidant thiol containing compound, N-acetylcysteine, and ischemic preconditioning were shown to be similar in preventing changes in the ischemic-reperfused hearts. Conclusions: The available evidence support the role of oxidative stress in ischemia-reperfusion injury and emphasize the importance of antioxidant mechanisms in cardioprotection.

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Section: Catalase and Superoxide Dismutase In Ischemia-supporting

confidence: 81%

Section: Catalase and Superoxide Dismutase In Ischemia-mentioning

confidence: 53%

Status of myocardial antioxidants in ischemia–reperfusion injury

Dhalla

Elmoselhi

Hata

et al. 2000

Cardiovascular Research

695

444

View full text Add to dashboard Cite

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“…In contrast, using a model of permanent occlusion of the middle cerebral artery (MCA) in rats, van der Worp et al [8] found that deprivation of dietary VE is associated with larger cerebral infarcts. Similar VE beneficial effects were reported in acute myocardial infarction [26]. Thus, the data are inconsistent and, unfortunately, these studies did not explore the possibility of combining VE with other antioxidants that regenerate and increase alpha-tocopherol tissue concentrations, such as ALA or vitamin C (Fig.…”

Section: Lipoate and Tocopherol In Oxidative Processesmentioning

confidence: 91%

Therapeutic perspectives on the combination of α-lipoic acid and vitamin E

González-Pérez

González-Castañeda

2006

Nutrition Research

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Alpha-lipoic acid and vitamin E have synergistic effects, as determined in models of oxidant radical lesions. This review summarizes recent findings showing that the combination of alpha-lipoic acid plus vitamin E has beneficial effects in reducing oxidative damage in ischemic or other oxidationrelated pathological events. Both antioxidants are common in the normal human diet and side effects are very rare. Therefore, alpha-lipoic acid and vitamin E can counteract oxidative processes and could have an important role in clinical medicine.

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“…treatment with vitamin E (12). Rats with chronic heart hypertrophy, pretreated with vitamin E, showed a reduction in the rate of mortality, decreased content of MDA, and improved myocardial function (51), with a reduced incidence of pathological dysrhythmias (32,51). Low concentrations of ROS or exposure for a transient period may stimulate the signal transduction mechanisms both for myocyte function and gene expression.…”

Section: Discussionmentioning

confidence: 99%

High levels of myocardial antioxidant defense in aging nondiabetic normotensive Zucker obese rats

Conti

Renaud²,

Poirier³

et al. 2004

American Journal of Physiology-Regulatory, Integrative and Comp

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Chronic renal failure often induces left ventricular hypertrophy. We assessed whether the heart is affected in the Zucker obese rat, a model of chronic renal failure associated with obesity, glucose intolerance, and insulin resistance without hypertension or hyperglycemia. After systemic blood pressure measurement, the heart, the aorta, and the kidneys were removed from anesthetized 9-and 13-mo-old Zucker obese and lean control male rats (n ϭ 33, n ϭ 24, n ϭ 25, and n ϭ 21, respectively). Determination of left ventricular geometry, quantification of myocardium collagen density, and measurement of heart antioxidant enzyme activity were made, as well as aorta and kidney parameters. Mean blood pressure remained at a normal range whatever the age and group considered. Whereas kidney structure and function were severely impaired, no sign of myocardial infarction or inflammatory process was noticed. A moderate left ventricular hypertrophy was observed in 13-mo-old obese rats. While heart malondialdehyde was stable with age and among groups, antioxidant enzyme activity was higher in obese rats. In conclusion, in the absence of hypertensive or hyperglycemic disorders, the heart seems to display a sufficient line of defense against oxidative stress during the development of cardiac hypertrophy. left ventricular hypertrophy; renal failure; oxidative stress; Zucker rats; hyperlipidemia ZUCKER OBESE RATS develop, at 3 mo and onward, severe structural alterations of the kidneys and renal impairment, leading to renal failure in 9-mo-old animals (31,36,37,44,48,61). We have recently shown that these alterations are initiated in the absence of hypertension, diabetes, and inflammatory cell infiltration (37) but might derive from an oxidative stress in kidney tissue (48,49). Oxidative stress is associated with an increase in the production of reactive oxygen species (ROS), such as superoxide anion (O 2 Ϫ ⅐) and hydrogen peroxide (H 2 O 2 ), two molecules playing a key role in the generation of toxic ROS during mitochondrial respiration. Cells contain both enzymatic and nonenzymatic antioxidants that form the first line of defense against ROS (59). Briefly, superoxide dismutase (SOD) isoforms present in the cytosol (Cu/Zn-SOD) and mitochondria (Mn-SOD), convert O 2 Ϫ ⅐ to H 2 O 2 , which is detoxified to H 2 O by glutathione peroxidase (GPx) and catalase. The activity of GPx requires a supply of reduced glutathione, which is the main intracellular antioxidant. Left ventricular hypertrophy (LVH) is an independent predictor of cardiovascular morbidity and mortality (30,40). Chronic renal failure induces LVH in ϳ40% of the patients, a figure that rises up to 75% by the onset of end-stage renal disease (4, 27). Mild-to-moderate obesity, another predictor of coronary heart disease, congestive heart failure, stroke, and cardiovascular death (54), are associated with increased LVH (2,7,8,23,35,41), even in absence of hypertension or other confounding factors (3).Due to these relationships between renal failure, obesity, and LVH, we might...

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Beneficial Effects of Vitamin E Treatment in Acute Myocardial Infarction

Abstract: These results indicate that Vit E may exert beneficial effects on the heart by reducing oxidative stress in acute myocardial infarction.

Cited by 56 publications

References 44 publications

Status of myocardial antioxidants in ischemia–reperfusion injury

Status of myocardial antioxidants in ischemia–reperfusion injury

Therapeutic perspectives on the combination of α-lipoic acid and vitamin E

High levels of myocardial antioxidant defense in aging nondiabetic normotensive Zucker obese rats

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