Beneficial Effects of Vitamin C and Vitamin E Administration in Severe Head Injury

Razmkon, Ali; Sadidi, Ahmad; Sherafat-Kazemzadeh, Ehsan; Mehrafshan, Ali; Bakhtazad, Atefeh

doi:10.1227/01.neu.0000387003.89378.eb

Cited by 2 publications

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“…[177] Importantly, no increase in adverse events was detected. This study also identified that high dose vitamin C administration following injury stabilized or reduced peri-lesional edema and infarction in the majority of patients receiving post-injury treatment.…”

Section: Vitamin E and Cmentioning

confidence: 99%

“…Preclinical and more recently clinical studies have begun to support the use of vitamins E and C in reducing neuropathology and cognitive deficits following brain trauma. [ 51 87 177 240 ] Of the numerous vitamins commercially available, vitamin E has been at the forefront of many studies investigating the potential neuroprotective benefits of vitamin supplementation. Vitamin E is a collective term for eight naturally occurring compounds, four tocopherols (alpha-, beta-, gamma-, and delta-) and four tocotrienols (alpha-, beta-, gamma-, and delta-).…”

Section: Vitamin E and Cmentioning

confidence: 99%

“…In contrast, emerging evidence has suggested that daily intravenous administration of vitamin E following TBI significantly decreases mortality and improves patient outcomes when assessed at discharge and at two and six month follow-up time points. [ 177 ] Importantly, no increase in adverse events was detected. This study also identified that high dose vitamin C administration following injury stabilized or reduced peri-lesional edema and infarction in the majority of patients receiving post-injury treatment.…”

Section: Vitamin E and Cmentioning

confidence: 99%

“…This study also identified that high dose vitamin C administration following injury stabilized or reduced peri-lesional edema and infarction in the majority of patients receiving post-injury treatment. [ 177 ] Like vitamin E, vitamin C, also known as ascorbic acid, is a potent anti-oxidant present in high concentrations in the CNS. Given these similarities in action, it has been speculated that combined vitamin C and E therapy may potentiate CNS anti-oxidation and act synergistically with regards to neuroprotection.…”

Section: Vitamin E and Cmentioning

confidence: 99%

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Stuck at the bench: Potential natural neuroprotective compounds for concussion

2011

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Background:While numerous laboratory studies have searched for neuroprotective treatment approaches to traumatic brain injury, no therapies have successfully translated from the bench to the bedside. Concussion is a unique form of brain injury, in that the current mainstay of treatment focuses on both physical and cognitive rest. Treatments for concussion are lacking. The concept of neuro-prophylactic compounds or supplements is also an intriguing one, especially as we are learning more about the relationship of numerous sub-concussive blows and/or repetitive concussive impacts and the development of chronic neurodegenerative disease. The use of dietary supplements and herbal remedies has become more common place.Methods:A literature search was conducted with the objective of identifying and reviewing the pre-clinical and clinical studies investigating the neuroprotective properties of a few of the more widely known compounds and supplements.Results:There are an abundance of pre-clinical studies demonstrating the neuroprotective properties of a variety of these compounds and we review some of those here. While there are an increasing number of well-designed studies investigating the therapeutic potential of these nutraceutical preparations, the clinical evidence is still fairly thin.Conclusion:There are encouraging results from laboratory studies demonstrating the multi-mechanistic neuroprotective properties of many naturally occurring compounds. Similarly, there are some intriguing clinical observational studies that potentially suggest both acute and chronic neuroprotective effects. Thus, there is a need for future trials exploring the potential therapeutic benefits of these compounds in the treatment of traumatic brain injury, particularly concussion.

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Section: Vitamin E and Cmentioning

confidence: 99%

Section: Vitamin E and Cmentioning

confidence: 99%

Section: Vitamin E and Cmentioning

confidence: 99%

Section: Vitamin E and Cmentioning

confidence: 99%

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Stuck at the bench: Potential natural neuroprotective compounds for concussion

2011

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Harm of IV High-Dose Vitamin C Therapy in Adult Patients: A Scoping Review

Yanase

Fujii

Naorungroj

et al. 2020

Critical Care Medicine

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Objectives: The potential harm associated with the use of IV vitamin C has not been systematically assessed. We aimed to review the available evidence on harm related to such treatment. Data Sources: We searched MEDLINE, EMBASE, Cochrane Library, National Institute of Health Clinical Trials Register, and World Health Organization International Clinical Trials Registry Platform. Study Selection: We included studies in adult population that reported harm related to IV high-dose vitamin C which we defined as greater than or equal to 6 g/d, greater than or equal to 75 mg/kg/d, or greater than or equal to 3 g/m2/d. Data Extraction: Two independent investigators screened records and extracted data. Data Synthesis: We identified 8,149 reports, of which 650 full text were assessed for eligibility, leaving 74 eligible studies. In these studies, 2,801 participants received high-dose vitamin C at a median (interquartile range) dose of 22.5 g/d (8.25–63.75 g/d), 455 mg/kg/d (260–925 mg/kg/d), or 70 g/m2/d (50–90 g/m2/d); and 932 or more adverse events were reported. Among nine double-blind randomized controlled trials (2,310 patients), adverse events were reported in three studies with an event rate per patient for high-dose vitamin C identical to placebo group in one study (0.1 [1/10] vs 0.1 [1/10]), numerically lower in one study (0.80 [672/839] vs 0.82 [709/869]), and numerically higher in one study (0.33 [24/73] vs 0.23 [17/74]). Six double-blind randomized controlled trials reported no adverse event in either group. Five cases of oxalate nephropathy, five cases of hypernatremia, three cases of hemolysis in glucose-6-phosphate dehydrogenase deficiency patients, two cases of glucometer error, and one case of kidney stones were also reported overall. Conclusions: There is no consistent evidence that IV high-dose vitamin C therapy is more harmful than placebo in double-blind randomized controlled trials. However, reports of oxalate nephropathy, hypernatremia, glucometer error, and hemolysis in glucose-6-phosphate dehydrogenase deficiency patients warrant specific monitoring.

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Beneficial Effects of Vitamin C and Vitamin E Administration in Severe Head Injury

Cited by 2 publications

References 0 publications

Stuck at the bench: Potential natural neuroprotective compounds for concussion

Stuck at the bench: Potential natural neuroprotective compounds for concussion

Harm of IV High-Dose Vitamin C Therapy in Adult Patients: A Scoping Review

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