Beneficial Effects of Traditional Chinese Medicine in the Treatment of Premature Ovarian Failure

Li, Ming; Xiao, Yali; Wei, Le; Liu, Qi; Liu, Pin-Yue; Yao, Jian-Feng

doi:10.1155/2022/5413504

Cited by 12 publications

(3 citation statements)

References 66 publications

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“…Traditional Chinese medical treatments for kidney can reduce the side effects of chemotherapeutic drugs, and the selection of drugs that promote adequate blood circulation in patients is done mainly to improve the function of the ovaries and promote the correct functioning of the uterus ( 38 ). Other Chinese remedies include deer fetal ointment to relieve the symptoms of maladaptation and to regulate the endocrine system.…”

Section: Drug Protection Of Ovarian Functionmentioning

confidence: 99%

Research progress on the premature ovarian failure caused by cisplatin therapy

Li,

Qi,

et al. 2023

Front. Oncol.

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Cisplatin is a common anticancer drug able to kill tumor cells, but it causes adverse reactions in the kidney, digestive tract, and other systems. The antitumor effects of cisplatin are mainly due to its ability to bind to the DNA in tumor cells to prevent replication, thereby reducing RNA and protein syntheses, leading to cell damage and death. Cisplatin has a wide range of applications; it can be used to treat cervical, thyroid, ovarian, and other cancers. Cisplatin has a beneficial therapeutic effect, but its therapeutic selectivity is poor. In addition to eliminating diseased target cells, cisplatin can damage normal cells; in women of reproductive age being treated for cancer, cisplatin can lead to ovarian function impairment, premature ovarian failure (POF), and/or infertility. Therefore, reducing the adverse effects of cisplatin on ovarian function is an important topic in clinical research. In this paper, we explore the research progress on the POF caused by cisplatin treatment.

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Section: Drug Protection Of Ovarian Functionmentioning

confidence: 99%

Research progress on the premature ovarian failure caused by cisplatin therapy

Li,

Qi,

et al. 2023

Front. Oncol.

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“…Bazhen decoction is the combined prescription of Sijunzi and Siwu decoction, and is famous for enhancing both Qi and Xue, and balancing Yin and Yang. Thus, it is the one of the extensively used prescription for the intervention of sub-health status, and the prevention of aging-related degenerative diseases [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

The Transcriptome Induced by Bazhen Decoction and its Function in G-quadruplex Resolving and Telomere Maintenance in Progeroid Cells

Tian

Yang

et al. 2023

Preprint

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Background and Purpose: The Bazhen decoction is one of the most extensively used Traditional Chinese medicine (TCM) prescriptions for anti-aging. However, due to the complicity of the components, the pharmacological mechanism of Bazhen decoction is still limited. Experimental approach: We applied RNA sequencing and transcriptome analysis to get the full view of the signaling pathways regulated by Bazhen decoction in the wild type cell background. By using the progeroid cells derived from Werner syndrome mice, we applied Western blot, Immunofluorescence, flow cytometry and telomere FISH to verify the transcriptome data. Key Results: The transcriptome profile revealed that Bazhen decoction might systematically regulate multiple anti-aging pathways, including stem cell regulation, protein homeostasis, cardiovascular function, neuronal function, anti-inflammation, anti-DNA damage induced stress, DNA helicase activity and telomere lengthening. We found that multiple DNA helicases and telomere regulating proteins were up-regulated by Bazhen decoction, which promoted the resolving of G-quadruplex (G4) structure, and facilitated DNA replication and telomere elongation. These improvements also endowed the cellular resistance to DNA damages induced by replication stress. Together these data suggest that Bazhen decoction facilitate G4 resolving and telomere maintenance, which might contribute to the longevity sustaining properties revealed by transcriptome profile. Conclusions & Implications: Our data revealed a new strategy for recovering the pharmacological signature pathways for TCM, which could help the clinical precision medicine of TCM. By applying transcriptome in TCM-treated normal cell, we tried out a systematic analysis for dissecting the molecular mechanism of complicated TCM prescription in the normal genetic background.

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“…Sijunzi and Siwu decoction, and is famous for enhancing both Qi and Xue, and balancing Yin and Yang. Thus, it is the one of the extensively used prescription for the intervention of sub-health status, and the prevention of aging-related degenerative diseases (1)(2)(3)(4).…”

mentioning

confidence: 99%

The Transcriptome Induced by Bazhen Decoction and its Function in G-quadruplex Resolving and Telomere Maintenance in Progeroid Cells

Tian

Yang

et al. 2023

Preprint

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Background The Bazhen decoction is one of the most extensively used Traditional Chinese medicine (TCM) prescriptions for anti-aging. However, due to the complicity of the components, the pharmacological mechanism of Bazhen decoction is still limited.Methods We applied RNA sequencing and transcriptome analysis to get the full view of the signaling pathways regulated by Bazhen decoction in the wild type cell background. By using the progeroid cells derived from Werner syndrome mice, we applied Western blot, Immunofluorescence, flow cytometry and telomere FISH to verify the transcriptome data.Results The transcriptome profile revealed that Bazhen decoction might systematically regulate multiple anti-aging pathways, including stem cell regulation, protein homeostasis, cardiovascular function, neuronal function, anti-inflammation, anti-DNA damage induced stress, DNA helicase activity and telomere lengthening. We found that multiple DNA helicases and telomere regulating proteins were up-regulated by Bazhen decoction, which promoted the resolving of G-quadruplex (G4) structure, and facilitated DNA replication and telomere elongation. These improvements also endowed the cellular resistance to DNA damages induced by replication stress. Together these data suggest that Bazhen decoction facilitate G4 resolving and telomere maintenance, which might contribute to the longevity sustaining properties revealed by transcriptome profile.Conclusions Our data revealed a new strategy for recovering the pharmacological signature pathways for TCM, which could help the clinical precision medicine of TCM. By applying transcriptome in TCM-treated normal cell, we tried out a systematic analysis for dissecting the molecular mechanism of complicated TCM prescription in the normal genetic background.

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Beneficial Effects of Traditional Chinese Medicine in the Treatment of Premature Ovarian Failure

Cited by 12 publications

References 66 publications

Research progress on the premature ovarian failure caused by cisplatin therapy

Research progress on the premature ovarian failure caused by cisplatin therapy

The Transcriptome Induced by Bazhen Decoction and its Function in G-quadruplex Resolving and Telomere Maintenance in Progeroid Cells

The Transcriptome Induced by Bazhen Decoction and its Function in G-quadruplex Resolving and Telomere Maintenance in Progeroid Cells

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