Beneficial effects of tea catechins on diet-induced obesity: stimulation of lipid catabolism in the liver

Murase, Takatoshi; Nagasawa, Azumi; Suzuki, Junko; Hase, Tadashi; Tokimitsu, Ichiro

doi:10.1038/sj.ijo.0802141

Cited by 442 publications

(415 citation statements)

References 26 publications

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“…In human experiments, consumption of green tea extract, which contains ECG, led to reduced secretion of TNF-α. 15 Furthermore, a study by Siddique et al 26 has demonstrated the protective role of ECG in a transgenic Drosophila model of Parkinson's disease due to its antioxidant and antiapoptotic effects. Tea polyphenols such as ECG have also been shown to inhibit proteasome function, thereby terminating inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…14 Gallocatechins have also been asserted to influence molecular targets in signal transduction pathways associated with inflammation, cell death, and survival. 15 In an in vitro study, ECG inhibited the production of pro-inflammatory cytokine, IL-1β, and enhanced the production of anti-inflammatory cytokines, IL-10, in human leukocytes. 16 Kim et al 17 showed that ECG attenuated ROS-induced oxidative stress in human nasal epithelial cells by inhibiting phosphorylation of ERK1/2 and epidermal growth factor receptor.…”

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confidence: 99%

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Molecular mechanisms underlying attenuation of cisplatin-induced acute kidney injury by epicatechin gallate

Malik

Suchal

Bhatia

et al. 2016

Laboratory Investigation

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Cisplatin, a platinum compound, is used as a first-line agent against various forms of solid cancers. Nephrotoxicity is an important adverse effect of cisplatin therapy, which involves increased oxidative stress, inflammation, apoptosis, and activation of the mitogen-activated protein kinase (MAPK) pathway. It is well known that the bioactive compounds present in green tea are used to treat various disorders due to their biological activities. With this background, the present study was aimed to investigate the effect of epicatechin gallate (ECG), a green tea polyphenol, in cisplatin-induced nephrotoxicity in rats. To achieve this, ECG (1.25, 2.5, and 5 mg/kg; intraperitoneal (i.p.)) was administered to male albino Wistar rats for the period of 10 days. On the 7th day, a single i.p. injection of cisplatin (8 mg/kg) was injected into rats to produce kidney injury and the animals were then killed on the 10th day. Cisplatin toxicity was associated with enhanced oxidative stress, impaired renal function along with marked tubular necrosis in Histopathology. Furthermore, cisplatin activated the MAPK pathway, which contributed to inflammation and apoptosis in the kidney of treated rats. In contrast, ECG (5 mg/kg) pretreatment normalized cisplatin-induced oxidative stress, renal function, and histopathological changes. ECG also prevented the activation of the MAPK pathway, and attenuated inflammation and apoptosis in rats. These findings suggest that ECG prevented cisplatin-induced oxidative stress, inflammation, and apoptosis by downregulating the MAPK pathway and resulted in improved renal function.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Molecular mechanisms underlying attenuation of cisplatin-induced acute kidney injury by epicatechin gallate

Malik

Suchal

Bhatia

et al. 2016

Laboratory Investigation

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“…Hence, an alternative approach that can reduce the food intake with minimal side effects emerged as another cautiously accepted choice in obesity control. 5,6 Platycodi Radix (Chinese Jiegeng, Japanese Kikyo, Korean Doraji) is the root of Platycodon grandiflorum A. De (Campanulaceae).…”

Section: Introductionmentioning

confidence: 99%

Antiobese and hypolipidemic effects of platycodin saponins in diet-induced obese rats: evidences for lipase inhibition and calorie intake restriction

Shim

et al. 2005

Int J Obes

123

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OBJECTIVE:To investigate how and to what extent platycodin saponin (PS) from Platycodi Radix exerts a favorable influence on obesity and hyperlipidemia. DESIGN: Sprague-Dawley rats were fed with a high fat (HF) diet for 4 weeks and then the animals were treated with 35 or 70 mg/kg of PS for another 4 weeks. Changes in body weight and daily calorie intake were measured regularly during the experimental period and the degree of linear correlation for the above two variables was further analyzed. The in vitro lipase inhibition of each PS compound and the in vivo fecal lipid excretion were examined in hope of revealing their relationship. The concentrations of hepatic triglyceride and cholesterol in serum. RESULTS: The body weight reduction (1374% vs HF control, Po0.05) by PS administration was highly correlated to the food intake restriction (Pearson's linear coefficient r ¼ 0.752, Po0.005). The in vitro inhibition of lipase by each isolated compound and mixture of PS were virtually identical. Consequently, the fecal TG excretion was increased by 2.1-3.2 folds depending on the dose of PS. The serum TG and LDL-cholesterol concentrations were decreased without noticeable changes in HDLcholesterol levels. Concomitantly, the contents of the hepatic TG, cholesterol, and the liver surface fat pads were decreased in ubiquity, but no noticeable biochemical abnormalities or histological tissue damages were observed. CONCLUSIONS: The administration of PS produced profound effects on the control of obesity and lipid metabolism, which resulted in LDL-cholesterol reduction. PS also caused a remarkable reduction in calorie intake, which was highly correlated to the body weight loss. These results suggest that PS has a greater role in antiobesity, hypolipidemia, and liver protection than previously thought. Hence, PS could be a potential therapeutic alternative in the treatment of obesity and hyperlipidemia.

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“…After 11 months of exposure to diets, mice fed a HF diet [30% (w/w)] supplemented with both 0.2 and 0.5% tea catechins had significantly lower weight gains, visceral fat accumulation, and liver fat accumulation in a dosedependent manner compared to the HF control group 99 . Moreover, both green tea catechin treatments suppressed elevation of plasma insulin levels in a dose-dependent manner compared to the HF control 99 .…”

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confidence: 96%

“…The effects of long-term exposure to green tea catechins on a dietinduced obese model were further explored by Murase et al 99 . After 11 months of exposure to diets, mice fed a HF diet [30% (w/w)] supplemented with both 0.2 and 0.5% tea catechins had significantly lower weight gains, visceral fat accumulation, and liver fat accumulation in a dosedependent manner compared to the HF control group 99 .…”

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confidence: 99%

Oligomeric Cocoa Procyanidins Possess Enhanced Bioactivity Compared to Monomeric and Polymeric Cocoa Procyanidins for Preventing the Development of Obesity, Insulin Resistance, and Impaired Glucose Tolerance during High-Fat Feeding

Dorenkott

Griffin

Goodrich

et al. 2014

J. Agric. Food Chem.

132

102

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Cocoa is a major source of these flavanols. However, research on the potential anti-obesity and anti-diabetic health benefits of cocoa flavanols is lacking in the literature. Furthermore, the effect that the size of these flavanols has on the extent of its beneficial properties is also unclear. The objective of this study was to evaluate the dietary effects of cocoa flavanols on the onset of obesity, insulin resistance and impaired glucose tolerance and to determine the impact that the size of these compounds has on the magnitude of this effect. Cocoa extract was fractionated into a monomer-, an oligomer-, and a polymer-rich fraction. Six groups (n=9) of C57BL/6J mice were fed either a control low-fat diet, a control high-fat diet, or a high-fat diet supplemented with 25 mg/kg*BW of cocoa extract or one of the three cocoa fractions. After 12 weeks on these diets, the oligomer-rich fraction proved to be most effective in preventing weight gain, fat mass accumulation, elevated fasting blood glucose and impaired glucose tolerance in diet-induced obese mice. This is the first long-term feeding study to examine the relative activities of cocoa constituents on diet-induced obesity and insulin resistance.iii Acknowledgements

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Beneficial effects of tea catechins on diet-induced obesity: stimulation of lipid catabolism in the liver

Cited by 442 publications

References 26 publications

Molecular mechanisms underlying attenuation of cisplatin-induced acute kidney injury by epicatechin gallate

Molecular mechanisms underlying attenuation of cisplatin-induced acute kidney injury by epicatechin gallate

Antiobese and hypolipidemic effects of platycodin saponins in diet-induced obese rats: evidences for lipase inhibition and calorie intake restriction

Oligomeric Cocoa Procyanidins Possess Enhanced Bioactivity Compared to Monomeric and Polymeric Cocoa Procyanidins for Preventing the Development of Obesity, Insulin Resistance, and Impaired Glucose Tolerance during High-Fat Feeding

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