Beneficial Effects of Silymarin Against Nephrotoxicity Caused by Some Chemicals

Иванов, Веселин; Славова, В.; Georgieva, D.; Petrova-Tacheva, V.; Toleкova, A.

doi:10.15547/tjs.2021.02.011

Cited by 1 publication

(2 citation statements)

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“…All chemicals were analytical grade (AR > 99.7%). The used silymarin was donated by Prof. V Ivanov, Trakia University, Stara Zagora, Bulgaria [17]. Vitamin E was purchased by Sigma Aldrich Pty Ltd., Merck KGaA, Sofia, Bulgaria.…”

Section: Plant Materials and Drugsmentioning

confidence: 99%

“…The search for other natural antioxidants with potential ferrostatic effects like silymarin (SM)-a bioactive extract from the plant Silybum marianum L. that contains flavonolignans like silybinin [13], will expand their clinical potential for ferroptosis-related known disorders. The potent antioxidant [14] and hepatoprotective effects [15] of silymarin, as well as its nephroprotective properties the extract [16,17], are well known. In the present study, we aimed to investigate the in vivo protective properties of vitamin E and SM against GN-induced nephrotoxicity and their relevance to accompanying oxidative changes.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Vitamin E and Silymarin Reduce Oxidative Tissue Damage during Gentamycin-Induced Nephrotoxicity

Georgiev,

Nikolova,

Dyakova

et al. 2023

Pharmaceuticals

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Aminoglycoside antibiotics and gentamicin (GN), in particular, are still widely used in clinical practice. It is a well-known fact that GN causes nephrotoxicity, and redox disturbances are discussed as a factor in its side effects. Recently, a new type of cell oxidative death, named ferroptosis, was discovered; it is associated with iron accumulation in the cell, glutathione (GSH) depletion and inactivation of glutathione peroxidase-4 (GPX4), reactive oxygen species (ROS) increment with concomitant lipid peroxidation. In this regard, a possible connection between GN-induced renal damage, ferroptosis and the overall antioxidant status of the organism could be investigated. Moreover, due to its beneficial effects, GN is still one of the main choices as a therapeutic agent for several diseases, and the possible reduction of its side effects with the application of certain antioxidants will be of important clinical significance. The study was conducted with adult male white mice divided into several groups (n = 6). GN nephrotoxicity was induced by the administration of GN 100–200 mg/kg i.p. for 10 days. The control group received only saline. The other groups received either Vitamin E (400 mg/kg p.o.) or Silymarin (200 mg/kg p.o.) applied alone or together with GN for the same period. After the end of the study, the animals were sacrificed, and blood and tissue samples were taken for the assessment of biochemical parameters and antioxidant status, as well as routine and specific for GPX4 histochemistry examination. The experimental results indicate that GN-induced nephrotoxicity negatively modulates GPX4 activity and is associated with increased production of ROS and lipid peroxidation. The groups treated with antioxidants demonstrated preserved antioxidant status and better GPX4 activity. In conclusion, the inhibition of ROS production and especially the suppression of ferroptosis, could be of clinical potential and can be applied as a means of reducing the toxic effects of GN application.

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Section: Plant Materials and Drugsmentioning

confidence: 99%