Beneficial Effects of Physical Training on the Cardio-Inflammatory Disorder Induced by Lung Ischemia/Reperfusion in Rats

Abstract

Our laboratory demonstrated that training program attenuated the inflammatory responses in lung ischemia/reperfusion (IR). Considering the importance of the inflammatory responses on the cardiovascular system, we evaluate the effect of physical training on the vascular responsiveness and its underlying mechanism after lung IR. Male Wistar rats were submitted to run training and lung IR. Concentration-response curves for relaxing and contracting agents were obtained. Protein expressions of SOD-1 and p47(phox), plasma nitritre/nitrate (NO (x) (-) ) and interleukin 6 (IL-6) were evaluated. A decreased in the potency for acetylcholine and phenylephrine associated with an upregulation of the p47(phox) expression were found after Lung IR as well as an increase in IL-6 and NO (x) (-) levels. Run training attenuated the vascular dysfunction that was accompanied by reduction of the p47(phox) protein expression and IL-6 levels. Our findings show the beneficial effect of training on the vascular function that was associated with reduction in inflammatory response in lung IR.

Influence of eNOS gene polymorphism on cardiometabolic parameters in response to physical training in postmenopausal women

“…Considering the relevance of exercise training in preventing or improving the deleterious effects of chronic diseases such as dyslipidemia and atherosclerosis, our data support our hypothesis that eNOS polymorphism at position -786T>C and Intron 4b/a interferes with the beneficial effects of 8 weeks of exercise training on cardiometabolic diseases in postmenopausal women. Regarding oxidative stress status, our data confirm previous results from our laboratory using an experimental model (29,30) showing that aerobic exercise promotes an improvement of antioxidant status by increasing plasma SOD levels, which in turn can ameliorate vascular and metabolic functions. In contrast, no change was found in thiobarbituric acid-reactive species concentrations in plasma measured as MDA in this particular population, showing that 8 weeks of exercise training did not modify the oxidant status.…”

Influence of Aerobic Training on the Reduced Vasoconstriction to Angiotensin II in Rats Exposed to Intrauterine Growth Restriction: Possible Role of Oxidative Stress and AT2 Receptor of Angiotensin II

“…Conversely, we found that the protein expression of the NADPH oxidase subunit p47 phox was higher in SRT rats, whereas aerobic exercise training was effective in normalizing p47 phox expression. Physical training performed prior to lung ischemia/reperfusion has been reported to be effective in normalizing p47 phox protein expression in mesenteric arteries [41] . p47 phox plays an important role in superoxide production in response to AngII [42] .…”