Beneficial effects of phosphatidylcholine on high-fat diet-induced obesity, hyperlipidemia and fatty liver in mice

Lee, Ho Sung; Nam, Yunsung; Chung, Yoon Hee; Kim, Hak Rim; Park, Eon Sub; Chung, Su Jin; Kim, Jung Hyo; Sohn, Uy Dong; Kim, Hyoung‐Chun; Oh, Keon Woong; Jeong, Ji Hoon

doi:10.1016/j.lfs.2014.09.027

Cited by 110 publications

(97 citation statements)

References 35 publications

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“…5 The results of this study are in agreement with previous findings of studies on mice fed high-fat diets. 2,44 The NAFLD is characterized by hepatic TG accumulation. It is caused by metabolic imbalance, which results from an increase in hepatic TGs and FFAs and a decrease in the release of TGs and FFAs from the liver.…”

Section: Discussionmentioning

confidence: 99%

“…The HDinduced obesity and NAFLD is associated with hyperlipidemia, which is caused by increased TGs, LDL, and TC. 2,44,53 Previous studies have demonstrated that inhibition of lipid accumulation is caused by the activation of b-oxidation and downregulation of fatty acid synthesis through the consumption of soybeans. 44,54 In addition, the studies reported that TG, TC, and HDL cholesterol levels are changed by increases in cholesterol and synthesis of bile acid.…”

Section: Discussionmentioning

confidence: 99%

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Hepatoprotective Effects of Soybean Embryo by Enhancing Adiponectin-Mediated AMP-Activated Protein KinaseαPathway in High-Fat and High-Cholesterol Diet-Induced Nonalcoholic Fatty Liver Disease

HongJihye

KimSera

KimHyun-Sook

2016

Journal of Medicinal Food

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Nonalcoholic fatty liver disease (NAFLD), which is characterized by >5% deposition of triglycerides in hepatocytes, is often referred as a major risk factor for obesity, type 2 diabetes, and hypertension. We investigated the hepatoprotective effect of whole soybean embryos containing bioactive substances such as isoflavones and soyasaponins. For this study, mice were randomly allocated into four groups that were fed different diets for 10 weeks: normal diets and high-fat and high-cholesterol diets (HD), and HD with 10% or 20% soybean embryo powder (10SE-HD and 20SE-HD). Hepatic superoxide dismutase and glutathione peroxidase activity of the experimental groups increased during the period of the study (P < .05). Hepatic mRNA expressions of tumor necrosis factor α, nuclear factor (erythroid-derived 2)-like 2, and Caspase 3 were decreased when soybean embryos were increased in the mice's diets. Both of the soybean embryo-treated groups showed significantly decreased serum and liver triglyceride and total cholesterol. Adiponectin, AMP-activated protein kinase (AMPK) α, hydroxymethylglutaryl-CoA reductase, sterol regulatory element-binding protein-1c, fatty acid synthase, and apolipoprotein B mRNA expressions were decreased in the mice that were fed soybean embryos. We suggest that the regular supplementation of soybean embryos might be a useful treatment for preventing NAFLD and associated complications through upregulation of adiponectin-mediated AMPKα pathway parameters, which are implicated in antioxidant, anti-inflammatory, and lipid metabolism activities.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hepatoprotective Effects of Soybean Embryo by Enhancing Adiponectin-Mediated AMP-Activated Protein KinaseαPathway in High-Fat and High-Cholesterol Diet-Induced Nonalcoholic Fatty Liver Disease

HongJihye

KimSera

KimHyun-Sook

2016

Journal of Medicinal Food

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“…In most of the species like yeast and plants, PC is a major acyl donor for triacylglycerol (TAG) synthesis via the activation of lecithin cholesterol acyltransferase (LRO1) (Dahlqvist et al 2000). The prominence of PC to health and disease was already proven by earlier studies (Farber et al 2000;Grothe et al 2015;Lee et al 2014). However, the metabolism under cellular stress remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Endoplasmic reticulum stress and calcium imbalance are involved in cadmium-induced lipid aberrancy in Saccharomyces cerevisiae

Rajakumar

Bhanupriya

Ravi

2016

Cell Stress and Chaperones

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The endoplasmic reticulum is the key organelle which controls protein folding, lipid biogenesis, and calcium (Ca 2+ ) homeostasis. Cd exposure in Saccharomyces cerevisiae activated the unfolded protein response and was confirmed by the increased Kar2p expression. Cd exposure in wild-type (WT) cells increased PC levels and the PC biosynthetic genes. Deletion of the two phospholipid methyltransferases CHO2 and OPI3 modulated PC, TAG levels and the lipid droplets with cadmium exposure. Interestingly, we noticed an increase in the calcium levels upon Cd exposure in the mutant cells. This study concluded that Cd interrupted calcium homeostasis-induced lipid dysregulation leading to ER stress.

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“…Soy was approved by many researchers to have an antiobesity effect because of its saponin, 11 protein, 12 and PC 13 content, so in this study, this anti-obesity action was investigated topically. Soy was extracted by continuous agitation method at 24°C, 15 then 12 soy phytosome formulations were prepared with three different techniques and characterized to optimize one formulation with the highest EE%, minimum Figure 6 Permeation profile of soy phytosomal thermogel with and without using penetration enhancers.…”

Section: Discussionmentioning

confidence: 99%

“…10 Soybean, Glycine max (L.) Merrill family Fabaceae, was known to have a significant effect on body weight control because of its content of saponin, 11 protein, 12 and phosphatidylcholine (PC). 13 However, the mechanism is still unexplained. 14 In this study, the effect of soy phytosomal thermogel in controlling high-fat diet (HFD)-induced weight gain was investigated in experimental albino rats.…”

Section: El-menshawe Et Almentioning

confidence: 99%

Nanosized soy phytosome-based thermogel as topical anti-obesity formulation: an approach for acceptable level of evidence of an effective novel herbal weight loss product

El-Menshawe

Ali

Rabeh

et al. 2018

IJN

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Purpose Herbal supplements are currently available as a safer alternative to manage obesity, which has become a rising problem over the recent years. Many chemical drugs on the market are designed to prevent or manage obesity but high cost, low efficacy, and multiple side effects limit its use. Nano lipo-vesicles phytosomal thermogel of Soybean, Glycine max ( L .) Merrill, was formulated and evaluated in an attempt to investigate its anti-obesity action on body weight gain, adipose tissue size, and lipid profile data. Methods Three different techniques were used to prepare phytosome formulations including solvent evaporation, cosolvency, and salting out. The optimized phytosome formulation was then selected using Design Expert ® (version 7.0.0) depending on the highest entrapment efficiency, minimum particle size (PS), and maximum drug release within 2 hours as responses for further evaluation. The successful phytosome complex formation was investigated by means of Fourier-transform infrared spec troscopy and determination of PS and zeta potential. Phytosome vesicles’ shape was evaluated using transmission electron microscope to ensure its spherical shape. After characterization of the optimized phytosome formulation, it was incorporated into a thermogel formulation. The obtained phytosomal thermogel formulation was evaluated for its clarity, homogeneity, pH, and gel transformation temperature besides rheology behavior and permeation study. An in vivo study was done to investigate the anti-weight-gain effect of soy phytosomal ther mogel. Results EE was found to be >99% for all formulations, PS ranging from 51.66–650.67 while drug release was found to be (77.61–99.78) in range. FTIR and TEM results confirmed the formation of phytosome complex. In vivo study showed a marked reduction in body weight, adipose tissue weight and lipid profile. Conclusion Concisely, soy phytosomal thermogel was found to have a local anti-obesity effect on the abdomen of experimental male albino rats with a slight systemic effect on the lipid profile data.

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Beneficial effects of phosphatidylcholine on high-fat diet-induced obesity, hyperlipidemia and fatty liver in mice

Cited by 110 publications

References 35 publications

Hepatoprotective Effects of Soybean Embryo by Enhancing Adiponectin-Mediated AMP-Activated Protein KinaseαPathway in High-Fat and High-Cholesterol Diet-Induced Nonalcoholic Fatty Liver Disease

Hepatoprotective Effects of Soybean Embryo by Enhancing Adiponectin-Mediated AMP-Activated Protein KinaseαPathway in High-Fat and High-Cholesterol Diet-Induced Nonalcoholic Fatty Liver Disease

Endoplasmic reticulum stress and calcium imbalance are involved in cadmium-induced lipid aberrancy in Saccharomyces cerevisiae

Nanosized soy phytosome-based thermogel as topical anti-obesity formulation: an approach for acceptable level of evidence of an effective novel herbal weight loss product

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