Beneficial effects of omega-3 and vitamin E coadministration on gene expression of SIRT1 and PGC1α and serum antioxidant enzymes in patients with coronary artery disease

Saboori, Somayeh; Koohdani, Fariba; Nematipour, Ebrahim; Rad, Esmaeil Yousefi; Saboor-Yaraghi, Ali-Akbar; Javanbakht, Mohammad Hassan; Eshraghian, M R; Ramezani, Atena; Djalali, Mahmoud

doi:10.1016/j.numecd.2015.11.013

Cited by 40 publications

(14 citation statements)

References 44 publications

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“…The study of Tang et al performed on iron-deficient infants and toddlers was excluded as well 60 . Moreover, two eligible articles were published on the same dataset 35,61 , of which the more complete one was included 35 and the other one was excluded 61 . After these exclusions, 33 eligible RCTs remained for inclusion in the current systematic review and meta-analysis ; out of them, 26 studies assessed serum concentrations of CRP 11,[13][14][15][16][17][18][19][20]22,[25][26][27][28][29][30][31][33][34][35]37,38,[40][41][42][43] , 14 studies assessed serum concentrations of IL-6 17,[20][21][22][23][26][27][28][29][30][31]33,37,38 , and 12 studies evaluated serum concentrations of tumor necrosis factor-α (TNF-α) following vitamin E supplementation 12,…”

Section: Resultsmentioning

confidence: 99%

The effect of vitamin E supplementation on selected inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials

Asbaghi

Sadeghian

Nazarian

et al. 2020

Sci Rep

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The previous meta-analysis of clinical trials revealed a beneficial effect of vitamin E supplementation on serum C-reactive protein (CRP) concentrations; however, it is unknown whether this vitamin has the same influence on other inflammatory biomarkers. Also, several clinical trials have been published since the release of earlier meta-analysis. Therefore, we aimed to conduct a comprehensive meta-analysis to summarize current evidence on the effects of vitamin E supplementation on inflammatory biomarkers in adults. We searched the online databases using relevant keywords up to November 2019. Randomized clinical trials (RCTs) investigating the effect of vitamin E, compared with the placebo, on serum concentrations of inflammatory cytokines were included. Overall, we included 33 trials with a total sample size of 2102 individuals, aged from 20 to 70 years. Based on 36 effect sizes from 26 RCTs on serum concentrations of CRP, we found a significant reduction following supplementation with vitamin E (− 0.52, 95% CI − 0.80, − 0.23 mg/L, P < 0.001). Although the overall effect of vitamin E supplementation on serum concentrations of interleukin-6 (IL-6) was not significant, a significant reduction in this cytokine was seen in studies that used α-tocopherol and those trials that included patients with disorders related to insulin resistance. Moreover, we found a significant reducing effect of vitamin E supplementation on tumor necrosis factor-α (TNF-α) concentrations at high dosages of vitamin E; such that based on dose–response analysis, serum TNF-α concentrations were reduced significantly at the dosages of ≥ 700 mg/day vitamin E (Pnon-linearity = 0.001). Considering different chemical forms of vitamin E, α-tocopherol, unlike other forms, had a reducing effect on serum levels of CRP and IL-6. In conclusion, our findings revealed a beneficial effect of vitamin E supplementation, particularly in the form of α-tocopherol, on subclinical inflammation in adults. Future high-quality RCTs should be conducted to translate this anti-inflammatory effect of vitamin E to the clinical setting.

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Section: Resultsmentioning

confidence: 99%

The effect of vitamin E supplementation on selected inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials

Asbaghi

Sadeghian

Nazarian

et al. 2020

Sci Rep

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“…Similar to omega-7, omega-3 unsaturated fatty acids inhibit inflammation by activating the SIRT1 pathway in mouse microglia cells [11]. In addition, omega-3 has demonstrated to increase SIRT1 gene expression in coronary artery disease as well as to generate antioxidant effects [12]. Likewise, omega-9 unsaturated fatty acids have been shown to ascent rates of complete fatty acid oxidation by SIRT1-PGC1a complex activation in skeletal muscle cells [13].…”

Section: Introductionmentioning

confidence: 99%

Omega-7 inhibits inflammation and promotes collagen synthesis through SIRT1 activation

Song

Han

et al. 2018

Appl Biol Chem

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Excessive accumulation of reactive oxygen species (ROS) during oxidative stress accelerates the skin aging process. ROS stimulate inflammatory processes in the skin, leading to activation of matrix metalloprotease-1 (MMP-1). Silent information regulator 1 (SIRT1) controls a broad range of cellular functions including the expression of MMP-1. Omega-7 fatty acids such as palmitoleic acid have many beneficial effects on health, including improvement in cardiovascular risk factors and increased insulin sensitivity. However, the effectiveness of omega-7 fatty acids (herein referred to as omega-7) related to skin aging, characterized by the degradation of collagen and loss of elasticity, remains unclear. We here investigated the effects of palmitoleic acid, a representative omega-7, on collagen regeneration through its ability to activate SIRT1 and inhibit MMP-1 in the presence of hydrogen peroxide (H 2 O 2 )-induced oxidative stress in human HaCaT cells. SIRT1 activation by omega-7 decreased signaling levels of nuclear transcription factor kappa B (NF-jB) and inflammatory cytokines. However, inhibition of SIRT1 by sirtinol counteracted the advantage effects of omega-7 in H 2 O 2treated HaCaT cells. In addition, omega-7 significantly counteracted the decrease in collagen abundance and loss of elasticity induced by H 2 O 2 . Consistent with this observation, omega-7 significantly decreased H 2 O 2 -induced upregulation of MMP-1 in HaCaT cells. Together, these studies suggest the potential efficacy of SIRT1 in collagen regeneration and indicate that omega-7 is a possible functional food to improve skin health for the prevention of aging.

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“…A significant inverse association of vitamin E and hsCRP has been demonstrated in some studies (55,56) . A previous study reported that the consumption of vitamin E and omega-3 fatty acid can increase the expression of SIRT1 and PGC1a genes, suppressing pro-inflammatory genes in coronary artery disease patients (57) .…”

Section: Fto Rs9930506 and Interaction With Biochemical Parameters Anmentioning

confidence: 95%

Effect of FTO rs9930506 on obesity and interaction of the gene variants with dietary protein and vitamin E on C‐reactive protein levels in multi‐ethnic Malaysian adults

Mitra

Tan

Amini

2018

J Human Nutrition Diet

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Beneficial effects of omega-3 and vitamin E coadministration on gene expression of SIRT1 and PGC1α and serum antioxidant enzymes in patients with coronary artery disease

Cited by 40 publications

References 44 publications

The effect of vitamin E supplementation on selected inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials

The effect of vitamin E supplementation on selected inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials

Omega-7 inhibits inflammation and promotes collagen synthesis through SIRT1 activation

Effect of FTO rs9930506 on obesity and interaction of the gene variants with dietary protein and vitamin E on C‐reactive protein levels in multi‐ethnic Malaysian adults

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