Beneficial effects of oleuropein on glucose uptake and on parameters relevant to the normal homeostatic mechanisms of glucose regulation in rat skeletal muscle

Alkhateeb, Hakam; Al-Duais, Mohammed; Qnais, Esam

doi:10.1002/ptr.6012

Cited by 17 publications

(15 citation statements)

References 28 publications

(49 reference statements)

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“…These findings were confirmed by human clinical trial results showing that treatment with Ole improved glucose homeostasis, reduced glycated hemoglobin and fasting insulin levels, suggesting a significant anti-diabetic effect [77][78][79]. Interestingly, in the context of these latter metabolic disorders, both characterized by insulin-resistance, de BocK et al [78] showed a recovery of insulin sensitivity and pancreatic β-cell secretion capacity, in a group of overweight middle-aged men that received capsules of oleuropein-leaf extracts for 12 weeks, corroborating previous findings on the hypoglycemic effect of oleuropein [41,71,80].…”

Section: Lipid-regulating Anti-hypertensive and Antidiabetic Effectssupporting

confidence: 71%

Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

et al. 2019

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Growing scientific literature data suggest that the intake of natural bioactive compounds plays a critical role in preventing or reducing the occurrence of human chronic non-communicable diseases (NCDs). Oleuropein, the main phenolic component of Olea europaea L., has attracted scientific attention for its several health beneficial properties such as antioxidant, anti-inflammatory, cardio- and neuro-protective, and anti-cancer. This article is a narrative review focused on the current literature concerning the effect of oleuropein in NCDs, such as neuro- and cardiovascular diseases, diabetes mellitus, chronic kidney diseases, and cancer, by its putative antioxidant and anti-inflammatory activity, but also for its other peculiar actions such as an autophagy inducer and amyloid fibril growth inhibitor and, finally, for its anti-cancer effect. Despite the increasing number of published studies, looking at the beneficial effects of oleuropein, there is limited clinical evidence focused on the benefits of this polyphenol as a nutraceutical product in humans, and many problems are still to be resolved about its bioavailability, bioaccessibility, and dosage. Thus, future clinical randomized trials are needed to establish the relation between the beneficial effects and the mechanisms of action occurring in the human body in response to the intake of oleuropein.

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Section: Lipid-regulating Anti-hypertensive and Antidiabetic Effectssupporting

confidence: 71%

Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

et al. 2019

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“…Oleuropein has been implicated to improve postprandial glycemic profile via hampering NOX 2 -derived oxidative stress (R. Carnevale et al, 2018). These results were further consolidated ex vivo study (Alkhateeb, Al-Duais, & Qnais, 2018). Considering that T2D pathogenesis involves peripheral glucose uptake dysfunction, oleuropein may play a role in both treatment and prevention.…”

Section: Antidiabetic Effects Of Oleuropeinmentioning

confidence: 87%

Oleuropein: A natural antioxidant molecule in the treatment of metabolic syndrome

Ahamad

Toufeeq

Khan

et al. 2019

Phytotherapy Research

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Olive (Olea europaea Linn., Fam. Oleaceae) is commonly known as Zaytoon in Mediterranean region. Its fruits and oil are essential components of Mediterranean diets. Olive tree is a prevalent plant species and one of the important cultivated crops of Mediterranean region. Oleuropein is a phenolic constituents of olive, which, along with its related compounds, has been indicated to be majorly responsible for its beneficial effects. Oleuropein is a secoiridoid type of phenolic compound and consists of three structural subunits: hydroxytyrosol, elenolic acid, and a glucose molecule. It is also reported to be the chemotaxonomic marker of olive. The oleuropein is reported to possess a number of biological activities including action against dyslipidemia, antiobesity, antidiabetic, antioxidant, antiatherogenic, antihypertensive, antiinflammatory, and hepatoprotective actions. The scientific evidence supports the role of oleuropein as a potential agent against metabolic syndrome. The present review discusses chemistry of oleuropein along with potential role of oleuropein with reference to pathophysiology of metabolic syndrome.

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“…In recent years, the importance of the antioxidant capacity of 3,4-DHPEA-EA and its derivatives [9][10] in relation to skeletal muscle has emerged [11][12][13]. Skeletal muscle is a tissue in which ROS are of particular importance: at low concentrations ROS act as signaling molecules in signal transduction pathways; instead, at high concentrations they can induce oxidative stress and muscular atrophy [14].…”

Section: Introductionmentioning

confidence: 99%

Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-mediated Cytotoxicity in C2C12 Myocytes Via Inactivation of p-JNK/p-c-Jun Signaling Pathway

Nardi¹,

Baldelli²,

Ciriolo³

et al. 2020

Preprint

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Oleuropein, glycosylated secoiridoid present in olive leaves is known to be an important antioxidant phenolic compound. We studied the antioxidant effect of low doses of oleuropein aglycone (3,4-DHPEA-EA) and oleuropein aglycone peracetylated (3,4-DHPEA-EA(P)) in murine C2C12 myocytes treated with hydrogen peroxide (H2O2). Both compounds were used at a concentration of 10 μM and were able to inhibit cell death induced by the H2O2 treatment, with 3,4-DHPEA-EA(P) being more. Under our experimental conditions, H2O2 efficiently induced the phosphorylated-active form of JNK and of its downstream target c-Jun. We demonstrated, by Western blot analysis, that 3,4-DHPEA-EA(P) was efficient in inhibiting the phospho-active form of JNK. This data suggests that the growth arrest and cell death of C2C12 proceeds via the JNK/c-Jun pathway. Moreover, we demonstrated that 3,4-DHPEA-EA(P) affects the myogenesis of C2C12 cells; because MyoD mRNA levels and the differentiation process are restored with 3,4-DHPEA-EA(P) after treatment. Overall, the results indicate that 3,4-DHPEA-EA(P) prevents ROS-mediated degenerative process in a genomic and epigenomic manner by functioning as an efficient antioxidant.

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Beneficial effects of oleuropein on glucose uptake and on parameters relevant to the normal homeostatic mechanisms of glucose regulation in rat skeletal muscle

Cited by 17 publications

References 28 publications

Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

Oleuropein: A natural antioxidant molecule in the treatment of metabolic syndrome

Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-mediated Cytotoxicity in C2C12 Myocytes Via Inactivation of p-JNK/p-c-Jun Signaling Pathway

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