Beneficial effects of melatonin on serum nitric oxide, homocysteine, and ADMA levels in fructose-fed rats

Kantar, Şerife; Türközkan, Nurten; Bircan, Filiz Sezen; Paşaoğlu, Özge Tuğçe

doi:10.3109/13880209.2014.957782

Cited by 26 publications

(12 citation statements)

References 48 publications

(61 reference statements)

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“…These observations are consistent with the data of Lee et al. and confirm the association between melatonin and NO as observed in animals , as well as the association of melatonin, NO and SA in plant innate immunity (Fig. ).…”

Section: Discussionsupporting

confidence: 93%

“…We noticed that melatonin‐activated SA accumulation is essential for melatonin‐triggered defense responses against pathogen attack in Arabidopsis , indicating the direct relation between melatonin and SA in plant immunity. Recently, the association between melatonin and NO has been observed in animals , this association has not been explored in plants. Moreover, the relation between melatonin and SA as well as the link of NO and SA, also suggested the possible association among these molecules.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Melatonin induces nitric oxide and the potential mechanisms relate to innate immunity against bacterial pathogen infection in Arabidopsis

Shi

Chen

Tan

et al. 2015

Journal of Pineal Research

219

189

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Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring small molecule, serving as important secondary messenger in the response of plants to various biotic and abiotic stresses. However, the interactions between melatonin and other important molecules in the plant stress response, especially in plant immunity, are largely unknown. In this study, we found that both melatonin and nitric oxide (NO) levels in Arabidopsis leaves were significantly induced by bacterial pathogen (Pst DC3000) infection. The elevated NO production was caused by melatonin as melatonin application enhanced endogenous NO level with great efficacy. Moreover, both melatonin and NO conferred improved disease resistance against Pseudomonas syringe pv. tomato (Pst) DC3000 infection in Arabidopsis. NO scavenger significantly suppressed the rise of NO which was induced by exogenous application of melatonin. As a result, the beneficial effects of melatonin on the expression of salicylic acid (SA)-related genes and disease resistance against bacterial pathogen infection were jeopardized by use of a NO scavenger. Consistently, melatonin application significantly lost its effect on the innate immunity against P. syringe pv. tomato (Pst) DC3000 infection in NO-deficient mutants of Arabidopsis. The results indicate that melatonin-induced NO production is responsible for innate immunity response of Arabidopsis against Pst DC3000 infection.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Melatonin induces nitric oxide and the potential mechanisms relate to innate immunity against bacterial pathogen infection in Arabidopsis

Shi

Chen

Tan

et al. 2015

Journal of Pineal Research

219

189

View full text Add to dashboard Cite

show abstract

“…Although some studies have shown that MT and NO can improve the resistance of plants to pathogens, their effect on ricevirus interactions remains elusive [11,13,36]. Recently, the association between MT and NO in disease resistance has been reported not only in animals but also in plants [13,37]. Consistent with these studies, we found that NO participates in MT triggered rice resistance to RSV.…”

Section: Discussionsupporting

confidence: 89%

Melatonin is responsible for rice resistance to rice stripe virus infection through a nitric oxide-dependent pathway

Liu

Shao

et al. 2019

Virol J

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Rice stripe virus (RSV) causes one of the most important rice virus diseases of plants in East Asia. However, the molecular mechanisms controlling rice resistance to RSV infection are largely unknown. Recently, several studies presented a novel model that melatonin (MT) and nitric oxide (NO) participate in the plant-pathogen interaction in a synergetic manner. In this study, there was a difference in MT content between two rice varieties that correlated with one being susceptible and one being resistant to RSV, which suggested that MT is related to RSV resistance. In addition, a test with two NO biosynthesis inhibitors revealed that NO inhibitor were able to increase the disease incidence of RSV. A pharmacological experiment with exogenous MT and NO showed that increased MT and NO in the MT-pretreated plants led to lower disease incidences; however, only NO increased in a NO-releasing reagent [sodium nitroprusside (SNP)] pretreated plants. The expressions level of OsPR1b and OsWRKY 45 were significantly induced by MT and NO. These results suggest that rice resistance to RSV can be improved by increased MT through a NO-dependent pathway.

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“…In animal studies, continuous light exposure or pinealectomy with a subsequent melatonin deficiency (Brown et al, 1991 ; Iigo et al, 1995 ) results in an increase in blood pressure (BP), a condition which is reversed by melatonin supplementation (Simko et al, 2014b ). A similar finding is also reported in spontaneous hypertensive (Tain et al, 2010 ) and metabolic syndrome (Kantar et al, 2015 ) rats supplemented with melatonin, thereby confirming its therapeutic potential in hypertension.…”

Section: Evidence For Cardiovascular Benefits Of Endogenous Melatoninsupporting

confidence: 84%

Cardiovascular Benefits of Dietary Melatonin: A Myth or a Reality?

2018

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The role of the diet as well as the impact of the dietary habits on human health and disease is well established. Apart from its sleep regulatory effect, the indoleamine melatonin is a well-established antioxidant molecule with multiple health benefits. Convincing evidence supports the presence of melatonin in plants and foods with the intake of such foods affecting circulating melatonin levels in humans. While numerous actions of both endogenous melatonin and melatonin supplementation are well described, little is known about the influence of the dietary melatonin intake on human health. In the present review, evidence for the cardiovascular health benefits of melatonin supplementation and dietary melatonin is discussed. Current knowledge on the biological significance as well as the underlying physiological mechanism of action of the dietary melatonin is also summarized. Whether dietary melatonin constitutes an alternative preventive treatment for cardiovascular disease is addressed.

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Beneficial effects of melatonin on serum nitric oxide, homocysteine, and ADMA levels in fructose-fed rats

Cited by 26 publications

References 48 publications

Melatonin induces nitric oxide and the potential mechanisms relate to innate immunity against bacterial pathogen infection in Arabidopsis

Melatonin induces nitric oxide and the potential mechanisms relate to innate immunity against bacterial pathogen infection in Arabidopsis

Melatonin is responsible for rice resistance to rice stripe virus infection through a nitric oxide-dependent pathway

Cardiovascular Benefits of Dietary Melatonin: A Myth or a Reality?

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