Beneficial effects of <i>Lactobacillus</i>-fermented black barley on high fat diet-induced fatty liver in rats

Qi, Guijun; XianBin, Ding; Zhong, Lingyue; Zhu, Chuang; Nie, Pan; Liu, Song

doi:10.1039/d1fo00290b

Cited by 15 publications

(16 citation statements)

References 38 publications

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“…Our results show that the functional components (polyphenol, flavone) were enhanced by KBF. Previous studies have also proved fermented grains could enrich certain functional components after fermentation, such as barley or black barley with probiotics and kidney beans fermented with Pleurotus ostreatus [ 9 , 33 ]. This may be because probiotic fermentation promotes the release of polyphenols and flavonoids in raw kidney beans.…”

Section: Discussionmentioning

confidence: 99%

“…A number of studies have confirmed that the proportion of polyphenols that are enriched after fermentation intake should be increased in a reasonable diet structure to prevent hyperlipidemia, and the functional components play a potential hypolipidemia-lowering effect through different regulatory mechanisms [ 8 , 9 ]. For example, flavonoids in oats inhibit fat production and promote its decomposition [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Food fermented with probiotics could increase the diversity of intestinal flora, regulate the homeostasis of intestinal flora, participate in the regulation of lipid, glucose, and energy metabolism, and then reduce blood lipids, improve health, and inhibit the growth of harmful bacteria in the intestinal tract [ 22 , 23 ]. Current studies have shown that the content of flavonoids or polyphenols increased with probiotic fermentation by regulating intestinal microbial abundance to reduce hyperlipidemia induced by a high-fat diet [ 9 , 24 ]. Nevertheless, there are few reports on the mechanism of whether probiotics in fermented kidney bean liquid can regulate the intestinal microbial community structure in hyperlipidemia.…”

Section: Introductionmentioning

confidence: 99%

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Kidney Bean Fermented Broth Alleviates Hyperlipidemic by Regulating Serum Metabolites and Gut Microbiota Composition

et al. 2022

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Hyperlipidemia with fat accumulation and weight gain causes metabolic diseases and endangers human body health easily which is accompanied by metabolic abnormalities and intestinal flora disorders. In this study, the kidney bean fermented broth (KBF) was used in rats that were fed a high-fat diet to induce hyperlipidemia in order to subsequently analyse the serum metabolomics and gut microbiota modulatoration. The results show that the contents of the total polyphenols and total flavonoids in the KBF were up three and one times, while energy and carbohydrates decreased. In the HFD-induced hyperlipidemic model, body weight, organ weight, and the level of blood lipids (ALT, AST, TG, TC) were lower in rats treated with KBF than in the controls. Metabonomics indicate that there were significant differences in serum metabolomics between the KBF and the HFD. KBF could significantly improve the glycerophospholipids, taurine, and hypotaurine metabolism and amino acid metabolism of hyperlipidemic rats and then improve the symptoms of hypersterol and fat accumulation in rats. The relative abundance of beneficial bacteria increased while pathogenic bacteria decreased after the intervention of KBF. KBF ameliorates dyslipidemia of HFD-induced hyperlipidemic via modulating the blood metabolism and the intestinal microbiota. Collectively, these findings suggest that KBF could be developed as a functional food for anti-hyperlipidemia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Kidney Bean Fermented Broth Alleviates Hyperlipidemic by Regulating Serum Metabolites and Gut Microbiota Composition

et al. 2022

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“…These changes result from the microbial metabolic activities that mainly break down carbohydrate fractions into several end products, such as acids. The presence of multiple end products and the release of several phytochemicals deliver various health-promoting properties, such as the prevention of cardiovascular disease [ 11 ], hypertension [ 12 , 13 , 14 , 15 ], obesity [ 16 , 17 ], and osteoporosis [ 18 ]. In addition, a variety of fermented foods have shown antidiabetic effects both in vitro and in vivo [ 6 ] using a wide range of different microorganisms as starter cultures.…”

Section: Introductionmentioning

confidence: 99%

Ameliorative and Antioxidative Potential of Lactobacillus plantarum-Fermented Oat (Avena sativa) and Fermented Oat Supplemented with Sidr Honey against Streptozotocin-Induced Type 2 Diabetes in Rats

2022

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The ameliorative and antioxidative stress effects of probiotic-enriched fermented oat (FOE) or fermented oat with honey (HFOE) extracts on streptozotocin-induced diabetes in rats were examined. The total phenolic content (TPC) and antioxidant activity (AOA) were increased in FOE and HFOE after 72 h of fermentation, and γ-aminobutyric acid (GABA) reached 7.35 mg 100 g−1 in FOE and 8.49 mg 100 g−1 in HFOE. The β-glucan levels were slightly decreased to 2.45 g 100 g−1 DW in FOE and 2.63 g 100 g−1 DW in HFOE. The antidiabetic and hypolipidemic properties of FOE and HFOE were studied in a designed animal model with seven treated groups for 6 weeks. Groups were treated as follows: group 1 (negative group, NR) and group 2 (diabetic rats, DR) were administered 7 mL distilled water orally per day; group 3 (DR + MET) rats were orally administered 50 mg standard drug Metformin kg−1 daily; group 4 (DR + FOE1) diabetic rats were orally administered 3.5 mL FOE daily; group 5 (DR + FOE2) rats were orally administered 7 mL FOE daily; group 6 (DR + HFOE1) rats were orally administered 3.5 mL HFOE daily; and group 7 (DR + HFOE2) rats were orally administered 7 mL HFOE daily. The HFOE at the high dose had a synergistic effect, lowering random blood glucose (RBG) and fasting blood glucose (FBG). The hypolipidemic potential of HFOE at the high dose was indicated by significant reductions in triglycerides (TG), total cholesterol (CHO), high- and low-density lipoproteins (HDL and LDL), and very-low-density lipoproteins (VLDL). In addition, 7 mL of HFOE improved liver and kidney function more effectively than other fermented extracts or Metformin. As well as the antioxidant enzyme activity, reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and malonaldehyde (MDA) were significantly enhanced after the administration of HFOE at 7 mL by 68.6%, 71.5%, 55.69%, and 15.98%, respectively, compared to the DR group. In conclusion, administration of L. plantarum-fermented oats supplemented with honey demonstrated antidiabetic effects and a potential approach for controlling glucose levels and lipid profiles, and protecting against oxidative stress.

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“…Nucleotides are important low-molecular-weight compounds that participate in the regulation and metabolism of various substances as free nucleotides or their derivatives ( Wang et al, 2021a ; Guan et al, 2021 ; Lu et al, 2021 ; Santos Ferreira et al, 2021 ). Free mononucleotides are the main high-energy compounds involved in energy metabolism, important messengers in cellular signal transduction, and metabolic regulators of various nutrients in the body ( Wang et al, 2021a ; Guan et al, 2021 ; Lu et al, 2021 ; Santos Ferreira et al, 2021 ). Addition of exogenous nucleotides can nourish lymphocytes, promote their differentiation, and inhibit DNA damage.…”

Section: Introductionmentioning

confidence: 99%

A Single Nucleotide Mixture Enhances the Antitumor Activity of Molecular-Targeted Drugs Against Hepatocellular Carcinoma

Mao

Jiang

et al. 2022

Front. Pharmacol.

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New strategies for molecular-targeted drug therapy for advanced hepatocellular carcinoma (HCC) ignore the contribution of the nutritional status of patients and nutritional support to improve physical status and immunity. We aimed to elucidate the role of a single nucleotide mixture (SNM) in the anti-tumor therapy of HCC, and to explore the importance of a SNM as adjuvant therapy for HCC. Compared with a lipid emulsion (commonly used nutritional supplement for HCC patients), the SNM could not induce metabolic abnormalities in HCC cells (Warburg effect), and did not affect expression of metabolic abnormality-related factors in HCC cells. The SNM could also attenuate the lymphocyte injury induced by antitumor drugs in vitro and in vivo, and promote the recruitment and survival of lymphocytes in HCC tissues. Using HCC models in SCID (server combined immune-deficiency) mice or BalB/c mice, the SNM had anti-tumor activity, and could significantly upregulate the antitumor activity of molecular-targeted drugs (tyrosine-kinase inhibitors [TKI] and immune-checkpoint inhibitors [ICI]) against HCC. We employed research models in vivo and in vitro to reveal the anti-tumor activity of the SNM on HCC. Our findings expand understanding of the SNM and contribute to HCC (especially nutritional support) therapy.

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Beneficial effects of Lactobacillus-fermented black barley on high fat diet-induced fatty liver in rats

Abstract: Long term high-fat diet (HF) can cause metabolic disorders, which might induce fatty liver. Fermented whole cereal food exhibit healthy potential due to their unique phytochemical composition and probiotics. In...

Cited by 15 publications

References 38 publications

Kidney Bean Fermented Broth Alleviates Hyperlipidemic by Regulating Serum Metabolites and Gut Microbiota Composition

Kidney Bean Fermented Broth Alleviates Hyperlipidemic by Regulating Serum Metabolites and Gut Microbiota Composition

Ameliorative and Antioxidative Potential of Lactobacillus plantarum-Fermented Oat (Avena sativa) and Fermented Oat Supplemented with Sidr Honey against Streptozotocin-Induced Type 2 Diabetes in Rats

A Single Nucleotide Mixture Enhances the Antitumor Activity of Molecular-Targeted Drugs Against Hepatocellular Carcinoma

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