Beneficial effects of<i>Dendrobium officinale</i>on metabolic hypertensive rats by triggering the enteric-origin SCFA-GPCR43/41 pathway

Li, Bo; He, Xinglishang; Jin, Haiying; Wang, Huiying; Zhou, Fu-Chen; Zhang, Ning-Yu; Dong-ying, Jie; Li, Linzi; Shi, Jie; Zheng, Xiang; Luo, Rong; Lv, Gui‐Yuan; Jiang, Ning-Hua; Yu, Qiao-Xian; Chen, Suhong

doi:10.1039/d0fo02890h

Cited by 23 publications

(29 citation statements)

References 29 publications

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“…When vascular injury leads to endothelial dysfunction, NO synthesis decreases and ET-1 secretion increases, and this contributes to hypertension (Monica ET al., 2016;Wong et al, 2013). Our team previously found vascular endothelial injury in MH rats, and the expression of eNOS protein in the vessel and the NO level in the serum were significantly decreased (Li et al, 2021). Here, the plasma levels of eNOS and NO in MH rats were decreased, and the ET-1 level was increased, which was consistent with the previous results.…”

Section: Discussionsupporting

confidence: 90%

“…Zhu et al suggested that an unhealthy diet is the initial culprit (Zhu et al, 2013). Thus, we established an MH model by induction with ACHSFD, which appears to simulate the unhealthy diets in many humans (Chen et al, 2015;Li et al, 2021). We found that several phenomena in the MH rats were similar to those in human MH patients, including high blood pressure and increasing of serum lipid levels and markers of liver damage.…”

Section: Discussionmentioning

confidence: 73%

“…The pathogenesis of MH is complex; the gastrointestinal tract is considered to be the initial organ of onset (Li et al, 2021), and intestinal LPS is the key factor driving MH. LPS is released from cell walls of dead Gram-negative bacteria such as Desulfovibrio (Qureshi et al, 1999) and is cleared by the liver (Szabo and Bala.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, pathophysiological mechanisms underlying MH are complex, inhibiting the development of targeted treatments. MH is known to be associated with unhealthy dietary behaviors, such as the indulgence in over-consumption of alcohol, high sugar and fat diets (ACHSFDs), as these behaviors correlate with the occurrence and development of hypertension (Zhu et al, 2016;Li et al, 2021). Importantly recent studies have identified the significance of the gastrointestinal tract, as the initial barrier for the entry of exogenous substances such as alcohol and fat into the body, in links between diet and MH (Zhu et al, 2016;Li et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…MH is known to be associated with unhealthy dietary behaviors, such as the indulgence in over-consumption of alcohol, high sugar and fat diets (ACHSFDs), as these behaviors correlate with the occurrence and development of hypertension (Zhu et al, 2016;Li et al, 2021). Importantly recent studies have identified the significance of the gastrointestinal tract, as the initial barrier for the entry of exogenous substances such as alcohol and fat into the body, in links between diet and MH (Zhu et al, 2016;Li et al, 2021). The gastrointestinal tract is not only the location of digestion and absorption, but it is also involved in the regulation of cardiovascular metabolism, and it thus may be the organ of initiation of MH (Zhu et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Buddleoside-Rich Chrysanthemum indicum L. Extract has a Beneficial Effect on Metabolic Hypertensive Rats by Inhibiting the Enteric-Origin LPS/TLR4 Pathway

Wang

Shi

et al. 2021

Front. Pharmacol.

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As the number of patients with metabolic hypertension (MH) is increasing, there is an essential require for global measures to prevent and treat MH. Flavonoids such as buddleoside (BUD) from Chrysanthemum indicum L. are the main pharmacological components of cardiovascular activities. Previous studies have suggested that the buddleoside-rich Chrysanthemum indicum L. extract (BUDE) can reduce blood pressure in spontaneously hypertensive rats (SHR). However, its effect on MH and how it works remains to be researched. In this study, it was observed that BUDE could lower blood pressure, improve dyslipidemia, and decrease the level of plasma LPS in MH rats. Moreover, BUDE improved intestinal flora and increased the expression of occludin and claudin-1 in the colon, and improved the pathological injury of the colon. Western bolt and qRT-PCR experiments showed that BUDE could down-regulate TLR4 and MyD88 protein and mRNA expression and inhibit phosphorylation of IKKβ, IκBα and NF-κB p65 in vessels of MH rats. These results showed that BUDE could regulate intestinal flora, improve intestinal barrier function, reduce the production and penetration of LPS, thereby inhibiting the vascular TLR4/MyD88 pathway, improving vascular endothelial function, and ultimately lowering blood pressure in MH rats. This study provides a new mechanism of BUDE against MH by inhibiting the enteric-origin LPS/TLR4 pathway.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Buddleoside-Rich Chrysanthemum indicum L. Extract has a Beneficial Effect on Metabolic Hypertensive Rats by Inhibiting the Enteric-Origin LPS/TLR4 Pathway

Wang

Shi

et al. 2021

Front. Pharmacol.

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Gut microbiota in heart failure and related interventions

Chen

Zhang

2023

iMeta

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Heart failure (HF) is a sophisticated syndrome with structural or functional impairment of ventricular filling or ejection of blood, either causing symptoms and signs or being asymptomatic. HF is a major global health issue affecting about 64.3 million people worldwide. The gut microbiota refers to the complex ecosystem of microorganisms, mainly bacteria, in the gut. Studies have revealed that the gut microbiota is associated with many diseases ranging from neurodegenerative diseases to inflammatory bowel disease and cardiovascular diseases. The gut hypothesis of HF suggests that low cardiac output and systemic circulation congestion would cause insufficient intestinal perfusion, leading to ischemia and intestinal barrier dysfunction. The resulting bacterial translocation would contribute to inflammation. Recent studies have refined the hypothesis that changes of metabolites in the gut microbiota have a close relationship with HF. Thus, the gut microbiota has emerged as a potential therapeutic target for HF due to both its critical role in regulating host physiology and metabolism and its pivotal role in the development of HF. This review article aims to provide an overview of the current understanding of the gut microbiota's involvement in HF, including the introduction of the gut hypothesis of HF, its association with HF progression, the potential mechanisms involved mediated by the gut microbiota metabolites, and the impact of various interventions on the gut microbiota, including dietary interventions, probiotic therapy, fecal microbiota transplantation, antibiotics, and so on. While the gut hypothesis of HF is refined with up‐to‐date knowledge and the gut microbiota presents a promising target for HF therapy, further research is still needed to further understand the underlying mechanisms between gut microbiota and HF, the efficacy of these interventions, and contribute to the health of HF patients.

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Enhancing the solubility and stability of Dendrobium officinale flavonoids through interaction with soybean peptides

Feng,

Liang,

Sui

et al. 2024

Food Measure

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Beneficial effects ofDendrobium officinaleon metabolic hypertensive rats by triggering the enteric-origin SCFA-GPCR43/41 pathway

Abstract: Given the increasing global trend toward unhealthy lifestyles and dietary decisions, such as “over-eating alcohol, and high sugar and fat diets” (ACHSFDs), it is no surprise that metabolic hypertension (MH)...

Cited by 23 publications

References 29 publications

Buddleoside-Rich Chrysanthemum indicum L. Extract has a Beneficial Effect on Metabolic Hypertensive Rats by Inhibiting the Enteric-Origin LPS/TLR4 Pathway

Buddleoside-Rich Chrysanthemum indicum L. Extract has a Beneficial Effect on Metabolic Hypertensive Rats by Inhibiting the Enteric-Origin LPS/TLR4 Pathway

Gut microbiota in heart failure and related interventions

Enhancing the solubility and stability of Dendrobium officinale flavonoids through interaction with soybean peptides

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