Beneficial Effects of Human Umbilical Cord Blood Mononuclear Cells on Persistent Erectile Dysfunction After Treatment of 5-Alpha Reductase Inhibitor in Rats

Öztekin, Çetin Volkan; Yilmaz‐Oral, Didem; Kaya‐Sezginer, Ecem; Kirlangic, Omer Faruk; Özen, Fatma Zeynep; Özdal, Bülent; Topçu, Hasan Onur; Gür, Serap

doi:10.1016/j.jsxm.2021.02.005

Cited by 3 publications

(7 citation statements)

References 52 publications

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“…Pinsky et al [31] displayed no differences in SNP-induced relaxant responses between control and 4week dutasteride treated rats. However, another study showed that relaxation responses to SNP were decreased after 12-week dutasteride treatment [12]. This difference was most probably due to the duration of dutasteride treatment.…”

Section: Resultsmentioning

confidence: 98%

“…In addition, the relaxation response to ACh was lowered in the 8-week dutasteride and 2-week washout groups [19]. Furthermore, the endothelium-dependent relaxation responses were lower after both 8-week and 12-week dutasteride treatment [12]. According to the results, the reduction in the endothelium-dependent relaxation response is likely to be associated with a decreased in free and total T levels following 5-ARIs treatment [12].…”

Section: Resultsmentioning

confidence: 99%

“…Rats were randomly divided into three groups; control (n=10), 10 weeks of dutasteride treatment (n=10), and 6 weeks of dutasteride treatment followed by 4 weeks of washout (n=10). As in previous studies [11,12,19], dutasteride was administered in drinking water (0.5 mg/rat/day). Dutasteride treatment was performed during 6 and 8 weeks in a previous study [19].…”

Section: Animalsmentioning

confidence: 99%

“…[20], polyethylene-50 tubing was inserted into the right crura of the penis and the carotid artery to measure ICP and MAP with a transducer (Statham, Oxnard, CA, USA) and a data acquisition system (Biopac MP 100 System, Santa Barbara, CA, USA). Following the detection of cavernosal nerve (CN), the CN was stimulated (2.5, 5, and 7.5 V, 15 Hz, 1 ms pulse width) with a stainless-steel bipolar-hook stimulating electrode and a square pulse stimulator (Grass Instruments, Quincy, MA) [12]. After intracavernosal injection of sildenafil (0.3 mg/kg) [21][22][23], the measurements were repeated in dutasteride-treated animals.…”

Section: In Vivo Erectile Function Measurementmentioning

confidence: 99%

“…Furthermore, in preclinical data, dutasteride treatment induced ED in rats, even after withdrawal of dutasteride [11,12]. In addition, PDE5Is are the preferred choice, even though there are conflicting results [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

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İntrakavernosal Si̇ldenafi̇li̇n Siçanlarda Dutasterid Tedavi̇si̇ Sonrasi Geli̇şen Erektil Di̇sfonksi̇yon Üzeri̇ne Yararli Etki̇si̇

ORAL

Gür

2022

Ankara Ecz. Fak. Derg.

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Objective: Benign prostatic hyperplasia (BPH) and erectile dysfunction (ED) are the most common illnesses in aged male patients. 5α-reductase inhibitors (5-ARIs) are suggested for the treatment of BPH. Furthermore, the association of 5ARIs with ED has been indicated. This study aimed to investigate the effect of intracavernosal injection of sildenafil on ED in 5ARI treated rats.Material and Method: Sprague-Dawley rats (n=30) were divided into three groups: Control; 10-week dutasteride treatment (0.5 mg/rat/day); and 6-week durasteride treatment followed by a 4-week washout period. In vivo erectile responses were assessed before and after intracavernosal injection of sildenafil (0.3mg/kg/rat). The relaxant and contractile responses of isolated corpus cavernosum were evaluated in in vitro organ bath.Result and Discussion: Prostate weight decreased after 10-week dutasteride treatment. In vivo erectile responses, endothelial and nitrergic relaxation responses were decreased in dutasteride groups. The washout period moderately normalized erectile responses. The intracavernosal injection of sildenafil increased erectile function in treatment groups. Contractile responses were augmented in 10-week dutasteride treated rats. The cessation of the treatment did not alter erectile function as well as endothelial relaxation and nitrergic relaxation. Also, intracavernosal sildenafil caused an improvement in 5ARI treatment-induced ED.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Animalsmentioning

confidence: 99%

Section: In Vivo Erectile Function Measurementmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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İntrakavernosal Si̇ldenafi̇li̇n Siçanlarda Dutasterid Tedavi̇si̇ Sonrasi Geli̇şen Erektil Di̇sfonksi̇yon Üzeri̇ne Yararli Etki̇si̇

ORAL

Gür

2022

Ankara Ecz. Fak. Derg.

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Body fluid-derived stem cells — an untapped stem cell source in genitourinary regeneration

Huang

et al. 2023

Nat Rev Urol

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Effects of Transplantation of Umbilical Cord Blood Mononuclear Cells into the Scrotum on Sexual Function in Elderly Mice

Jiang

Xue

et al. 2023

Regen. Med.

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Aim: This study investigated the effect of allografting umbilical cord blood mononuclear cells (UCBMCs) into the scrotum on sexual function in male elderly mice. Methods: UCBMCs were injected once into the scrotal sheath cavity of elderly mice. Results: The transplanted UCBMCs survived in the scrotal sheath cavity for 1 month. The mice had significantly increased blood testosterone concentrations, cyclic guanosine monophosphate (cGMP) levels and total nitric oxide synthase (T-NOS) activity in the corpus cavernosum and an increase in the number of mouse matings within 30 min (all p = 0.000). Conclusion: Scrotum-implanted UCBMCs improve the sexual function of male elderly mice through testosterone production and the NOS/cGMP pathway, which may provide an innovative transplantation approach for the treatment of erectile dysfunction.

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Beneficial Effects of Human Umbilical Cord Blood Mononuclear Cells on Persistent Erectile Dysfunction After Treatment of 5-Alpha Reductase Inhibitor in Rats

Cited by 3 publications

References 52 publications

İntrakavernosal Si̇ldenafi̇li̇n Siçanlarda Dutasterid Tedavi̇si̇ Sonrasi Geli̇şen Erektil Di̇sfonksi̇yon Üzeri̇ne Yararli Etki̇si̇

İntrakavernosal Si̇ldenafi̇li̇n Siçanlarda Dutasterid Tedavi̇si̇ Sonrasi Geli̇şen Erektil Di̇sfonksi̇yon Üzeri̇ne Yararli Etki̇si̇

Body fluid-derived stem cells — an untapped stem cell source in genitourinary regeneration

Effects of Transplantation of Umbilical Cord Blood Mononuclear Cells into the Scrotum on Sexual Function in Elderly Mice

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