Beneficial effects of hesperidin following cis-diamminedichloroplatinum-induced damage in heart of rats

Oğuztürk, Hakan; Çiftçi, Osman; Çetin, Aslı; Kaya, Kürşat; Disli, Olcay Murat; Turtay, Muhammet Gökhan; Gürbüz, Şükrü; Başak, Neşe

doi:10.4103/1119-3077.173707

Cited by 14 publications

(11 citation statements)

References 1 publication

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“…In rats hesperidin (50 mg/kg/day HP, 14 days, oral gavage) was found to protect rat cardiac function treated by the anticancer drug cisplatin, [95]. With a shorter treatment at a higher dose, hesperidin treatment (200 mg/kg hesperidin/rat, 3 days, oral gavage) attenuates myocardial I/R injury by suppressing myocardial apoptosis, the inflammatory response and oxidative stress via PI3K/Akt pathway activation and HMGB1 (high-mobility group box 1) inhibition in rats [96].…”

Section: Flavanonesmentioning

confidence: 99%

Pure Polyphenols Applications for Cardiac Health and Disease

Santos

Gomes

Oudot

et al. 2018

CPD

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Polyphenols are natural compounds present in fruits and vegetables that can exert beneficial effects on human health and notably, on the cardiovascular system. Some of these compounds showed significant protective activities toward atherosclerosis, hypertension, myocardial infarction, anthracyclin-induced cardiomyopathy, angiogenesis as well as heart failure. Polyphenols can act through systemic effects as well as through modulation of signaling pathways such as redox signaling, inflammation, autophagy and cell death in the heart and vessels. These effects can be mediated by changes in expression level and by post-translational modifications of proteins (e.g. Stat1, CaMKII, Sirtuins, BCL-2 family members, PDEs, TRF2, eNOS and SOD). This non-comprehensive short review aims to summarize recent knowledge on the main pharmacological effects and mechanisms of cardioprotection of pure polyphenols, using different approaches such as cell culture, animal models and human studies.

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Section: Flavanonesmentioning

confidence: 99%

Pure Polyphenols Applications for Cardiac Health and Disease

Santos

Gomes

Oudot

et al. 2018

CPD

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“…Hesperidin (HSP, 3,5,7-trihydroxy-4-methoxy-flavanone-7-rhamnoglucoside), largely isolated from citrus fruits and a member of the flavanone group, exhibits antioxidative, anti-inflammatory [19,20], antihypercholesterolemic [21,22], and antihyperglycemic [23] activities. In recent studies, beneficial effects of hesperidin following toxicity by some compounds have been shown [24][25][26][27][28]. Also, HSP significantly protected against hepatotoxicity induced by lipopolysaccharide [29], cadmium [30], acetaminophen [31], and carbon tetrachloride [32] in rats.…”

Section: Introductionmentioning

confidence: 96%

Exposure to Zinc Oxide Nanoparticles Induces Neurotoxicity and Proinflammatory Response: Amelioration by Hesperidin

Ansar

Abudawood

Hamed

et al. 2016

Biol Trace Elem Res

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Zinc oxide nanoparticles (ZnONPs) are widely used in food packaging and may enter the body directly if exposed. Hereby, in this study, the oral administration was selected as the route of exposure for rats to nanoparticles and the effect of hesperidin (HSP, 100 mg/kg bwt) was evaluated on ZnONP (600 mg/kg bwt)-induced neurotoxicity in rats. ZnONPs were characterized using transmission electron microscopy. Neurotoxicity was observed as seen by elevation in serum inflammatory markers including tumor necrosis factor alpha (TNF-α), interleukin 1 (IL-1β), interleukin-6 (IL-6), C-reactive protein (CRP), and activities of catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione (GSH) content in rat brains. Pretreatment of rats with HSP in ZnONP-treated group elevated activities of antioxidant enzymes. HSP also caused decrease in TNF-α, IL-1β, IL-6, and CRP levels which was higher in the ZnONP-treated group. The results suggest that HSP augments antioxidant defense with anti-inflammatory response against ZnONP-induced neurotoxicity. The increased antioxidant enzymes enhance the antioxidant potential to reduce oxidative stress.

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“…However, there are serious side-effects in addition to its clinical effi cacy (3). Although considered rare (20), cardiotoxicity as a diverse effect of cisplatin therapy has been reported in numerous studies (8,(21)(22)(23)(24).…”

Section: Discussionmentioning

confidence: 99%

The effects of N-acetylcysteine on cisplatin induced cardiotoxicity

Gunturk¹,

Yücel²,

Güntürk³

et al. 2019

BLL

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OBJECTIVES: Recent studies reported that oxidative stress is an important mechanism that contributes to cisplatin induced cardiotoxicity. In the present study, the effects of N-acetylcysteine (NAC), which is an antioxidant, on cisplatin induced cardiotoxicity were investigated in a rat model. METHODS: Thirty two rats were separated into 4 equal groups: Control, NAC-250, CP (cisplatin), CP+NAC. Rats in the experimental groups were treated with a single dose of cisplatin intraperitoneally (ip) (10 mg/kg) and NAC (ip, 250 mg/kg) for 3 consecutive days. At the end of the experiment, cardiotoxicity was determined from plasma CK-MB, LDH, cTnI and cardiac myosin light chain-1 (CMLC-1) levels. In the tissue samples, total oxidant capacity (TOC), total antioxidant capacity (TAC), lipid hydroperoxide (ROOH) and thiol levels were measured. The hearts were also analyzed histopathologically. RESULTS: It was determined that cisplatin increased the tissue TOC, ROOH levels and decreased TAC and thiol levels. NAC administration after cisplatin treatment was observed to have ameliorated histological and functional changes in heart. CONCLUSIONS: In conclusion, the results of this experimental study suggested that oxidative stress had a serious effect on cisplatin cardiotoxicity, and NAC could be used as a therapeutic agent in addition to standard cisplatin treatment protocols (Tab.

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Beneficial effects of hesperidin following cis-diamminedichloroplatinum-induced damage in heart of rats

Abstract: Hesperetin treatment leads to a decrease in oxidative stress, and associated histological damage. The findings of the current study suggest that HP has a protective effect against CP-induced cardiotoxicity.

Cited by 14 publications

References 1 publication

Pure Polyphenols Applications for Cardiac Health and Disease

Pure Polyphenols Applications for Cardiac Health and Disease

Exposure to Zinc Oxide Nanoparticles Induces Neurotoxicity and Proinflammatory Response: Amelioration by Hesperidin

The effects of N-acetylcysteine on cisplatin induced cardiotoxicity

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