Beneficial Effects of Early Treatment of Nevus of Ota With Low-Fluence 1,064-nm Q-Switched Nd

Seo, Hyun-Min; Choi, Chong Won; Kim, Won Serk

doi:10.1097/dss.0000000000000212

Cited by 30 publications

(22 citation statements)

References 17 publications

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“…Prior studies have demonstrated that there is considerable variation in the laser parameters applied in the treatment of pigmentary diseases (usually between two and eight passes) [18][19][20]27]. Our results demonstrate that there is a positive correlation between the number of laser passes and pigmentation improvement.…”

Section: Discussionsupporting

confidence: 66%

Melanogenesis inhibition in mice using a low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser: a pilot study

et al. 2017

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A low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser, or laser toning, has yielded favorable outcomes in various benign pigmented disorders. However, the exact mechanism of action of laser toning has not been fully elucidated. We sought to determine the inhibitory effect of laser toning on melanogenesis and to assess how laser passes influence the outcomes. To produce perceptible pigmentation, nine HRM-2 melanin-possessing hairless mice were treated with ultraviolet (UV) B radiation on the dorsal skin. This was followed by zero, two, four, or six passes of laser toning twice in 2 weeks on each designated quadrant. The spectrophotometric values and pigmentation-related protein expressions were measured. Pigment changes were found in the mice skin using the Fontana-Masson stain for histopathological analysis. Four- and six-pass laser toning significantly improved the lightness compared to that in the unirradiated control (p < 0.002). The Fontana-Masson stain showed that melanin was considerably decreased in laser-irradiated skin. As the number of laser passes increased, the expression of tyrosinase decreased (p < 0.008). The following parameters also decreased in proportion to the number of laser passes: MITF, TRP-1, TRP-2, p-ERK, and p-Akt. In contrast, TGF-β increased in proportion to the number of laser passes. However, the changes in these six proteins were not statistically significant. Our study demonstrates that laser toning improves skin pigmentation with increased number of passes in a dose-dependent manner. This effect is mediated by tyrosinase inhibition.

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Section: Discussionsupporting

confidence: 66%

Melanogenesis inhibition in mice using a low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser: a pilot study

et al. 2017

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“…The possible factors that influence the results of the study were identified in the current literature: eyelid lesions, Tanino's classification, number of treatment sessions, a bilateral nevus, skin phototype, color of the lesion, and age at the first treatment261618. Our results revealed that the frequency of treatments was the key factor, which confirmed that more treatments would result in better outcomes, which is in agreement with other studies216.…”

Section: Discussionsupporting

confidence: 90%

“…There were no statistically significant differences between the cryotherapy-treated group and the others. Previously, topical hydroquinone has also been shown to not have significant benefits6.…”

Section: Resultsmentioning

confidence: 99%

“…The study also included the participants who were involved in the authors' previous reports613. Compared to our previous studies, which chose patients treated with a single laser modality only, patients treated with multiple different laser modalities were included since the aim of our present research was to extend our knowledge of what types of lasers are used in a real practice and to investigate the difference in prognosis between laser systems.…”

Section: Methodsmentioning

confidence: 99%

“…Since the development of laser technology, several lasers have been introduced into the treatment of benign pigmentary lesions. Notably, Q-switched (QS) laser systems have gained popularity in the treatment of NO as they produce less scarring and better outcomes6. Nonetheless, the introduction of various treatment options for NO have made it difficult for dermatologists to choose the best solution in practice.…”

Section: Introductionmentioning

confidence: 99%

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Treatment and Classification of Nevus of Ota: A Seven-Year Review of a Single Institution's Experience

et al. 2017

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BackgroundNevus of Ota (NO) is a relatively common pigmentary disorder in Asians. Tanino's classification is an old but tacit consensus to delineate the disease. Various treatment options have been presented. However, a few studies have been conducted on available laser options and current treatment strategies or the classification of NO.ObjectiveTo investigate current laser options and their effectiveness for the treatment of NO, contributing factors to clinical outcomes, and verification of classification.MethodsA retrospective study of NO was conducted by reviewing medical charts and photographs of sixty-seven patients. Statistical analysis was used to compare excellent and poor outcomes and determine contributing factors.ResultsThe median age of onset was below the age of 1 (interquartile range [IQR], 0~1). Tanino's and PUMCH classification systems failed to classify patients in 24 (35.8%) and 6 (9.0%) of patients, respectively. A 1,064 nm Q-switched Nd:YAG laser without additional lasers was used most frequently in 42 patients (62.7%). The frequency of treatment was 19.0 (IQR, 10.0~23.0) in the cured group defined as subjects showing 95% improvement or above, compared to 10.0 (IQR, 6.25~13.75) in the unattained group defined as subjects showing less than 95% improvement (p=0.001).ConclusionA 1,064 nm Q-switched Nd:YAG laser is a reliable treatment armamentarium, functioning as a single infallible modality as well as a combination treatment modality for NO. Repetitive laser treatments without interruption seems to be the most suitable in clearing NO. The current classification systems of NO are defective. Thus, a new classification should be developed.

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Lasers for Pigmented Lesions

Arora

Falto‐Aizpurua

Rajabi‐Estarabadi

et al. 2019

Pediatric Dermatologic Surgery

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Beneficial Effects of Early Treatment of Nevus of Ota With Low-Fluence 1,064-nm Q-Switched Nd

Abstract: This treatment was clinically effective and safe for early nevus of Ota using a low-fluence Q-switched Nd:YAG laser.

Cited by 30 publications

References 17 publications

Melanogenesis inhibition in mice using a low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser: a pilot study

Melanogenesis inhibition in mice using a low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser: a pilot study

Treatment and Classification of Nevus of Ota: A Seven-Year Review of a Single Institution's Experience

Lasers for Pigmented Lesions

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