Beneficial effects of dietary ascorbic acid supplement on hens subjected to ochratoxin A toxicosis under normal and high ambient temperatures

Haazele, Felix M.; Guenter, W.; Marquardt, R. R.; Frohlich, A. A.

doi:10.4141/cjas93-014

Cited by 26 publications

(16 citation statements)

References 15 publications

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“…At 4 ppm OTA, mortality increases dramatically [134,135]. Haazele et al [139] have demonstrated that vitamin C has beneficial effects in hens exposed to OTA. For the related mycotoxin CIT, which is frequently found as a cocontaminant of food sources [140][141][142], the LD 50 depends on animal strain and sex and on the route of administration.…”

Section: Ota In Human Milkmentioning

confidence: 99%

Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans

Pfohl‐Leszkowicz¹,

Manderville²

2006

Molecular Nutrition Food Res

885

525

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Ochratoxin A (OTA) is a ubiquitous mycotoxin produced by fungi of improperly stored food products. OTA is nephrotoxic and is suspected of being the main etiological agent responsible for human Balkan endemic nephropathy (BEN) and associated urinary tract tumours. Striking similarities between OTA-induced porcine nephropathy in pigs and BEN in humans are observed. International Agency for Research on Cancer (IARC) has classified OTA as a possible human carcinogen (group 2B). Currently, the mode of carcinogenic action by OTA is unknown. OTA is genotoxic following oxidative metabolism. This activity is thought to play a central role in OTA-mediated carcinogenesis and may be divided into direct (covalent DNA adduction) and indirect (oxidative DNA damage) mechanisms of action. Evidence for a direct mode of genotoxicity has been derived from the sensitive 32P-postlabelling assay. OTA facilitates guanine-specific DNA adducts in vitro and in rat and pig kidney orally dosed, one adduct comigrates with a synthetic carbon (C)-bonded C8-dG OTA adduct standard. In this paper, our current understanding of OTA toxicity and carcinogenicity are reviewed. The available evidence suggests that OTA is a genotoxic carcinogen by induction of oxidative DNA lesions coupled with direct DNA adducts via quinone formation. This mechanism of action should be used to establish acceptable intake levels of OTA from human food sources.

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Section: Ota In Human Milkmentioning

confidence: 99%

Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans

Pfohl‐Leszkowicz¹,

Manderville²

2006

Molecular Nutrition Food Res

885

525

View full text Add to dashboard Cite

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“…The ascorbic acid supplementation (300 mg/kg) of laying hen diet that contained 3 ppm OTA has been reported to have a good protective effect against OTA-action and can partially ameliorate OTA-toxicity (including the negative effect of OTA on the eggs production and on the weight of the eggs) [99, 100]. The mechanism of the protective effect is not clear but it is supposed to affect the production of lipid peroxides by OTA and to improve the membrane integrity of cell organelles, which is always affected by OTA-action [22].…”

Section: Methods Of Prophylaxis and Various Preventive Measures Inmentioning

confidence: 99%

“…Also, antipermeability and vasoconstrictive effects of water extract of artichoke could decrease oedema in various internal organs provoked by OTA [18, 27, 29, 30, 94]. The high content of calcium and vitamin C in the steam extract probably has also a protective effect against OTA-toxicity via improving membrane integrity of cell organelles and skeleton-strength of the chicks or via some other ways [27, 29, 94], since some authors reported that ascorbic acid supplementation (300 mg/kg) of laying hen diet that contained OTA (3.0 mg/kg) partially reduced OTA-toxicity [100]. …”

Section: Methods Of Prophylaxis and Various Preventive Measures Inmentioning

confidence: 99%

Complex Etiology, Prophylaxis and Hygiene Control in Mycotoxic Nephropathies in Farm Animals and Humans

Stoev

2008

IJMS

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Abstract:Various etiological factors contributing to the development of mycotoxic nephropathy in farm animals and humans are reviewed. The possible synergistic effect between ochratoxin A (OTA) and other mycotoxins, as penicillic acid (PA) and fumonisin B 1 (FB 1 ), contributing to this nephropathy is also considered and discussed. The most convenient ways of prophylaxis and various preventive measures against OTA contamination of feeds or foods are reviewed. A reference is made concerning the most successful methods of veterinary hygiene control in the slaughterhouses in order to prevent the entering of OTA in commercial channels with a view to human health. The economic efficacy of these prophylactic procedures is also considered. An evaluation of human exposure to OTA is made.Keywords: mycotoxic nephropathy, Balkan endemic nephropathy, ochratoxin A, penicillic acid, fumonisin B 1 , synergism, preventive measures, hygiene control, pathogenesis Abbreviations: MN -mycotoxic nephropathy; MPN -mycotoxic porcine nephropathy; MAN -mycotoxic avian nephropathy; MNFA -mycotoxic nephropathy in farm animals; BEN -Balkan endemic nephropathy; OTA -ochratoxin A; OTα -ochratoxin α; PApenicillic acid; FB 1 -fumonisin B 1Int. J. Mol. Sci. 2008, 9

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“…At the 4 ppm level, mortality rate increases dramatically (Gibson et al , 1990. Haazele et al (1993) demonstrated that vitamin C has bene®cial eOE ects in hens exposed to OTA. The LD 50 of citrinin depends on animal strain and sex and on the route of administration.…”

Section: Summary Of the Toxic Eoe Ects Of Ota And Citrininmentioning

confidence: 99%

Balkan endemic nephropathy and associated urinary tract tumours: a review on aetiological causes and the potential role of mycotoxins

Pfohl‐Leszkowicz

Petkova-Bocharova²,

In³

et al. 2002

Food Additives and Contaminants

310

172

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A series of publications in the 1950s described a kidney disease in Bulgaria, the former Yugoslavia and Romania that became known as Balkan endemic nephropathy (BEN). The disease was qualified by World Health Organisation (WHO) experts as 'progressive and very gradually developing renal failure with insidious onset.... The last stage shows marked fibrosis...'. BEN is characterized by tubular degeneration, interstitial fibrosis and hyalinization of glomeruli accompanied by enzymuria and impaired renal function without nephrotic syndrome. Later, an association between BEN and tumours of the kidney pelvis and ureter was recognized, so that the problem of BEN became not only nephrological, but also oncological. There may also be an association with increased urinary bladder cancer incidence, although many confounding factors may interfere in the analysis of data for this organ. In view of the very intimate association between BEN and the urinary tract tumours (UTT), the term 'endemic uropathy' has been proposed. Several hypothesis concerning the aetiology of these diseases has been investigated, which include: predisposing genes factors, environmental factors (heavy metals, minerals, bacteria, leptospira, viruses, fungal toxins and, most recently, pliocene lignites). This paper reviews the different hypotheses about the aetiology of endemic uropathy and pays particular attention to the role of fungal toxins.

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Beneficial effects of dietary ascorbic acid supplement on hens subjected to ochratoxin A toxicosis under normal and high ambient temperatures

Abstract: The results suggest that some of the detrimental effects of OA in the diet of the laying hen can be counteracted by dietary supplementation of AA.

Cited by 26 publications

References 15 publications

Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans

Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans

Complex Etiology, Prophylaxis and Hygiene Control in Mycotoxic Nephropathies in Farm Animals and Humans

Balkan endemic nephropathy and associated urinary tract tumours: a review on aetiological causes and the potential role of mycotoxins

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