Beneficial Effects of Curcumin on the Wound-healing Process after Tooth Extraction

Abstract

This study evaluated the effects of curcumin, a naturally occurring compound with numerous health-beneficial properties, on the wound-healing process of extraction sockets (soft tissue that surrounded the extracted tooth) in rats. The effects of topically applied curcumin were monitored by tracking changes in myeloperoxidase activity and nitric oxide concentrations in soft tissue homogenates 3 and 7 days following surgery. Additionally, pathohistological examination of tissue sections was used to reveal the effects of curcumin on the course of wound healing on a microscopic level. Compared to the untreated control, topically administered curcumin statistically significantly decreased soft-tissue myeloperoxidase activity and nitric oxide concentrations after both 3 and 7 days of application. Microscopic analysis showed a reduced inflammatory infiltrate (subjectively and morphometrically estimated as the number of polymorphonuclear cells/100 μm 2) and an increased collagen deposition in rats treated with curcumin. The obtained results point to the great potential of curcumin in the acceleration of tooth extraction wound-healing processes partially through the reduction of the inflammatory response and increase in collagen deposition. Thus, these results significantly contribute to the previously suggested application of curcumin in the skin wound treatment by potentially broadening its usage in the treatment of mucosal wounds.

Evaluation of Curcumin Effect on Wound Healing in Rat Model

“…This finding agrees with Mitic et al who noticed that collagen deposition started earlier (at day 7 of his study) in the curcumin-treated group of rats' tooth extraction sites. 43 He also noticed that curcumin treatment significantly improved the alignment, thickness, and architectural regularity of the deposited collagen fascicles compared to other studied groups. Qian et al also proved that topical Curcumin improved burn-wound healing by increasing collagen deposition from the 4 th to the 12 th day of their experiment on excision wounds in rats.…”

Curcumin nanoliposomes mitigate wound tissue inflammatory response caused by tooth extraction

“…Curcumin (CUR) is a compound originating from turmeric plant (Anamika, 2012) which is known to possess numerous beneficial properties such as anticancer, anti-nociceptive, anti-inflammatory, anti aging and wound healing (Mitić et al, 2017). The wound healing potential of CUR is believed to be based on its effect on the inflammatory process (Mohanty, Das, Sahoo, 2012), as well as on the production and deposition of collagen fibers (Mitić et al, 2017). Additionally, CUR is known to enhance epithelial regeneration and to cause an increase in fibroblast proliferation and vascular density (Akbik et al, 2014).…”

“…Tissue examinations were performed using a lightmicroscope (Olympus BX43, Olympus Corporation, Tokyo, Japan) and digital photographs were obtained using the imaging system (Olympus cell Sens platform standard, Olympus Corporation,Tokyo, Japan) at 200x magnification. The extent of tissue inflammation, the amount of granulation tissue formation and the degree of angiogenesis was scored as follows: 0 -parameter expression is poor; 1 -the evaluated parameter expression is moderate; 2parameter expression is strong (Mitić et al, 2017).…”

Development of a Multifunctional Bioerodible Nanocomposite Containing Metronidazole and Curcumin to Apply on L-PRF Clot to Promote Tissue Regeneration in Dentistry

“…This latter is also widely applied in dentistry [ 22 , 23 ]. After teeth extraction, the topic administration of CUR can decrease soft tissue inflammation, protect the wound from bacterial infections, increase collagen deposition and stimulate cell proliferation, improving tissue regeneration [ 24 ]. Due to its lipophilic nature and physicochemical instability [ 25 ], CUR needs to be included in a pharmaceutical formulation to be available in aqueous environments.…”