Beneficial Effects of Combined Treatment With Rosiglitazone and Exercise on Cardiovascular Risk Factors in Patients With Type 2 Diabetes

Kadoglou, Nikolaos P.E.; Iliadis, Fotios; Liapis, Christos D.; Perrea, Despina; Angelopoulou, Nickoletta; Alevizos, Miltiadis

doi:10.2337/dc07-0341

Cited by 26 publications

(22 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study demonstrates for the first time that the K174G/C genotype is a significant and independent predictor of reduced IL-6 serum concentrations after a long-term exercise training program. This suggests that previously reported beneficial anti-inflammatory effects of physical training in patients with T2D (18,19) are at least modified by genetic factors. The strong genotype, exercise response association for circulating IL-6, might also provide an explanation for the heterogeneous results on whether and in which direction IL-6 serum concentrations are changed by long-term physical exercise (16,18,19,22).…”

Section: Discussionmentioning

confidence: 58%

“…However, in the rosiglitazone treatment group, there was only a trend for reduced IL-6 serum concentrations in our study. Since reduced circulating IL-6 levels after rosiglitazone treatment have recently been reported (19), the small number of subjects in our rosiglitazone group might be the reason for an insufficient statistical power to detect significant improved IL-6 serum concentrations upon rosiglitazone treatment in our study. Moreover, subjects included in the present study had only IGT and did not have diabetes and, therefore, we cannot exclude possible effects of rosiglitazone on IL-6 and hsCRP in diabetic patients.…”

Section: Discussionmentioning

confidence: 86%

“…Kadoglou et al have recently demonstrated that a 16-week aerobic exercise training program significantly reduces IL-6 serum concentrations in patients with T2D (18). Moreover, combined exercise training with rosiglitazone treatment resulted in a greater decrease in circulating IL-6 than exercise alone (19). It was further demonstrated that rosiglitazone treatment reduces both IL-6 serum concentrations in patients with T2D (20) and IL-6 mRNA expression in human s.c. adipose tissue (21).…”

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Long-term exercise training decreases interleukin-6 (IL-6) serum levels in subjects with impaired glucose tolerance: effect of the −174G/C variant in IL-6 gene

Oberbach¹,

Lehmann²,

Kirsch³

et al. 2008

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Exercise training has been shown to have anti-inflammatory effects in patients with type 2 diabetes. Changes in interleukin-6 (IL-6) serum concentrations in response to training could contribute to these beneficial effects. However, there are heterogeneous data on whether circulating IL-6 is altered by exercise training. We therefore hypothesize that genetic factors modify the individual changes in IL-6 levels after long-term training. Research design and methods:The K174G/C variant in the IL-6 gene was genotyped in 60 subjects with impaired glucose tolerance. For a 12-month interventional study, patients were randomized into three groups: a control group (nZ16) was compared with one group, which underwent a standardized training program (nZ24) and another group, which was treated with 4 mg rosiglitazone once daily (nZ20). At baseline, after 1, 6, and 12 months, we measured anthropometric parameters and serum concentration of IL-6 and, at baseline and after 12 months, we determined glucose tolerance and fitness level. Results: Only in subjects carrying the SNP K174C allele did long-term exercise training result in significantly reduced IL-6 serum concentrations. Multivariate linear regression analysis identified the IL-6 genotype as a significant predictor of changes in IL-6 serum concentrations independent of age, gender and improvement in body mass index, hemoglobin (Hb)A 1c , and fitness level in response to training. Conclusions: Genetic variants in the IL-6 gene significantly modify changes in IL-6 serum concentrations in response to long-term exercise training programs. Our data suggest that genetic factors are important determinants for the individual response to anti-inflammatory effects of exercise training. 159 129-136 European Journal of Endocrinology

show abstract

Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Long-term exercise training decreases interleukin-6 (IL-6) serum levels in subjects with impaired glucose tolerance: effect of the −174G/C variant in IL-6 gene

Oberbach¹,

Lehmann²,

Kirsch³

et al. 2008

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Steppan et al also reported an interesting observation that circulating resistin levels are decreased by the antidiabetic drug, rosiglitazone [7]. Later, Kadoglou et al demonstrated that rosiglitazone treatment in diabetes increases cardiorespiratory fitness and favorably modulates serum adiponectin, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-2 levels -markers of remodeling in HF [19].…”

Section: Physiology and Pathophysiologymentioning

confidence: 94%

Serum Resistin: Physiology, Pathophysiology and Implications for Heart Failure

et al. 2010

View full text Add to dashboard Cite

Resistin, a 12.5-kDa polypeptide, has been associated with both insulin resistance and inflammation in animal models. Although initially discovered in the adipocytes, it has subsequently been found in other tissues. In humans, controversy still exists regarding the role of resistin but serum resistin concentration has been correlated with risk factors for coronary heart disease, renal dysfunction and outcomes among stroke patients. Both inflammation and insulin resistance are associated with the development of incident heart failure, with worse outcomes among those with prevalent cardiomyopathy. Therefore, it is interesting to note that recent literature suggests a significant relationship between serum resistin concentrations and heart failure. In this article, we discuss the physiology, pathophysiology, and the direct and indirect role of resistin in determining heart failure risk and worse outcomes among these patients. Some of the salient points reviewed include the possible association of resistin with hyperglycemia and substrate metabolism, inflammation through TNF-alpha and direct cardiac effects.

show abstract

“…201 Patients were considered as having diabetes if receiving oral antidiabetic medication, insulin treatment, having a fasting plasma glucose level of 126 mg per deciliter (7.0 mmol per liter) or greater, or having an elevated hemoglobin A1c (glycosylated hemoglobin) of ≥ 7%. 202 This information was selfreported and corroborated from patients' medical records.…”

Section: Diabetes Mellitusmentioning

confidence: 99%

Impact of a Comprehensive Nutrition and Lifestyle Education Intervention on Body Weight and Health-Related Outcomes in Morbidly-Obese Hispanic-Americans Following Laparoscopic Roux-En Y Gastric Bypass

Nijamkin¹

View full text Add to dashboard Cite

Beneficial Effects of Combined Treatment With Rosiglitazone and Exercise on Cardiovascular Risk Factors in Patients With Type 2 Diabetes

Cited by 26 publications

References 20 publications

Long-term exercise training decreases interleukin-6 (IL-6) serum levels in subjects with impaired glucose tolerance: effect of the −174G/C variant in IL-6 gene

Long-term exercise training decreases interleukin-6 (IL-6) serum levels in subjects with impaired glucose tolerance: effect of the −174G/C variant in IL-6 gene

Serum Resistin: Physiology, Pathophysiology and Implications for Heart Failure

Impact of a Comprehensive Nutrition and Lifestyle Education Intervention on Body Weight and Health-Related Outcomes in Morbidly-Obese Hispanic-Americans Following Laparoscopic Roux-En Y Gastric Bypass

Contact Info

Product

Resources

About