Beneficial effects of coffee in non-alcoholic fatty liver disease: a narrative review

Calabrò, A.; Procopio, Anna; Primerano, Francesco; Larussa, Tiziana; Luzza, Francesco; Renzo, Laura Di; Lorenzo, Antonino De; Gualtieri, Paola; Abenavoli, Ludovico

doi:10.20517/2394-5079.2020.63

Cited by 7 publications

(12 citation statements)

References 46 publications

(54 reference statements)

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“…There is a certain negative correlation between coffee consumption and the occurrence and progression of chronic liver diseases, including fatty liver and liver fibrosis. Some epidemiological studies found that the risk of NAFLD in patients who drank coffee was significantly lower than that in patients who did not and a significantly decreased risk of liver fibrosis among NAFLD patients who drank coffee ( Bambha et al, 2015 ; Wijarnpreecha et al, 2017 ; Calabro et al, 2020 ). Vitaglione et alfound that coffee supplementation prevented HFD-induced NAFLD in mice by reducing hepatic fat deposition and modulating pathways of the gut-liver axis and gut microbiota ( Vitaglione et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Chlorogenic Acid Improves NAFLD by Regulating gut Microbiota and GLP-1

Shi

Zheng

et al. 2021

Front. Pharmacol.

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Our previous studies have shown that chlorogenic acid (CGA) could significantly improve acute and chronic liver injury through antioxidant and anti-inflammatory activities. However, its effect on non-alcoholic fatty liver disease (NAFLD) are not entirely clear. This study aims to explore the effect of CGA on NAFLD induced by high-fat diet (HFD) and whether it regulates the gut microbiota and Glucagon-like peptide-1 (GLP-1). NAFLD mice were established by HFD and treated with or without CGA. Serum transaminase, fasting blood glucose (FBG), blood lipids, insulin, GLP-1 and lipopolysaccharide (LPS) were detected. Liver histology was evaluated with Hematoxylin-eosin staining. Toll like receptor 4 (TLR4) signaling pathway was analyzed with western blot and inflammatory cytokines were detected with real-time PCR. The content of gut microbiota were determined with real-time PCR of the bacterial 16S rRNA gene. Expressions of intestine tight junctional protein were examined with immunohistochemistry. CGA could alleviate HFD-induced hepatic steatosis and inflammation, reduce serum transaminase, FBG and blood lipids, increase insulin sensitivity. CGA also could reverse HFD-induced activation of TLR4 signaling pathway and expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in liver. Meanwhile, CGA increased the content of Bifidobacterium and reduced the content of Escherichia coli in feces. Furthermore, CGA could increase the expression of tight junction proteins Occludin and zonula occludens-1 (ZO-1) in intestinal tissue. Moreover, CGA could the level of LPS and increased the level of GLP-1 in portal vein. These results indicated that CGA protected against HFD-induced hepatic steatosis and inflammation probably through its anti-inflammatory effects associated with regulation of gut microbiota and an increase of GLP-1 secretion and thus could be used as a potential drug for prevention and treatment of NAFLD.

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Section: Discussionmentioning

confidence: 99%

Chlorogenic Acid Improves NAFLD by Regulating gut Microbiota and GLP-1

Shi

Zheng

et al. 2021

Front. Pharmacol.

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“…Coffee and its bioactive compounds were widely investigated [ 152 , 153 ]. The in vitro study showed that caffeic acid could ameliorate hepatic steatosis and decrease endoplasmic reticulum stress by increasing autophagy in AML12 cells [ 121 ].…”

Section: Mechanisms Of Plant-based Foods and Their Bioactive Compomentioning

confidence: 99%

“…Collectively, green tea and its bioactive compounds (like EGCG) could alleviate AFLD by improving ethanol metabolism, lipid metabolism, oxidative stress, inflammation, and necrosis (Table 1), with increasing the activities of ADH and ALDH and the phosphorylation of ACC, reducing the Coffee and its bioactive compounds were widely investigated [152,153]. The in vitro study showed that caffeic acid could ameliorate hepatic steatosis and decrease endoplasmic reticulum stress by increasing autophagy in AML12 cells [121].…”

Section: Mechanisms Of Teas and Their Bioactive Compounds On Afldmentioning

confidence: 99%

Plant‐Based Foods and Their Bioactive Compounds on Fatty Liver Disease: Effects, Mechanisms, and Clinical Application

Gan

Shang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Fatty liver disease (FLD), including nonalcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD), is a serious chronic metabolic disease that affects a wide range of people. Lipid accumulation accompanied by oxidative stress and inflammation in the liver is the most important pathogenesis of FLD. The plant-based, high-fiber, and low-fat diet has been recommended to manage FLD for a long time. This review discusses the current state of the art into the effects, mechanisms, and clinical application of plant-based foods in NAFLD and AFLD, with highlighting related molecular mechanisms. Epidemiological evidence revealed that the consumption of several plant-based foods was beneficial to alleviating FLD. Further experimental studies found out that fruits, spices, teas, coffee, and other plants, as well as their bioactive compounds, such as resveratrol, anthocyanin, curcumin, and tea polyphenols, could alleviate FLD by ameliorating hepatic steatosis, oxidative stress, inflammation, gut dysbiosis, and apoptosis, as well as regulating autophagy and ethanol metabolism. More importantly, clinical trials confirmed the beneficial effects of plant-based foods on patients with fatty liver. However, several issues need to be further studied especially the safety and effective doses of plant-based foods and their bioactive compounds. Overall, certain plant-based foods are promising natural sources of bioactive compounds to prevent and alleviate fatty liver disease.

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“…Meta-analyses have reported a prevalence ranging between 25 and 32% ( Younossi et al, 2016 ; Park et al, 2021 ). The incidence of NAFLD has tended to increase over time due to behavioral changes leading to unhealthy lifestyles in the global population ( European Association for the Study of the Liver, European Association for the Study of Diabetes, European Association for the Study of Obesity, 2016 ; Li et al, 2019 ; Calabrò et al, 2020 ). The latest meta-analyses showed that the incidence of NAFLD was approximately 42.8–50.9 per 1,000 person-years ( Li et al, 2019 ; Park et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Behavioral modification, weight reduction, and drug therapies are hoped to be effective treatments for NAFLD. Despite the fact that there is no approved pharmacological treatment for NAFLD and non-biopsy-proven patients ( European Association for the Study of the Liver, European Association for the Study of Diabetes, European Association for the Study of Obesity, 2016 ; Chalasani et al, 2018 ; Leoni et al, 2018 ), behavioral changes that lead to weight reduction, fat- and carbohydrate-diet adjustment, exercise, proper sleep, and coffee consumption have caught the attention of researchers ( European Association for the Study of the Liver, European Association for the Study of Diabetes, European Association for the Study of Obesity ; Chalasani et al, 2018 ; Leoni et al, 2018 ; Calabrò et al, 2020 ). Numerous studies have shown that coffee consumption has many positive effects on the liver, such as reducing the risk of fatty liver disease, lowering the severity of hepatic steatosis, and slowing the progression of fibrosis ( Molloy et al, 2012 ; Zelber-Sagi et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Coffee Consumption and Non-alcoholic Fatty Liver Disease: An Umbrella Review and a Systematic Review and Meta-analysis

et al. 2021

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Background: The effects of coffee consumption on hepatic outcomes are controversial. This study investigated the associations between coffee consumption and the incidence of non-alcoholic fatty liver disease (NAFLD) in the general population and the reduction of liver fibrosis among patients with NAFLD.Methods: The study consisted of two parts: an umbrella review and a systematic review and meta-analysis (SRMA). The searches for each part were performed separately using PubMed, EMBASE, Cochrane, Scopus, and CINAHL databases. All articles published up to September 2021 were reviewed. To be eligible, studies for the umbrella review were required to report outcomes that compared the risks of NAFLD in the general population and/or liver fibrosis in patients with NAFLD who did and did not drink coffee. Our SRMA included primary studies reporting the effects of coffee consumption on NAFLD-related outcomes. The outcomes were pooled using a random-effects model and reported in both qualitative and quantitative terms (pooled risk ratio, odds ratio, and weighted mean difference).Results: We identified four published SRMAs during the umbrella review. Most studies showed that individuals in the general population who regularly drank coffee were significantly associated with a lower NAFLD incidence than those who did not. Our SRMA included nine studies on the effects of coffee consumption on NAFLD incidence. Pooled data from 147,875 subjects showed that coffee consumption was not associated with a lower NAFLD incidence in the general population. The between-study heterogeneity was high (I2, 72–85%). Interestingly, among patients with NAFLD (5 studies; n = 3,752), coffee consumption was significantly associated with a reduction in liver fibrosis (odds ratio, 0.67; 95% CI, 0.55 to 0.80; I2, 3%). There were no differences in the coffee consumption of the general population and of those with NAFLD (4 studies; n = 19,482) or by patients with no/mild liver fibrosis and those with significant fibrosis (4 studies; n = 3,331).Conclusions: There are contrasting results on the effects of coffee on NAFLD prevention in the general population. Benefits of coffee consumption on liver fibrosis were seen among patients with NAFLD.Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021226607, identifier CRD42021226607

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Beneficial effects of coffee in non-alcoholic fatty liver disease: a narrative review

Cited by 7 publications

References 46 publications

Chlorogenic Acid Improves NAFLD by Regulating gut Microbiota and GLP-1

Chlorogenic Acid Improves NAFLD by Regulating gut Microbiota and GLP-1

Plant‐Based Foods and Their Bioactive Compounds on Fatty Liver Disease: Effects, Mechanisms, and Clinical Application

Coffee Consumption and Non-alcoholic Fatty Liver Disease: An Umbrella Review and a Systematic Review and Meta-analysis

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