Beneficial effects of cocoa on lipid peroxidation and inflammatory markers in type 2 diabetic patients and investigation of probable interactions of cocoa active ingredients with prostaglandin synthase-2 (PTGS-2/COX-2) using virtual analysis

Parsaeyan, Nayereh; Mozaffari‐Khosravi, Hassan; Absalan, Abdorrahim; Mozayan, Mohammad Reza

doi:10.1186/2251-6581-13-30

Cited by 39 publications

(29 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The accumulating results of previous studies showed that cocoa consumption declines the lipid oxidation product formation such as MDA. In agreement with our results, in T2DM patients receiving 10 grams cocoa powder and 10 grams milk powder twice daily for 6 weeks, a significant inhibition of lipid peroxidation has been reported; but cocoa administration did not influence serum MDA levels in T2DM patients [37] . A large body of evidence suggests that such effects may be due to flavonoids contents of Cocoa [37] .…”

Section: Acknowledgmentsupporting

confidence: 82%

“…In agreement with our results, in T2DM patients receiving 10 grams cocoa powder and 10 grams milk powder twice daily for 6 weeks, a significant inhibition of lipid peroxidation has been reported; but cocoa administration did not influence serum MDA levels in T2DM patients [37] . A large body of evidence suggests that such effects may be due to flavonoids contents of Cocoa [37] . Polyphenol content in cocoa exerts an antioxidant effect that scavenge reactive oxygen species, chelate Fe 2+ and Cu + , inhibit enzymes, and up-regulate antioxidant defenses [38] .…”

Section: Acknowledgmentsupporting

confidence: 82%

See 1 more Smart Citation

The Effects of Dark Chocolate Consumption on Lipid Profile, Fasting Blood Sugar, Liver Enzymes, Inflammation, and Antioxidant Status in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized, Placebo-Controlled, Pilot study

Alavinejad

Farsi²,

Rezazadeh³

et al. 2015

Journal of Gastroenterology and Hepatology Research

View full text Add to dashboard Cite

BACKGROUND: Nonalcoholic fatty liver disease (NAFLD)is an important health problem worldwide and despite the rising prevalence, there is currently no satisfying therapeutic strategy. Dark chocolate (DC) is a food rich in phenolic antioxidants, which may exert favorable and modifying effects on lipid profile, insulin resistance, oxidative stress, and metabolic effects. This study aims to investigate the possible effects of DC consumption on the lipid profile, fasting blood sugar (FBS), liver transaminases (ALT, and AST), inflammatory, and antioxidant status among NAFLD patients. METHODS: In this double-blind, placebo-controlled trial, 42 patients with NAFLD were randomly allocated to 2 groups: the treatment group (n=21) whom received 30 gr dark chocolate (83%) daily and the control group (n=21), for a 12 weeks period. RESULTS: During the intervention period, taking 30 gr DC (83%) daily resulted in a significant decrease in AST (P=0.012), body weight (P=0.027), and BMI (P=0.042) in the treatment group. In addition, patients who received DC had considerable changes in serum HDL (P=0.044). However, no significant changes occurred in serum levels of ALT, hs-CRP, anthropometric measures (WC, HC, and WHR), and grades of NAFLD in both groups (P>0.05). CONCLUSION: DC consumption can decrease the level of AST in patients with NAFLD and could be a potential therapeutic approach. We recommend more investigation about potential therapeutic effects of dark chocolate to be further clarified.

show abstract

Section: Acknowledgmentsupporting

confidence: 82%

Section: Acknowledgmentsupporting

confidence: 82%

The Effects of Dark Chocolate Consumption on Lipid Profile, Fasting Blood Sugar, Liver Enzymes, Inflammation, and Antioxidant Status in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized, Placebo-Controlled, Pilot study

Alavinejad

Farsi²,

Rezazadeh³

et al. 2015

Journal of Gastroenterology and Hepatology Research

View full text Add to dashboard Cite

show abstract

“…More recently, the study by Parsaeyan et al. assessed the effect of cocoa power on the lipid profile and peroxidation in addition to the inflammatory markers in DMT2 patients. A total of one hundred people with DMT2 were randomly divided into two groups of 50 individuals.…”

Section: Antidiabetic Actions Of Cocoa Flavonoidsmentioning

confidence: 99%

Antidiabetic actions of cocoa flavanols

Martín

Goya

Ramos

2016

Molecular Nutrition Food Res

103

View full text Add to dashboard Cite

Prevention of diabetes mellitus type 2 (DMT2) through the diet is receiving a growing interest and cocoa because of its polyphenolic compounds, mainly flavanols, has become an important potential chemopreventive natural agent. Cocoa and its main flavanols might contribute to prevent or delay diabetes mellitus type 2 by modulating insulin secretion in β-pancreatic cells and targeting insulin-sensitive tissues because of their insulin-like activity or through the regulation of key proteins of the insulin signaling route. Among other actions, cocoa flavanols have been proved to enhance glucose uptake through the promotion of glucose transport, to repress glucose production, or to improve lipid metabolism. Nevertheless, the molecular mechanisms of action involved in these effects are not fully understood and many points remain to be clarified. This review provides insights into the molecular machinery of the chemopreventive activity of cocoa and its flavanols by compiling cell culture and animal models studies, as well as evidence from human interventional trials.

show abstract

“…More recently, EC-rich cocoa mediated modulation of oxidative stress regulators in skeletal muscle of heart failure and T2D patients (Ramírez-Sánchez, I. et al, 2013). Additionally, administration of a fibre-rich cocoa product to moderately hypercholesterolemic humans evoked a hypoglycaemic effect (Sarriá, B. et al, 2014) and consumption of cocoa powder for six weeks lowered blood cholesterol, low density lipoprotein (LDL)-cholesterol and inflammation markers in patients with T2D (Parsaeyan, N. et al, 2014). Finally, acute cocoa supplementation increased postprandial HDL-cholesterol and insulin in obese adults with T2D after consumption of a high-fat breakfast (Basu, A. et al, 2015).…”

Section: 3-cocoamentioning

confidence: 99%

Protective effects of tea, red wine and cocoa in diabetes. Evidences from human studies

Martín

Goya

Ramos

2017

Food and Chemical Toxicology

View full text Add to dashboard Cite

Prevention of diabetes through the diet has recently received an increasing interest, and polyphenolic compounds, such as flavanols, have become important potential chemopreventive natural agents due to their proved benefits on health, with low toxicity and cost. Tea, red wine and cocoa are good sources of flavanols and these highly consumed foods might contribute to prevent diabetes. In this regard, there is increasing evidence for a protective effect of tea, red wine and cocoa consumption against this disorder. This review summarizes the available epidemiological and interventional human studies providing evidence for and against this effect. Overall observational data suggest a benefit, but results are still equivocal and likely confounded by lifestyle and background dietary factors. The weight of data indicate favourable effects on diabetes risk factors for tea, red wine and cocoa intake, and a number of plausible mechanisms have been elucidated in human studies. However, despite the growing evidence it remains uncertain whether tea, red wine and cocoa consumption should be recommended to the general population or to patients as a strategy to reduce the risk of diabetes.

show abstract

Beneficial effects of cocoa on lipid peroxidation and inflammatory markers in type 2 diabetic patients and investigation of probable interactions of cocoa active ingredients with prostaglandin synthase-2 (PTGS-2/COX-2) using virtual analysis

Cited by 39 publications

References 34 publications

The Effects of Dark Chocolate Consumption on Lipid Profile, Fasting Blood Sugar, Liver Enzymes, Inflammation, and Antioxidant Status in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized, Placebo-Controlled, Pilot study

The Effects of Dark Chocolate Consumption on Lipid Profile, Fasting Blood Sugar, Liver Enzymes, Inflammation, and Antioxidant Status in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized, Placebo-Controlled, Pilot study

Antidiabetic actions of cocoa flavanols

Protective effects of tea, red wine and cocoa in diabetes. Evidences from human studies

Contact Info

Product

Resources

About