Beneficial effects of cilostazol in a patient with recurrent ventricular fibrillation associated with early repolarization syndrome

Iguchi, Kenta; Noda, Takashi; Kamakura, Shiro; Shimizu, Wataru

doi:10.1016/j.hrthm.2012.11.001

Cited by 38 publications

(30 citation statements)

References 15 publications

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“…115-118 Chronic oral pharmacological therapy using quinidine, 119, 120 bepridil, 117 denopamine, 115, 121 and cilostazol 115, 117, 121-125 is reported to suppress the development of VT/VF in both ERS and BrS secondary to inhibition of I to, augmentation of I Ca , or both. 3, 122, 126 …”

Section: Similarities and Difference Between Brs And Ersmentioning

confidence: 99%

“…122 PDE inhibitors are known to activate I Ca secondary to an increase in cAMP. 121, 344, 351-355 The augmentation of I Ca is thought to prevent arrhythmias associated with JWS by reversing the repolarization defects and restoring electrical homogeneity across the ventricular wall secondary to restoration of the epicardial AP dome in both BrS 347 and ERS.…”

Section: Pharmacologic Approach To Therapymentioning

confidence: 99%

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J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge

et al. 2016

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Section: Similarities and Difference Between Brs And Ersmentioning

confidence: 99%

Section: Pharmacologic Approach To Therapymentioning

confidence: 99%

J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge

et al. 2016

Self Cite

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“…160 PDE inhibitors are known to activate I Ca secondary to an increase in cAMP. 132, 148, 161-165 The augmentation of I Ca is thought to prevent arrhythmias associated with the J wave syndromes by reversing the repolarization defects and restoring electrical homogeneity across the ventricular wall secondary to restoration of the epicardial action potential dome in both BrS 152 and ERS.…”

Section: Introductionmentioning

confidence: 99%

J-wave syndromes: Brugada and early repolarization syndromes

2015

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A prominent J wave is encountered in a number of life-threatening cardiac arrhythmia syndromes, including the Brugada (BrS) and early repolarization (ERS) syndromes. BrS and ERS differ with respect to the magnitude and lead location of abnormal J waves and are thought to represent a continuous spectrum of phenotypic expression termed J wave syndromes. Despite two decades of intensive research, risk stratification and the approach to therapy of these two inherited cardiac arrhythmia syndromes are still undergoing rapid evolution. Our objective in this review is to provide an integrated synopsis of the clinical characteristics, risk stratifiers, as well as the molecular, ionic, cellular and genetic mechanisms underlying these two fascinating syndromes that have captured the interest and attention of the cardiology community in recent years.

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“…Quinidine is effective in suppressing VF storms and recurrences, but its availability is limited (7,8). Cilostazol has been shown to be effective in preventing VF recurrence in BrS and IVF (9,10); however, the long-term effect of these drugs on J-waves and VF recurrence is poorly understood in BrS.…”

Section: Introductionmentioning

confidence: 99%

Long-term Pharmacological Therapy of Brugada Syndrome: Is J-wave Attenuation a Marker of Drug Efficacy?

et al. 2014

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We herein describe two patients with Brugada syndrome in whom J-waves were successfully modified by drugs. Case 1 was a 54-year-old man who presented with repeated ventricular fibrillations (VF) and J-point elevation in the right precordial and lateral leads. After administration of cilostazol (200 mg/d), J-waves disappeared and coved-type ST-segment elevation changed to a saddleback-type for 25 months. Case 2 was a 31-year-old man who presented with a VF storm and J-point elevation in the lateral leads. After administration of quinidine (300 mg/d), J-waves and coved-type ST-segment elevation disappeared for 20 months. Jwave disappearance and coved-type ST-segment elevation were followed by VF suppression, probably due to transient outward potassium current (Ito) suppression.

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Beneficial effects of cilostazol in a patient with recurrent ventricular fibrillation associated with early repolarization syndrome

Cited by 38 publications

References 15 publications

J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge

J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge

J-wave syndromes: Brugada and early repolarization syndromes

Long-term Pharmacological Therapy of Brugada Syndrome: Is J-wave Attenuation a Marker of Drug Efficacy?

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