Beneficial effects of Chinese herbs in the treatment of fatty liver diseases

Panyod, Suraphan; Sheen, Lee‐Yan

doi:10.1016/j.jtcme.2020.02.008

Cited by 14 publications

(9 citation statements)

References 88 publications

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“…In recent years, TCM and its extracts have been considered a new potential source of therapeutic drugs for preventing and treating fatty liver disease [80]. According to modern TCM theory, type 2 diabetes belongs to the category of diabetes.…”

Section: Tcm Syndrome Types Of T2dm With Nafldmentioning

confidence: 99%

Main Risk Factors of Type 2 Diabetes Mellitus with Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma

Fan

Ran

et al. 2021

Journal of Oncology

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Type 2 diabetes mellitus (T2DM) with nonalcoholic fatty liver disease (NAFLD) is a pathological metabolic disease characterized by high ketone lipid based on abnormal lipid metabolism. Compared with patients with single T2DM or NAFLD, T2DM complicated with NAFLD has more complicated pathogenic factors and pathological processes. Hepatocellular carcinoma (HCC), the leading malignancy arising from cirrhosis, is the second most lethal cancer globally. The purpose of this study was to clarify the main risk factors of T2DM with NAFLD and HCC. There are many challenges in the diagnosis and treatment of T2DM patients with NAFLD and HCC. The current gold standard is to adjust treatment strategy, optimize metabolic control, and improve liver phenotype. It is necessary to identify further the risk factors driving the progression of T2DM with NAFLD and HCC and evaluate new therapeutic targets, in addition to exploring the syndromic forms of T2DM combined with NAFLD and providing a theoretical basis for early prevention, diagnosis, and treatment of the disease using traditional Chinese medicine (TCM).

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Section: Tcm Syndrome Types Of T2dm With Nafldmentioning

confidence: 99%

Main Risk Factors of Type 2 Diabetes Mellitus with Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma

Fan

Ran

et al. 2021

Journal of Oncology

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“…Therefore, finding effective treatment with minimal side effects is essential. Medicinal plants and their constituents have multiple protective and therapeutic effects, so they are widely used to treat diseases and their complex complications, including metabolic diseases such as NAFLD (Francini‐Pesenti, Spinella, & Calò, 2019; Panyod & Sheen, 2020). However, medicinal plants and natural compounds as complementary and alternative therapeutics and conventional restorative therapy reduce the dose of chemical drugs with high side effects and increase their effectiveness (Čabarkapa et al, 2016; Rafieian‐Kopaei, 2012).…”

Section: Introductionmentioning

confidence: 99%

The effects of co‐administration of artichoke leaf extract supplementation with metformin and vitamin E in patients with nonalcoholic fatty liver disease: A randomized clinical trial

Majnooni

Ataee

Bahrami

et al. 2021

Phytotherapy Research

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Medicinal plants are widely used as a complementary therapy to treat complex diseases, such as nonalcoholic fatty liver disease (NAFLD). Therefore, this study was done to investigate the effect of co-administration of artichoke leaf extract supplement (ALES) with conventional medicines on patients with NAFLD. The clinical trial was based on patients randomly divided into three groups involving metforminvitamin E (ME), metformin-ALES (MA), and vitamin E-ALES (EA). The effectiveness of treatment in the treated groups was evaluated using liver ultrasonography and biochemical markers. After 12 weeks of treatment, the results showed that the rate of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) was significantly reduced within all the study groups (p < .05). Liver ultrasonographic findings revealed that the rate of fat accumulation in liver of patients was decreased significantly within all the study groups and it was increased in the subjects with grade 0 fatty liver (without fat accumulation) in the MA and EA groups by 23.3 and 17.2%, respectively. In summary, the results of the present study showed that the concomitant use of ALES with metformin and vitamin E can have beneficial effects on amelioration of complications in patients with NAFLD. However, larger-scale clinical trial studies are required in this regard.

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“…31,32,33 Recently, allicin was reported to exhibit a modulatory effect on the gut microbiota and reduced hepatic steatosis. 34,35 Additionally, our previous pilot study showed that allicin supplementation shaped the gut microbiota composition and reduced TMAO production by the gut microbiota in mice subjected to moderate carnitine consumption (0.02 %carnitine). 36 However, the role of raw garlic with allicin in improving cardiovascular phenotypes via gut microbiota modulation has not been fully elucidated.…”

Section: Introductionmentioning

confidence: 98%

Atherosclerosis Amelioration by Allicin in Raw Garlic through Gut Microbiota and Trimethylamine-N-Oxide Modulation

Sheen

Panyod

et al. 2021

Preprint

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Cardiovascular disease (CVD) is strongly associated with the gut microbiota and its metabolites, including trimethylamine-N-oxide (TMAO) formed from ʟ-carnitine. Raw garlic juice, with allicin as its primary compound, has been shown to powerfully impact the gut microbiota. This study validated the benefits of raw garlic juice against CVD risk via modulation of the gut microbiota and its metabolites. Allicin supplementation significantly decreased serum TMAO in ʟ-carnitine-fed C57BL/6J mice. It also reduced aortic lesions and altered the fecal microbiota in carnitine-induced, atherosclerosis-prone, apolipoprotein E-deficient mice. In human subjects exhibiting high TMAO production, raw garlic juice intake for a week reduced TMAO formation, improved gut microbial diversity, and increased the relative abundances of beneficial bacteria. In in vitro study, raw garlic juice inhibited γ-butyrobetaine (γBB) and trimethylamine (TMA) production by the gut microbiota. Thus, raw garlic juice can potentially prevent cardiovascular disease by decreasing TMAO production through gut microbiota modulation.

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Beneficial effects of Chinese herbs in the treatment of fatty liver diseases

Cited by 14 publications

References 88 publications

Main Risk Factors of Type 2 Diabetes Mellitus with Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma

Main Risk Factors of Type 2 Diabetes Mellitus with Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma

The effects of co‐administration of artichoke leaf extract supplementation with metformin and vitamin E in patients with nonalcoholic fatty liver disease: A randomized clinical trial

Atherosclerosis Amelioration by Allicin in Raw Garlic through Gut Microbiota and Trimethylamine-N-Oxide Modulation

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