Beneficial effects of certain phosphodiesterase inhibitors on diabetes mellitus in rats

Sayed, Mostafa El Sayed El; Eid, Nehad; Kamel, Ahmed S.

doi:10.1016/j.bfopcu.2014.06.001

Cited by 5 publications

(5 citation statements)

References 26 publications

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“…The results of the current study of SC in diabetic rats showed that after six weeks of treatment, the group of diabetic rats treated with SC had significantly lower blood glucose levels and significantly higher serum insulin concentrations than the diabetic rats that did not receive SC. These findings agree with earlier studies, demonstrating the part sildenafil plays in reducing blood glucose concentration at higher doses [4,12,13]. Enhanced insulin action in rats has been associated with chronic PDE-5 inhibition [4].…”

Section: Resultssupporting

confidence: 92%

“…El Sayed et al (2014) found that giving diabetic rats SC at doses ranging from 5-20 mg/kg BW) decreased their blood glucose level and raised their serum insulin to an extent proportional to the SC dose given. They suggested that when cGMP hydrolysis is inhibited, cGMP-dependent protein kinase G is activated, which results in the phosphorylation of hormone-sensitive lipase, thereby boosting free fatty acids and energy expenditure [12]. This is also in line with research by Taha et al (2021), who reported a significant (48%) reduction in serum blood glucose and a significant rise (17%) in serum insulin in diabetic albino rats treated with SC (10 mg/kg BW) for four weeks compared to their counterparts [13].…”

Section: Resultsmentioning

confidence: 99%

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The Potential Effect of Sildenafil Citrate on Some Hematological and Biochemical Parameters in Hyperglycemic Rats

Hussein¹

2022

Pharmacophore

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Sildenafil citrate (SC) is a phosphodiesterase type-5 inhibitor, which acts to increase cyclic guanosine monophosphate (cGMP). This study aims to assess the effects of Sildenafil citrate (SC) on glycemic control and hematological parameters of diabetic rats induced with streptozotocin (STZ). Fifty male Wistar rats were divided into four groups (n=10/non-diabetic group; n=15/diabetic group): i. control (I), ii. SC-treated control (II), iii. diabetic (III), and iv. SC-treated diabetic (IV). Diabetes was induced by an intraperitoneal injection of STZ (50 mg/kg). SC (20 mg/kg body weight) was administered orally for six weeks. Blood specimens were taken to measure levels of serum glucose (FBG), insulin, glycated hemoglobin (HbA1c), aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, creatinine, prothrombin time (PT), partial thromboplastin time (aPTT), fibrinogen, protein C, and protein S. Levels of FBG, HbA1c, AST, ALT, urea, creatinine, and fibrinogen were significantly elevated in the rats with diabetes compared to the controls. Conversely, insulin, aPTT, protein C and S were significantly lower in the diabetic groups. No significant difference was seen in the PT of control and diabetic rats. No effect was found in the administration of SC on healthy control rats. Upon administration of SC to the diabetic rats, these parameters returned to normal (P<0.05). SC was found to improve glycemic control as well as microcirculatory perfusions in diabetic rats, warranting its consideration as a way to lessen diabetic complications.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

The Potential Effect of Sildenafil Citrate on Some Hematological and Biochemical Parameters in Hyperglycemic Rats

Hussein¹

2022

Pharmacophore

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“…According to the current data, multiple methods for identification of Eimeria species are utilized in field diagnosis. In the current study, 9 of 15 samples tested positive for coccidian oocysts, yielding an overall prevalence of 60% which is in agreement with different reports from various countries (75% by Ramesh et al ( 42 ) from Chennai (India), 67.58% by Gül et al ( 43 ) from Van City (Turkey), 61.36% by El-Sayed ( 44 ) from Sharkia Governorate (Egypt), 59.6% by Aleksandra and Pilarczyk ( 6 ) from Pomerania province (German), 58.2% by Elseify et al ( 45 ) from Qena province (Egypt), 56.2% by Joseph et al ( 46 ) from Maiduguri Metropolis Borno State (Nigeria), and 52% by Hui et al ( 47 ) from Shanghai (China)). It has been reported that young and growing pigeons lack acquired immunity to coccidian infections and outbreaks can occur under conditions of poor hygiene.…”

Section: Discussionsupporting

confidence: 91%

Morphology, morphometry, and phylogeny of the protozoan parasite, Eimeria labbeana-like (Apicomplexa, Eimeriidae), infecting Columba livia domestica

Albasyouni,

Abdel-Gaber,

Al Quraishy

et al. 2024

Front. Vet. Sci.

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IntroductionEimeria spp. are intracellular protozoan parasites of the phylum Apicomplexa causing economic losses to various wild and domestic animals. An eimerian species infecting Columba livia domestica was identified in this study.MethodsA total of 15 faecal samples were examined by floatation technique, a prevalence rate of 60% was reported. Eimerian oocysts were sporulated in 2.5% potassium dichromate solution then identified using morphological and molecular (DNA amplification of the 18S rRNA and ITS-1 genes) diagnostic techniques.ResultsSporulated oocysts were identified as Eimeria labbeana-like, after morphometry with typical bi-layered wall with spherical to subspherical oocysts morphology. A polar granule is present, but no micropyle or oocyst residuum. Sporocysts are elongated ovoidal with stieda body. Sporocyst residuum with many granules and sporozoites with refractile bodies and nucleus. Both 18S rRNA and ITS-1 sequences have been deposited in GenBank database. DNA sequences from the partial 18S rRNA generated from the oocysts were found to be related to eimerian and isosporan parasites found in domestic pigeons. For the first time, ITS-1 sequences for E. labbeana-like were provided.ConclusionThe necessity of using molecular techniques to describe pigeon intestinal coccidian parasites in conjunction with traditional morphology-based tools was emphasized in this work in order to understand the biology of such parasites.

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“…Stress growth, meaning the growing of algae under certain conditions, occurs in both nutritional and environmental conditions. A nutritional condition is mainly to reduce the nitrogen in the growth medium to be 0.0 or 10% [28], and the other is to increase the salinity and iron ions [29][30][31]. When N. oculata was incubated under 2.0% NaCl, 25% F2, and 10% bagasse extract, noticeable growth differences were observed.…”

Section: Effect Of Induction On N Oculata Growthmentioning

confidence: 99%

Biomass Fatty Acid Profile and Fuel Property Prediction of Bagasse Waste Grown Nannochloropsis oculata

et al. 2022

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The Chrythophyta alga Nannochloropsis oculata was mixotrophically grown in artificial media enriched with acid-prehydrolyzed bagasse waste as a source of organic carbon. The used growth medium was composed of F2 nutrients, sea salt (22.0 g L−1), and bagasse extract dissolved in sterile tap water. All of the determined growth parameters resulted in their maximums, as the alga was fed with 25% F2 growth medium enriched with 10% bagasse extract, while bagasse-extract-free medium engaged the total chlorophyll and carotenes at the expense of dry weight accumulation during the vegetative growth period. On the contrary, the dry weight under induction growth slightly differed among the different employed treatments; however, all the treatments surpassed the control one, and variation was obviously found in the cases of chlorophyll and carotene. A slight increase in oil content (6.19–11.89%) was observed, as the vegetative cells were grown under induction conditions. The fatty acids ranged between C16 and C20, and the proportions of SFA and MUFA increased from a sum of 63.57% to 88.31%, while the PUFA, including linoleic acid, α-linolenic acid, and arachidonic acid, declined from 36.3 to 11.69%. Concerning the fuel properties, the induction-produced oil surpassed the vegetative one.

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Beneficial effects of certain phosphodiesterase inhibitors on diabetes mellitus in rats

Cited by 5 publications

References 26 publications

The Potential Effect of Sildenafil Citrate on Some Hematological and Biochemical Parameters in Hyperglycemic Rats

The Potential Effect of Sildenafil Citrate on Some Hematological and Biochemical Parameters in Hyperglycemic Rats

Morphology, morphometry, and phylogeny of the protozoan parasite, Eimeria labbeana-like (Apicomplexa, Eimeriidae), infecting Columba livia domestica

Biomass Fatty Acid Profile and Fuel Property Prediction of Bagasse Waste Grown Nannochloropsis oculata

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