Beneficial effects of cerebellar rTMS stimulation on a patient with spinocerebellar ataxia type 6

Ge, Di; Su, Xiaolin; Zhou, Zhifan; Che, Sixuan; Zeng, Silin; Guo, Yi

doi:10.1016/j.brs.2018.12.225

Cited by 12 publications

(12 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Each session was applied daily for 5 days a week for 20 weeks. They observed a significant improvement in posture and gait, kinetic functions, and speech, whereas no improvement in oculomotor movements was identified [63].…”

Section: Clinical Studiesmentioning

confidence: 96%

Non-Invasive Cerebellar Stimulation in Neurodegenerative Ataxia: A Literature Review

Benussi

Pascual‐Leone

Borroni

2020

IJMS

View full text Add to dashboard Cite

Cerebellar ataxias are a heterogenous group of degenerative disorders for which we currently lack effective and disease-modifying interventions. The field of non-invasive brain stimulation has made much progress in the development of specific stimulation protocols to modulate cerebellar excitability and try to restore the physiological activity of the cerebellum in patients with ataxia. In light of limited evidence-based pharmacologic and non-pharmacologic treatment options for patients with ataxia, several different non-invasive brain stimulation protocols have emerged, particularly employing repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) techniques. In this review, we summarize the most relevant rTMS and tDCS therapeutic trials and discuss their implications in the care of patients with degenerative ataxias.

show abstract

Section: Clinical Studiesmentioning

confidence: 96%

Non-Invasive Cerebellar Stimulation in Neurodegenerative Ataxia: A Literature Review

Benussi

Pascual‐Leone

Borroni

2020

IJMS

View full text Add to dashboard Cite

show abstract

“…Particularly, the present study is the rst to examine the e cacy of iTBS treatment and the comparative in uence of low-frequency and high-frequency rTMS in improving the clinical symptoms of SCA3. So far, only three studies have reported the effect of high-frequency rTMS on degenerative cerebellar ataxia, including one study exploring the effect of 10 Hz rTMS in a patient with SCA6, and two studies that investigated the effect of iTBS in 50 patients with MSA, and 6 SCA38 patients respectively [14][15][16] . Another study reported the effect of 5Hz rTMS on cerebellar ataxia in six patients with multiple system atrophy 17 .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of cerebellar transcranial magnetic stimulation in spinocerebellar ataxia type 3: A randomized controlled trial

Shi

Zou

Chen

et al. 2023

Preprint

View full text Add to dashboard Cite

Spinocerebellar ataxia type 3 (SCA3) is the most common subtype of SCA without effective treatment. This study aimed to evaluate the comparative efficacy of low-frequency repetitive transcranial magnetic stimulation (rTMS) and intermittent Theta Burst Stimulation (iTBS) in a larger cohort of SCA3 patients. One hundred and twenty patients with SCA3 were randomly selected to receive 1Hz rTMS, iTBS or sham. All patients were assessed at baseline and after all sessions. Primary outcomes included the Scale for the Assessment and Rating of Ataxia (SARA) and the International Cooperative Ataxia Rating Scale (ICARS). Secondary outcomes included 10-meter walking test (10MWT), nine-hole peg test (9-HPT), and PATA Rate Test (PRT). This study revealed that 1Hz rTMS and iTBS outperformed sham in reducing the SARA and ICARS scores in SCA3 patients, but with no difference between 1Hz rTMS and iTBS. Furthermore, iTBS decreased 9-HPT scores when using a non-dominant hand. Additionally, we found that symptom severity variance of patients did not influence the effect of rTMS on the clinical impression. No severe adverse events were recorded in this study. The study concluded that 1Hz rTMS and iTBS interventions targeting the cerebellum are effective and safe in patients with SCA3.

show abstract

“…SARA score decreased from 14 points at baseline to 6 points after the intervention and to 2.5 points after eighteen months (without additional therapy). Improvements were observed in the ICARS domains of posture and gait, limb coordination, and speech, but not in oculomotor movements [ 133 ]. In the second case report, TMS was applied over both M1 and the cerebellum five days a week for two consecutive weeks, with a repetition of the protocol after two weeks.…”

Section: Cerebellar Tms In Hereditary Ataxiasmentioning

confidence: 99%

The Therapeutic Potential of Non-Invasive and Invasive Cerebellar Stimulation Techniques in Hereditary Ataxias

Benussi

Batsikadze

França

et al. 2023

Cells

View full text Add to dashboard Cite

The degenerative ataxias comprise a heterogeneous group of inherited and acquired disorders that are characterized by a progressive cerebellar syndrome, frequently in combination with one or more extracerebellar signs. Specific disease-modifying interventions are currently not available for many of these rare conditions, which underscores the necessity of finding effective symptomatic therapies. During the past five to ten years, an increasing number of randomized controlled trials have been conducted examining the potential of different non-invasive brain stimulation techniques to induce symptomatic improvement. In addition, a few smaller studies have explored deep brain stimulation (DBS) of the dentate nucleus as an invasive means to directly modulate cerebellar output, thereby aiming to alleviate ataxia severity. In this paper, we comprehensively review the clinical and neurophysiological effects of transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation (rTMS), and dentate nucleus DBS in patients with hereditary ataxias, as well as the presumed underlying mechanisms at the cellular and network level and perspectives for future research.

show abstract

Beneficial effects of cerebellar rTMS stimulation on a patient with spinocerebellar ataxia type 6

Cited by 12 publications

References 6 publications

Non-Invasive Cerebellar Stimulation in Neurodegenerative Ataxia: A Literature Review

Non-Invasive Cerebellar Stimulation in Neurodegenerative Ataxia: A Literature Review

Efficacy of cerebellar transcranial magnetic stimulation in spinocerebellar ataxia type 3: A randomized controlled trial

The Therapeutic Potential of Non-Invasive and Invasive Cerebellar Stimulation Techniques in Hereditary Ataxias

Contact Info

Product

Resources

About