Beneficial effects of celery (Apium graveolens) on metabolic syndrome: A review of the existing evidences

Abstract

The metabolic syndrome (MetS) is a cluster of multiple conditions that includes hypertension, dyslipidemia, abdominal obesity, and hyperglycemia disorders. Most studies revealed that the MetS is accompanied with an increased risk for cardiovascular disease, Type 2 diabetes mellitus, and insulin resistance. It can be said that, in treating or preventing the MetS and its components, lifestyle adjustment and weight loss have a vital role. According to various studies, among natural compounds, celery (Apium graveolens) is one of the most important sources of phytochemicals such as phenolic acids, flavones, flavonols, and antioxidants such as vitamin C, beta‐carotene (Provitamin A), and manganese. These antioxidants have a role in decreasing the oxidative damage. The phytochemicals in celery decrease the activity of proinflammatory cytokines and prevent inflammation. Also, flavonoids in celery suppress cardiovascular inflammation. Oxidative stress and inflammation in the blood stream are the main risk factors in increasing cardiovascular disease, especially atherosclerosis. Celery phthalides leads to expanding of smooth muscle in the blood vessels and lower blood pressure. As a result, the most active ingredients in celery (A. graveolens (have shown hypolipidemic, antidiabetic, and hypotensive properties. In this review, we summarized the mechanisms underlying the protective effects of celery components on insulin action, glucose, lipid metabolism, and blood pressure.

Safety Evaluation and Biochemical Efficacy of Celery Seed Extract (Apium Graveolens) Capsules in Hypertensive Patients: A Randomized, Triple-blind, Placebo-Controlled, Cross-Over, Clinical Trial

“…Compared to other parts of the plant, celery seeds have more effective ingredients (Moghadam et al, 2013;Popović et al, 2006). The celery seeds contain various active ingredients, including luteolin, d-limonene, phthalides, apigenin, hesperitin, rosmarinic acid, linalool, and quercetrin (Hedayati et al, 2019;Priecina and Karklina, 2014;Tashakori-Sabzevar, Razavi, et al, 2016). The pharmacological mechanisms of these active ingredients are discovered and reported in previous studies (Anjos et al, 2013;Dianat et al, 2015;Su et al, 2015;Triyono et al, 2018).…”

Type 2 Diabetes Mellitus in Latinx Populations in the United States: A Culturally Relevant Literature Review

“…Common herbal remedies for the treatment of T2DM among Latinx individuals include prickly pear cactus, aloe vera, celery, and chayote [ 69 ]. The efficacy of these herbal remedies has been shown, but with uncertain implications for clinical practice; for example, while prickly pear cactus has been shown to reduce serum glucose and insulin levels, likely due to its high fiber contents and hypoglycemic properties [ 70 ], aloe vera has shown to slightly improve glycemic control, but with great heterogeneity across studies [ 71 ], substances like celery have mostly shown promise for hyperglycemia control in rat models [ 72 ]. One study found that while nearly 70% of Latinx patients used herbal remedies, a majority reported that they did not disclose their use of herbal remedies to providers [ 69 ].…”

Safety Evaluation and Biochemical Efficacy of Celery Seed Extract (Apium Graveolens) Capsules in Hypertensive Patients: A Randomized, Triple-blind, Placebo-Controlled, Cross-Over, Clinical Trial

“…Compared to other parts of the plant, celery seeds have more effective ingredients [12,13]. The celery seeds contain various active ingredients, including luteolin, d-limonene, phthalides, apigenin, hesperitin, rosmarinic acid, linalool, and quercetrin [14][15][16]. The pharmacological mechanisms of these active ingredients are discovered and reported in previous studies [17][18][19][20].…”