Beneficial effects of caffeic acid phenethyl ester (CAPE) on the ischaemia-reperfusion injury in rat skin flaps

Aydoğan, Hakan; Gürlek, Ali; Parlakpınar, Hakan; Aşkar, İbrahim; Karabulut, Aysun Bay; Aydoğan, Nilay; Fariz, Alpay; Acet, Ahmet

doi:10.1016/j.bjps.2006.01.030

Cited by 59 publications

(36 citation statements)

References 32 publications

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“…16,39) CGA, a natural phenolic compound found in human diet, has been reported to exhibit potent antioxidant and antiinflammatory activities. [18][19][20][21]40) Hypoglycemic effects of CGA has been shown in diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

“…Caffeic acid phenethyl ester, which is an ester form of CGA metabolites, was shown to exhibit beneficial effects on the survival of dorsal skin flaps and protective effects against I/R injury by surgical skin flap. 16,42) Additionally, caffeic acid phenethyl ester partly accelerates cutaneous full-thickness wound healing by its antioxidant and ROS-scavenging capabilities. 43) These findings suggest that the effect of CGA in our study may be a result of CGA action itself and/ or the action of its metabolites, such as caffeic acid.…”

Section: Discussionmentioning

confidence: 99%

“…7,[9][10][11][12][13][14] Various natural antioxidants significantly improve flap survival. 11,[15][16][17] Strategic therapeutic approaches with antioxidants have been used to reduce the oxidative stress effects of diabetes. 5) These findings suggest that antioxidants may modulate the oxidative stress response in flap tissue, especially in diabetic flap surgery.…”

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confidence: 99%

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Effects of Systemic Chlorogenic Acid on Random-Pattern Dorsal Skin Flap Survival in Diabetic Rats

Bağdaş

Etoz

Inan

et al. 2014

Biological & Pharmaceutical Bulletin

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There has been considerable interest in understanding the effects of antioxidants in flap survival during diabetes. Previous studies showed that chlorogenic acid (CGA) exhibits potent antioxidant effects. We aimed to determine the effects of systemic CGA treatment on skin flap survival in an experimental random-pattern dorsal skin flap model in diabetic rats. Twenty-eight male Wistar rats were divided into four groups: phosphate buffered saline (PBS)-treated or CGA-treated nondiabetic rats, PBS-treated or CGA-treated diabetic rats. Diabetes was induced by streptozotocin (45 mg/kg). Caudally based bipedicled dorsal skin flaps were elevated. CGA (100 mg/kg) or PBS (mL/kg; as vehicle) was administered intraperitoneally once daily. On postoperative day 7, flap survival, regional blood perfusion and microangiography were evaluated. The malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD) and nitric oxide (NO) levels were evaluated from the flap tissue. Capillary density and vascular endothelial growth factor (VEGF) expression were assessed. Harmful effects of diabetes on flap survival were observed. CGA attenuated these effects and allowed greater survival and blood perfusion. CGA decreased MDA and NO levels and increased GSH and SOD levels. CGA elevated capillary density and VEGF expression. This study showed that peripherally administered CGA significantly improved flap survival in diabetic and nondiabetic rats.Key words antioxidant; chlorogenic acid; diabetes; dorsal skin flap; flap survival; oxidative stress Skin flaps are widely used in the repair of local tissue loss and the reconstruction of several tissue defects. Flap necrosis is frequently observed in flap tissues in the postoperative period and is an unwanted effect of healing. Many factors are known to play a role in this major complication such as ischemia, inadequate blood flow and disturbed venous drainage.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Effects of Systemic Chlorogenic Acid on Random-Pattern Dorsal Skin Flap Survival in Diabetic Rats

Bağdaş

Etoz

Inan

et al. 2014

Biological & Pharmaceutical Bulletin

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“…Previously, we investigated the impacts of these agents in the different events induced by I/R such as skin flap injury [26], liver injury related to MI/R [27], myocardial infarct size and oxidative changes [6] and MI/R induced apoptotic cell death [7]. Ischemiadepended injury includes free radical formation and neutrophil activation [26].…”

Section: Free Oxygen Radicalsmentioning

confidence: 99%

Pathophysiology of Myocardial Ischemia Reperfusion Injury: A Review

Parlakpınar

Orum²,

Sağır³

2013

Med-Science

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“…The massive influx of neutrophils results in tissue injury beyond that caused by I/R alone. Numerous substances have been examined in an attempt to attenuate I/R injury in skin or muscle, such as hydrogen sulfide (Henderson et al, 2010), caffeic acid phenethyl ester (Aydogan et al, 2007), and vitamin E (Arato et al, 2010). Most of these studies have shown positive results but lacked independent large-scale follow-up reports.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap

Zhao

Wang

Qin

et al. 2013

J. Zhejiang Univ. Sci. B

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Abstract:Objective: Skin damage induced by ischemia/reperfusion (I/R) is a multifactorial process that often occurs in plastic surgery. The mechanisms of I/R injury include hypoxia, inflammation, and oxidative damage. Hydrogen gas has been reported to alleviate cerebral I/R injury by acting as a free radical scavenger. Here, we assessed the protective effect of hydrogen-rich saline (HRS) on skin flap I/R injury. Methods: Abdominal skin flaps of rats were elevated and ischemia was induced for 3 h; subsequently, HRS or physiological saline was administered intraperitoneally 10 min before reperfusion. On postoperative Day 5, flap survival, blood perfusion, the accumulation of reactive oxygen species (ROS), and levels of cytokines were evaluated. Histological examinations were performed to assess inflammatory cell infiltration. Results: Skin flap survival and blood flow perfusion were improved by HRS relative to the controls. The production of malondialdehyde (MDA), an indicator of lipid peroxidation, was markedly reduced. A multiplex cytokine assay revealed that HRS reduced the elevation in the levels of inflammatory cytokines, chemokines and growth factors, with the exception of RANTES (regulated on activation, normal T-cell expressed and secreted) growth factor. HRS treatment also reduced inflammatory cell infiltration induced by I/R injury. Conclusions: Our findings suggest that HRS mitigates I/R injury by decreasing inflammation and, therefore, has the potential for application as a therapy for improving skin flap survival.

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Beneficial effects of caffeic acid phenethyl ester (CAPE) on the ischaemia-reperfusion injury in rat skin flaps

Cited by 59 publications

References 32 publications

Effects of Systemic Chlorogenic Acid on Random-Pattern Dorsal Skin Flap Survival in Diabetic Rats

Effects of Systemic Chlorogenic Acid on Random-Pattern Dorsal Skin Flap Survival in Diabetic Rats

Pathophysiology of Myocardial Ischemia Reperfusion Injury: A Review

Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap

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