Beneficial effects of banana leaves (Musa x paradisiaca) on glucose homeostasis: Multiple sites of action

Kappel, Virgínia Demarchi; Cazarolli, Luisa Helena; Pereira, Danielle Fontana; Postal, Bárbara Graziela; Madoglio, Fernanda Angélica; Buss, Ziliani da Silva; Reginatto, Flávio Henrique; Silva, Fátima R M B

doi:10.1590/s0102-695x2013005000062

Cited by 36 publications

(26 citation statements)

References 27 publications

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“…Moreover, the complications of DM (i.e., increased oxidative damage and of specific markers) can also be observed. Currently, although the effect of bananas in preventing hyperglycemia has already been reported (8,9), its effects on oxidative damage from type 1 DM remains unknown (28). Protein oxidation was significantly higher in the liver of the diabetic rats fed a standard diet (commercial feed) than in the liver of rats without DM maintained with the standard diet (p < 0.05).…”

Section: Discussionmentioning

confidence: 97%

“…Studies have shown the importance of the banana for DM control (8,9); however, to the best of the authors' knowledge, there are no reports on the effects of green banana pasta on DM complications. Among the possible metabolites related to DM control, the flavonoids are the most cited, and their antioxidant effects can be implicated on the modulation of oxidative damage in several inflammatory diseases (8,9).…”

Section: Iabetes Mellitus (Dm) Is a Group Of Endocrinementioning

confidence: 99%

“…The positive effects of a healthy diet on the risk of diseases are widely recognized; thus, functional foods (i.e., foods that show a health benefit beyond basic nutrition, providing health promotion or disease prevention) are considered important factors in the prevention and control of DM (6)(7)(8)(9).…”

Section: Iabetes Mellitus (Dm) Is a Group Of Endocrinementioning

confidence: 99%

“…Musa x paradisíaca L. (Musaceae family), commonly known as the banana, originated in Southeast Asia, and currently, over 1,000 varieties of bananas are grown in tropical and subtropical regions around the world (9,10). Bananas are the fourth most important food in trade worldwide (11).…”

Section: Iabetes Mellitus (Dm) Is a Group Of Endocrinementioning

confidence: 99%

“…Among the possible metabolites related to DM control, the flavonoids are the most cited, and their antioxidant effects can be implicated on the modulation of oxidative damage in several inflammatory diseases (8,9).…”

Section: Iabetes Mellitus (Dm) Is a Group Of Endocrinementioning

confidence: 99%

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Green banana pasta diet prevents oxidative damage in liver and kidney and improves biochemical parameters in type 1 diabetic rats

Silva

Cerdeira

Brito

et al. 2016

Arch. Endocrinol. Metab.

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Objective: In this study, the effects of a green banana pasta diet on the oxidative damage from type 1 diabetes mellitus (DM) were investigated. Materials and methods: Formulations containing 25 (F25), 50 (F50), and 75% (F75) of green banana pasta were prepared and included in a 12-week diet of Wistar rats with alloxan-induced type 1 DM. The effects of these formulations in preventing oxidative damage in kidneys and liver homogenates of rats were evaluated using the TBARS assay (lipid peroxidation in liver) and the DNPH assay (protein oxidation in liver and kidneys). Furthermore, the effects of the formulations on the fasting glycemia, fructosamine levels, renal function (creatinine), liver function (enzymes aspartate aminotransferase [AST] and alanine aminotransferase [ALT]), and lipid profile (total cholesterol and fractions) in the serum of rats were evaluated in addition to the evaluation of the centesimal composition and microbiological analysis of the produced green banana pasta. Results: An F75 diet prevented hyperglycemia in diabetic rats (p < 0.05) compared to the diabetic rats fed a standard diet (commercial feed). Notably, the protein oxidation in both the liver and kidneys were prevented in diabetic rats on the F50 or F75 diets compared to the control group, whereas the lipid peroxidation was only prevented in the liver (p < 0.05). Moreover, all formulations prevented an increase in the amount of triglycerides in the serum of the rats. The F25 and F50 diet prevented the increase of cholesterol, and the F75-based diet of ALT and fructosamine (p < 0.05) supported the anti-hyperglycemic effects and the protection against oxidative damage. Conclusion: The green banana pasta (F75) diet showed great potential for preventing complications associated with diabetes. Arch Endocrinol Metab. 2016;60(4):355-66

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Section: Discussionmentioning

confidence: 97%

Section: Iabetes Mellitus (Dm) Is a Group Of Endocrinementioning

confidence: 99%

Section: Iabetes Mellitus (Dm) Is a Group Of Endocrinementioning

confidence: 99%

Section: Iabetes Mellitus (Dm) Is a Group Of Endocrinementioning

confidence: 99%

Section: Iabetes Mellitus (Dm) Is a Group Of Endocrinementioning

confidence: 99%

See 3 more Smart Citations

Green banana pasta diet prevents oxidative damage in liver and kidney and improves biochemical parameters in type 1 diabetic rats

Silva

Cerdeira

Brito

et al. 2016

Arch. Endocrinol. Metab.

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Musa paradisiaca L. leaf and fruit peel hydroethanolic extracts improved the lipid profile, glycemic index and oxidative stress in nicotinamide/streptozotocin‐induced diabetic rats

Ahmed

El‐Twab

Al‐Muzafar

et al. 2020

Veterinary Medicine & Sci

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This study aimed to assess antihyperlipidemic, cardiac and antioxidant effects as well as mode of actions of Musa paradisiaca (M. paradisiaca) leaf and fruit peel hydroethanolic extracts in nicotinamide (NA)/streptozotocin (STZ)‐induced diabetic rats. Experimental diabetes mellitus was induced by a single intraperitoneal injection of STZ (60 mg/kg body weight), 15 min after intraperitoneal injection of NA (120 mg/kg body weight). NA/STZ‐induced diabetic rats were orally supplemented with M. paradisiaca leaf and fruit peel hydroethanolic extracts in a dose of 100 mg/kg body weight/day for 28 days. The treatment of NA/STZ‐induced diabetic rats with M. paradisiaca leaf and fruit peel extracts significantly decreased the elevated fasting and post‐prandial serum glucose, total cholesterol, triglycerides, LDL‐cholesterol and vLDL‐cholesterol levels and significantly increased the lowered serum insulin level, liver glycogen content, serum HDL‐cholesterol level, homeostasis model assessment‐insulin resistance (HOMA‐IS) and HOMA‐β cell function. The elevated cardiovascular risk indices in diabetic rats were significantly improved due to treatment with M. paradisiaca extracts. Concomitant with the increase in liver glycogen content, the glucose‐6‐phosphatase activity significantly decreased reflecting the decrease in hepatic glucose output. The heart function was potentially ameliorated as manifested by decrease in the elevated serum creatine kinase‐MB, lactate dehydrogenase and aspartate aminotransferase activities after treatments of diabetic rats with M. paradisiaca extracts. The elevated liver lipid peroxidation and the decline in liver glutathione content and superoxide dismutase, glutathione peroxidase and glutathione‐S‐transferase activities were significantly reversed by treatments. Thus, it can be concluded that M. paradisiaca leaf and fruit peel hydroethanolic extracts may have antihyperlipidemic and cardioprotective potentials in NA/STZ‐induced diabetic rats. These effects may be mediated via improvements in the glycemic state, β‐cell function, tissue insulin sensitivity, and antioxidant defense mechanism.

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Banana and Plantains: Improvement, Nutrition, and Health

Ghag¹,

Ganapathi²

2018

Reference Series in Phytochemistry

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Beneficial effects of banana leaves (Musa x paradisiaca) on glucose homeostasis: Multiple sites of action

Cited by 36 publications

References 27 publications

Green banana pasta diet prevents oxidative damage in liver and kidney and improves biochemical parameters in type 1 diabetic rats

Green banana pasta diet prevents oxidative damage in liver and kidney and improves biochemical parameters in type 1 diabetic rats

Musa paradisiaca L. leaf and fruit peel hydroethanolic extracts improved the lipid profile, glycemic index and oxidative stress in nicotinamide/streptozotocin‐induced diabetic rats

Banana and Plantains: Improvement, Nutrition, and Health

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