Beneficial effects of a red wine polyphenol extract on high-fat diet-induced metabolic syndrome in rats

Auberval, N.; Dal, Stéphanie; Maillard, Élisa; Bietiger, W.; Péronet, C.; Pinget, M.; Schini‐Kerth, Valérie B.; Sigrist, S.

doi:10.1007/s00394-016-1192-2

Cited by 16 publications

(15 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a previous study carried out by our group, we showed that the intake of a wine with high in vitro antioxidant activity decreased MDA and increased protein expression of SOD in the liver of rats fed a high-fat diet, while CAT and GPx activities were increased after the intake of a wine with low antioxidant activity [51]. More recently, red wine ethanolic extract was also shown to attenuated the levels of lipid peroxides induced by a high-fat diet in rats [52].…”

Section: Discussionmentioning

confidence: 68%

Comparison between red wine and isolated trans-resveratrol on the prevention and regression of atherosclerosis in LDLr (−/−) mice

Chassot

Scolaro

Roschel

et al. 2018

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

Moderate consumption of red wine has been widely associated with reduced cardiovascular risk, mainly due to its composition in phenolic compounds with antioxidant activity, such as resveratrol. The objective of this study was to compare the effect of red wine vs. trans-resveratrol consumption on the prevention and regression of atherosclerosis in LDLr mice. This study consisted of two protocols: "Prevention" (PREV) and "Regression" (REGR). Both protocols included four groups: red wine (WINE), dealcoholized red wine (EXT), trans-resveratrol (RESV), and control (CONT). In PREV protocol, animals received a regular diet for 8 weeks and then switched to an atherogenic diet for the following 8 weeks, while the opposite was performed in REGR. Animals that received atherogenic diet after an initial period of standard diet (PREV) gained more body weight (39.25±2.30%) than the opposite (29.27±1.91%, P=.0013), suggesting an interaction between age and weight gain. Trans-resveratrol showed the highest hypocholesterolemic effect during PREV, reducing total cholesterol, LDL-C, VLDL-C and HDL-C. Supplementation with trans-resveratrol and dealcoholized red wine changed the fatty acids profile in the liver in both protocols, leading to an increase of MDA concentrations and SOD activity in the PREV protocol. In conclusion, supplementation with trans-resveratrol, red wine and the same wine without alcohol altered biomarkers of oxidative stress and lipidemia but had no effect on the prevention or regression of fatty streaks. These data suggest that cardiovascular protection associated with the "French Paradox" may be a result of synergistic effects between wine and the Mediterranean diet.

show abstract

Section: Discussionmentioning

confidence: 68%

Comparison between red wine and isolated trans-resveratrol on the prevention and regression of atherosclerosis in LDLr (−/−) mice

Chassot

Scolaro

Roschel

et al. 2018

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

show abstract

“…The liver plays a central role in all the steps of lipid and energy metabolism, and some of the enzymes involved in these pathways are modulated by RedOx status. In this context, dietary polyphenols are able to modulate triglyceride accumulation, by regulating expression and/or activity of proteins associated with lipid homeostasis and metabolism . In addition, it was demonstrated that the plant flavonol quercetin enhances hepatic mitochondrial oxidative metabolism via Peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha (PGC‐1α)—a known modulator of mitochondrial biogenesis/energy production—downstream the activation of the Nrf2/HO‐1 pathway.…”

Section: Introductionmentioning

confidence: 99%

Prunus Mahaleb Fruit Extract Prevents Chemically Induced Colitis and Enhances Mitochondrial Oxidative Metabolism via the Activation of the Nrf2 Pathway

Ferramosca

Treppiccione

Giacomo

et al. 2019

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Scope Polyphenols exhibit their antioxidant activity downstream the activation of the nuclear factor erythroid 2‐related factor 2 pathway (Nrf2), but the connection between lipid metabolism and the Nrf2 pathway is still unknown. Flavonoid‐rich concentrated extract from Prunus mahaleb (mahaleb concentrated fruit extract; MCFE) may act on oxido‐reductive homeostasis and hepatic lipid metabolism via Nrf2. Methods & Results MCFE ability to enhance the activity of Nrf2‐mediated antioxidant/detoxifying enzymes is investigated in liver and colon of BALB/c mice. After a 4‐week supplementation, macroscopic, histological, and biochemical signs of colitis are examined in mouse colon pulsed with 5% (w/v) dextran sodium sulfate (DSS). Untreated or DSS‐supplemented mice are used as negative or positive control. MCFE effect on liver lipid metabolism and its possible link with the Nrf2 pathway is investigated. MCFE intake increases antioxidant defenses in mice colon and its pretreatment blunts pathological signs of colitis, as compared to positive control. In the liver, the increase in antioxidant defenses is associated with enhanced oxidative metabolism and with higher levels of peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha (PGC‐1α) and of hemeoxygenase‐1 (HO‐1), in comparison with negative controls. Conclusion Cytoprotective and hypolipidemic effect produced by MCFE intake results, at least in part, by the activation of the Nrf2 pathway.

show abstract

“…All publications by Dal et al demonstrated the interest of the use of natural antioxidants (red wine polyphenols) to prevent and treat diseases with endothelial dysfunction related to oxidative stress [62,64,213,471,472]. Moreover, our recent works carried out on in vitro and in vivo models of metabolic disorders have allowed us not only to involve oxidative stress in the pathophysiology of disorders but also to demonstrate that natural antioxidant compounds help to prevent or reduce complications (polyphenols from green tea and red wine [442,473], red cabbage, Dal S, under publication). One study in process in the lab focusing on antioxidants in T1D seems be a new target for the diabetic optimization of management [474].…”

Section: Discussion and General Conclusionmentioning

confidence: 99%

The Protective Effect of Antioxidants Consumption on Diabetes and Vascular Complications

Dal

Sigrist

2016

Diseases

Self Cite

View full text Add to dashboard Cite

Obesity and diabetes is generally accompanied by a chronic state of oxidative stress, disequilibrium in the redox balance, implicated in the development and progression of complications such as micro- and macro-angiopathies. Disorders in the inner layer of blood vessels, the endothelium, play an early and critical role in the development of these complications. Blunted endothelium-dependent relaxation and/or contractions are quietly associated to oxidative stress. Thus, preserving endothelial function and oxidative stress seems to be an optimization strategy in the prevention of vascular complications associated with diabetes. Diet is a major lifestyle factor that can greatly influence the incidence and the progression of type 2 diabetes and cardiovascular complications. The notion that foods not only provide basic nutrition but can also prevent diseases and ensure good health and longevity is now attained greater prominence. Some dietary and lifestyle modifications associated to antioxidative supply could be an effective prophylactic means to fight against oxidative stress in diabesity and complications. A significant benefit of phytochemicals (polyphenols in wine, grape, teas), vitamins (ascorbate, tocopherol), minerals (selenium, magnesium), and fruits and vegetables in foods is thought to be capable of scavenging free radicals, lowering the incidence of chronic diseases. In this review, we discuss the role of oxidative stress in diabetes and complications, highlight the endothelial dysfunction, and examine the impact of antioxidant foods, plants, fruits, and vegetables, currently used medication with antioxidant properties, in relation to the development and progression of diabetes and cardiovascular complications.

show abstract

Beneficial effects of a red wine polyphenol extract on high-fat diet-induced metabolic syndrome in rats

Abstract: RWPs showed an antioxidant mechanism of action against MS. This result will inform future animal studies exploring the metabolic effects of RWPs in more detail. In addition, these findings support the use of antioxidants as adjunctive nutritional treatments for patients with diabetes.

Cited by 16 publications

References 43 publications

Comparison between red wine and isolated trans-resveratrol on the prevention and regression of atherosclerosis in LDLr (−/−) mice

Comparison between red wine and isolated trans-resveratrol on the prevention and regression of atherosclerosis in LDLr (−/−) mice

Prunus Mahaleb Fruit Extract Prevents Chemically Induced Colitis and Enhances Mitochondrial Oxidative Metabolism via the Activation of the Nrf2 Pathway

The Protective Effect of Antioxidants Consumption on Diabetes and Vascular Complications

Contact Info

Product

Resources

About