Beneficial Effect on Average Lipid Levels From Energy Restriction and Fat Loss in Obese Individuals With or Without Type 2 Diabetes

Markovic, Tania; Campbell, Lesley V.; Balasubramanian, Santhira; Jenkins, A. B.; Fleury, A.C.; Simons, Leon A.; Chisholm, Donald J.

doi:10.2337/diacare.21.5.695

Cited by 52 publications

(31 citation statements)

References 29 publications

(36 reference statements)

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“…470,[472][473][474][475][476] Prevention of weight gain is therefore integral to the management of IGT and IFG. For such adults an attempt to lose weight is the fi rst-line dietary management goal in order to delay progression to type 2 diabetes.…”

Section: Weight Gain and Weight Lossmentioning

confidence: 99%

Absolute risk of cardiovascular disease events, and blood pressure‐ and lipid‐lowering therapy in Australia

Banks

Crouch

Korda

et al. 2016

Medical Journal of Australia

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Objective: To quantify absolute cardiovascular disease (CVD) risk and treatment in Australian adults. Design, participants: Cross‐sectional representative study of 9564 people aged 18 years or more who had participated in the 2011–12 Australian National Health Measures Survey (response rate for those aged 45–74 years: 46.5%). Main outcome measures: Prior CVD was ascertained and 5‐year absolute risk of a primary CVD event calculated (using the Australian National Vascular Disease Prevention Alliance algorithm; categories: low [< 10%], moderate [10–15%], and high [> 15%] risk) on the basis of data on medical history, risk factors and medications, derived from interviews, physical measurements, and blood and urine samples. Results: Absolute CVD risk increased with age and was higher among men than women. Overall, 19.9% (95% CI, 18.5–21.3%) of Australians aged 45–74 years had a high absolute risk of a future CVD event (an estimated 1 445 000 people): 8.7% (95% CI, 7.8–9.6%) had prior CVD (estimated 634 000 people) and 11.2% (95% CI, 10.2–12.2%) had high primary CVD risk (estimated 811 000 people). A further 8.6% (95% CI, 7.4–9.8%, estimated 625 000) were at moderate primary CVD risk. Among those with prior CVD, 44.2% (95% CI, 36.8–51.6%) were receiving blood pressure‐ and lipid‐lowering medications, 35.4% (95% CI, 27.8–43.0%) were receiving only one of these, and 20.4% (95% CI, 13.9–26.9%) were receiving neither. Corresponding figures for high primary CVD risk were 24.3% (95% CI, 18.3–30.3%); 28.7% (95% CI, 22.7–34.7%); and 47.1% (95% CI, 39.9–54.3%). Conclusions: About one‐fifth of the Australian population aged 45–74 years (about 1.4 million individuals) were estimated to have a high absolute risk of a future CVD event. Most (estimated 970 000) were not receiving currently recommended combination blood pressure‐ and lipid‐lowering therapy, indicating substantial potential for health gains by increasing routine assessment and treatment according to absolute CVD risk.

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Section: Weight Gain and Weight Lossmentioning

confidence: 99%

Absolute risk of cardiovascular disease events, and blood pressure‐ and lipid‐lowering therapy in Australia

Banks

Crouch

Korda

et al. 2016

Medical Journal of Australia

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“…Moderate amounts of weight loss, especially of intra-abdominal fat, reduce insulin resistance and help correct dyslipidemia (475,476). Intentional weight loss is also associated with reductions in mortality in overweight individuals with diabetes (477).…”

Section: Alcohol and Diabetesmentioning

confidence: 99%

“…This dyslipidemia is strongly associated with increased body adiposity that is abdominal (visceral) in distribution (622,623). Dietary fat restriction and weight loss will lead to decreased plasma triglycerides and a modest lowering of LDL cholesterol (300, 326,475). Regular physical activity also reduces plasma triglycerides (461,471,481) and improves insulin sensitivity (624).…”

Section: Hypertensionmentioning

confidence: 99%

Evidence-Based Nutrition Principles and Recommendations for the Treatment and Prevention of Diabetes and Related Complications

et al. 2002

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“…Chronic moderate reduction in energy intake results in the opposite effects, namely increased insulin sensitivity and improved glucose homeostasis (1)(2)(3). In fact, caloric restriction is considered as a common treatment for obesity, insulin resistance and type 2 diabetes (4).…”

Section: Introductionmentioning

confidence: 99%

Intermittent fasting modulation of the diabetic syndrome in sand rats. II. In vivo investigations

Belkacemi

Selselet‐Attou²,

Louchami³

et al. 2010

Int J Mol Med

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Abstract. This study deals with the effects of daily intermittent fasting for 15 h upon the development of diabetes in sand rats exposed to a hypercaloric diet. The same pattern of daily intermittent fasting was imposed on sand rats maintained on a purely vegetal diet (control animals). Over the last 30 days of the present experiments, non-fasting animals gained weight, whilst intermittently fasting sand rats lost weight. In this respect, there was no significant difference between control animals and either diabetic or non-diabetic sand rats exposed to the hypercaloric diet. The postprandial glycemia remained fairly stable in the control animals. During a 3-week transition period from a purely vegetal to a hypercaloric diet, the postprandial glycemia increased by 5.95±1.26 mM (n=6) in diabetic sand rats, as distinct from an increase of only 0.45±0.56 mM (n=6) in the non-diabetic animals. During the intermittent fasting period, the postprandial glycemia decreased significantly in the diabetic animals, but not so in the non-diabetic sand rats. Before the switch in food intake, the peak glycemia at the 30th min of an intraperitoneal glucose tolerance test was already higher in the diabetic than non-diabetic rats. In both the non-diabetic and diabetic sand rats, intermittent fasting prevented the progressive deterioration of glucose tolerance otherwise observed in non-fasting animals. These findings reveal that, at least in sand rats, intermittent daily fasting prevents the progressive deterioration of glucose tolerance otherwise taking place when these animals are exposed to a hypercaloric diet.

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Beneficial Effect on Average Lipid Levels From Energy Restriction and Fat Loss in Obese Individuals With or Without Type 2 Diabetes

Abstract: Even in obese subjects with an average lipid profile, modest weight loss reduces atherogenicity, independently of type 2 diabetes, and abdominal fat loss is specifically related to such improvements.

Cited by 52 publications

References 29 publications

Absolute risk of cardiovascular disease events, and blood pressure‐ and lipid‐lowering therapy in Australia

Absolute risk of cardiovascular disease events, and blood pressure‐ and lipid‐lowering therapy in Australia

Evidence-Based Nutrition Principles and Recommendations for the Treatment and Prevention of Diabetes and Related Complications

Intermittent fasting modulation of the diabetic syndrome in sand rats. II. In vivo investigations

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