Beneficial effect of the mitochondrial ATP‑sensitive potassium channel‑specific opener nicorandil on the collapsed lung via inhibition of apoptosis in clinical thoracic surgery

Wang, Chunguang; Wu, Ziyin; Li, Zhiqin; Wang, Zhichun; Ke, Honggang; Huang, Xinchong

doi:10.3892/mmr.2023.12948

Cited by 2 publications

(3 citation statements)

References 36 publications

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“…In fact, in the investigation of NICD’s organ protective effects, beyond the extensively studied AKI and ALI posited in this research, there exist additional studies that demonstrate the potential for NICD to protect the lungs and brain. 29 , 30 Animal experiments have revealed that NICD could mitigate ischemic reperfusion injury in isolated rat lungs. In addition, another clinical study has demonstrated that NICD could provide lung protection in patients undergoing thoracic surgery who require lung collapse techniques by inhibiting apoptosis.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Perioperative Nicorandil on Myocardial Protection in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass, a Retrospective Study

Chen,

Liu,

et al. 2024

DDDT

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Background The potential myocardial protective effect of nicorandil (NICD) in patients undergoing percutaneous coronary intervention has been established. However, its efficacy in the context of cardiac surgery remains controversial. The present study aimed to evaluate the myocardial protective effect of perioperative NICD use in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Methods We retrospectively gathered data from patients undergoing cardiac bypass surgery between 12/2018 and 04/2021 in Fuwai Hospital. Subsequently, the patients were divided into two groups, NICD group and non-nicorandil (non-NICD) group. A 1, 3 propensity score matching (PSM) was conducted. The primary outcome was the incidence of myocardial injury. The secondary outcomes included the mechanical ventilation (MV) duration, intensive care unit (ICU) length of stay (LOS), hospital LOS, duration of chest drainage, the drainage volume, the total cost, the incidence of acute kidney injury (AKI), and the incidence of acute liver injury (ALI). Subsequently, we divided the entire population into two distinct subgroups based on their administration of NICD, and performed a comprehensive subgroup analysis. Results A total of 2406 patients were ultimately included in the study. After PSM, 250 patients in NICD group and 750 patients in non-NICD group were included in the analysis. Perioperative NICD reduced the incidence of myocardial injury (47.2% versus 38.8%, P=0.025). Our subgroup analysis revealed that preoperative NICD administration not only provided myocardial protection benefits (45.7% vs 35.8%, OR 0.66, 95% CI [0.45–0.97], P=0.041), but also demonstrated statistically significant reduction in ALI, the ICU and hospital LOS, and the duration of chest drainage (all P<0.05). Conclusion The perioperative NICD administration may confer myocardial protection in patients undergoing cardiac surgery with CPB. Furthermore, the preoperative utilization of NICD has the potential to mitigate the incidence of postoperative ALI, a reduction in the ICU and hospital LOS, and the duration of chest drainage.

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Section: Discussionmentioning

confidence: 99%

“…In fact, in the investigation of NICD's organ protective effects, beyond the extensively studied AKI and ALI posited in this research, there exist additional studies that demonstrate the potential for NICD to protect the lungs and brain. 29,30…”

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confidence: 99%

Effect of Perioperative Nicorandil on Myocardial Protection in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass, a Retrospective Study

Chen,

Liu,

et al. 2024

DDDT

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“…Although both of these drugs act as potassium channel openers, they may have different effects due to their distinct chemical structures. Numerous studies in recent years have demonstrated that drugs within the same group, routinely used today, can exhibit different therapeutic and side effects [23][24][25][26][27]. Therefore, it is evident that these two drugs, being part of the same group, may not always produce identical effects.…”

Section: Discussionmentioning

confidence: 99%

Nicorandil mitigates glutamate excitotoxicity in primary cultured neurons

Ertugrul,

Okkay,

Yeni

et al. 2024

Med-Science

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Excitotoxicity, caused by the excessive release of glutamate, leads to the activation of the apoptotic process, making it a crucial factor in age-related neurodegenerative diseases. The aim of this study was to investigate the potential of nicorandil to prevent glutamate excitotoxicity and reduce oxidative stress in the brain by analyzing the effects of nicorandil on primary cortex neurons. The study used primary neuron cultures from newborn Sprague-Dawley rats to examine the impact of nicorandil on cell viability, Superoxide Dismutase, Catalase, Glutathione activity, Malondialdehyde levels, total antioxidant capacity, and total antioxidant status of neurons subjected to glutamate-induced excitotoxicity. Nicorandil at varying concentrations was introduced in the culture to assess its protective effects on the neurons. The results showed that nicorandil significantly improved cell viability and total antioxidant capacity levels and reduced total antioxidant status values in a concentration-dependent manner. These findings indicate that nicorandil effectively prevented glutamate excitotoxicity by reducing oxidative stress. The study suggests that nicorandil holds the potential for treating neurodegenerative diseases caused by glutamate excitotoxicity. This study is the first to report the potential of nicorandil to inhibit oxidative stress and prevent glutamate excitotoxicity in primary neurons, providing a basis for further exploration of the clinical application of nicorandil in neurodegenerative diseases.

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Beneficial effect of the mitochondrial ATP‑sensitive potassium channel‑specific opener nicorandil on the collapsed lung via inhibition of apoptosis in clinical thoracic surgery

Cited by 2 publications

References 36 publications

Effect of Perioperative Nicorandil on Myocardial Protection in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass, a Retrospective Study

Effect of Perioperative Nicorandil on Myocardial Protection in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass, a Retrospective Study

Nicorandil mitigates glutamate excitotoxicity in primary cultured neurons

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