Beneficial effect of tamsulosin combined with dapoxetine in management of type III prostatitis with premature ejaculation

Abstract

To evaluate the efficacy and safety of tamsulosin combined with dapoxetine in the treatment of type IIIB chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) that is complicated by premature ejaculation (PE), a total of 251 CP/CPPS patients with PE were recruited from nine hospitals across China and were randomly divided into two groups: one received tamsulosin as a control, and the other received a combination therapy of tamsulosin and dapoxetine. Follow‐up was conducted at four time points, and indicators describing CP/CPPS and PE were compared between the two groups. In all, 223 patients were followed up at least once, and 114 patients completed all of the treatment process. The combination group showed more improvement in the symptoms of both PE and CP/CPPS, including thrust number (50.5 vs. 45), premature ejaculation profile score (11.39 vs. 6.96), intravaginal ejaculation latency time (5.95 min vs. 2.63 min) and the National Institutes of Health Chronic Prostatitis Symptom Index (7.44 vs. 11.81) in comparison with the tamsulosin group. In conclusion, for CP/CPPS patients with PE, tamsulosin combined with dapoxetine provided better therapeutic efficacy in the treatment of not only PE symptoms but also CP/CPPS indicators in comparison with tamsulosin monotherapy.

Efficacy and Safety of Extracorporeal Shock Wave Therapy in the Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome and Acquired Premature Ejaculation Patients

“…Smooth muscle contraction during ejaculation may increase the symptoms of CP. In addition, decreased pelvic region blood flow and ischemia in the pathophysiology of CP/CPPS cause damage to the nerves innervating the pelvic region, which may trigger PE [26]. In our study, it was observed that ESWT treatment reduced pain in the pelvic region, reduced LUTS, and improved both erectile functions and PE symptoms in LUTS, as it provided the regeneration of nerves in the pelvic region.…”

“…Previously, treatments for PE due to CP/CPPS focused on classical antibiotic, anti-inflammatory, and alpha- blocker treatments. One study showed that the use of dapoxetine in combination with the alpha-blocker tamsulosin had a significant curative effect on IELT and PEP scores [26].…”

Oral pharmacological treatments for chronic prostatitis/chronic pelvic pain syndrome: A systematic review and network meta-analysis of randomised controlled trials

“…Following abstract screening and full-text reviews, 25 randomised controlled trials involving 3514 patients with CP/CPPS were included ( Figure 1 ). 9 , 24 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 Overall, the studies were conducted between 1999 and 2019. For the analysis, we compared 18 monotherapies, six combination therapies and placebo.…”

Systematic review and meta-analysis: α-adrenergic receptor blockers in chronic prostatitis

“…The excitability of the bladder neck, urethra, and smooth muscle of the prostate can be selectively inhibited by α-adrenergic receptor blockers (α-ARBs), which can reduce the obstruction of the position of the urethra by promoting muscle relaxation and alleviating urethral obstruction (5,6). In recent years, the effects of α-ARBs such as alfurazosin, tamsulosin, and terazosin in the treatment of type III Original Article Systematic review and meta-analysis: α-adrenergic receptor blockers in chronic prostatitis prostatitis has been confirmed by many domestic and foreign scholars (7)(8)(9). However, current clinical studies on the treatment of CP with α-ARBs have different results and are of varying quality, using different scales and measuring different effects.…”