Beneficial Effect of Kidney Bean Resistant Starch on Hyperlipidemia—Induced Acute Pancreatitis and Related Intestinal Barrier Damage in Rats

Abstract

Accumulating attention has been focused on resistant starch (RS) due to its blood-lipid-lowering activities. However, reports on the potential bioactivities of RS for preventing hyperlipidemia acute pancreatitis (HLAP) are limited. Therefore, in this study, an acute pancreatitis model was set up by feeding a hyperlipidemia diet to rats, and subsequently evaluating the anti-HLAP effect of RS in kidney beans. The results show that the IL-6, IL-1β, and TNF-α of serum in each RS group were decreased by 18.67–50.00%, 7.92–22.89%, and 8.06–34.04%, respectively, compared with the model group (MOD). In addition, the mRNA expression of tight junction protein ZO-1, occludin, and antibacterial peptides CRAMP and DEFB1 of rats in each RS group increased by 26.43–60.07%, 229.98–279.90%, 75.80–111.20%, and 77.86–109.07%, respectively. The height of the villi in the small intestine and the thickness of the muscle layer of rats were also increased, while the depth of the crypt decreased. The present study indicates that RS relieves intestinal inflammation, inhibits oxidative stress, and prevents related intestinal barrier damage. These results support the supplementation of RS as an effective nutritional intervention for HLAP and associated intestinal injury.

Resistant starch in common beans: Concentration, characteristics, uses and health effects. A systematic map and review of the studies from 1962 to 2023

“…RS can strongly affect lipid metabolism by reducing many associated parameters (total cholesterol, triglycerides, LDL, HDL, VLDL and IDL) (Hernandez-Velazquez et al, 2020). Common bean effect on hypercholesterolemia may be due also to its RS concentration, as also partly found by various authors modulating the presence of the RS from bean in model rats (Tanaka et al, 2019;Kilua et al, 2020;Zuo et al, 2022). Loader et al (2021) found scarce effect of various dies containing variable bean RS concentration on the body weight, blood pressure, and aorta morphology, but found a reduction of the fasting total cholesterol or low-density lipoprotein cholesterol International Journal of Food Science and Technology 2023 depending on either the bean cooking strategies and presence of bean in the diet.…”

“…RS can strongly affect lipid metabolism by reducing many associated parameters (total cholesterol, triglycerides, LDL, HDL, VLDL and IDL) (Hernandez‐Velazquez et al ., 2020). Common bean effect on hypercholesterolemia may be due also to its RS concentration, as also partly found by various authors modulating the presence of the RS from bean in model rats (Tanaka et al ., 2019; Kilua et al ., 2020; Zuo et al ., 2022). Loader et al .…”