Beneficial effect of
            <i>Chlorella pyrenoidosa</i>
            drink on healthy subjects: A randomized, placebo‐controlled, double‐blind, cross‐over clinical trial

Chiu, Hui‐Fang; Lee, Hsiao-Ju; Han, Yi‐Chun; Venkatakrishnan, Kamesh; Головинская, Оксана; Wang, Chin‐Kun

doi:10.1111/jfbc.13665

Cited by 7 publications

(4 citation statements)

References 32 publications

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“…To date, trials on humans are available for a few microalgae and are often based on dietary treatments for a few weeks. In this regard, some relevant findings are available for Phaeodactylum tricornutum (Bacillariophyta) [256], species of the genus Chlorella (Trebouxiophyceae) [257][258][259][260][261][262], Haematococcus pluvialis (Chlorophyceae) [263][264][265][266], species of the genus Tetraselmis (Chlorodendrophyceae) [267], Euglena gracilis (Euglenophyceae) [268], species of the genus Nannochloropsis (Eustigmatophyceae) [269] and cyanobacteria of the genus Arthrospira (Cyanophyceae) [270,271].…”

Section: Figurementioning

confidence: 99%

Potential of Microalgae as Functional Foods Applied to Mitochondria Protection and Healthy Aging Promotion

Zanella

Vianello

2023

Nutraceuticals

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The rapid aging of the Western countries’ populations makes increasingly necessary the promotion of healthy lifestyles in order to prevent/delay the onset of age-related diseases. The use of functional foods can significantly help to achieve this aim, thanks to the contribution of biologically active compounds suitable to protect cellular and metabolic homeostasis from damage caused by stress factors. Indeed, the excessive production of reactive oxygen species (ROS), favored by incorrect eating and behavioral habits, are considered causal elements of oxidative stress, which in turn favors tissue and organism aging. Microalgae represent a convenient and suitable functional food because of their extraordinary ability to concentrate various active compounds, comprising omega-3 polyunsaturated fatty acids, sterols, phenolic compounds, carotenoids and others. Within cells, mitochondria are the cellular organelles most affected by the accumulation of molecular damage produced by oxidative stress. Since, in addition to producing the chemical energy for cellular metabolism, mitochondria control numerous cell cycle regulation processes, including intrinsic apoptosis, responses to inflammatory signals and other biochemical pathways, their dysfunction is considered decisive for many pathologies. Among these, some degenerative diseases of the nervous system, cardiovascular system, kidney function and even cancer are found. From this viewpoint, bioactive compounds of microalgae, in addition to possessing high antioxidant properties, can enhance mitochondrial functionality by modulating the expression of numerous protective factors and enzymes, which in turn regulate some essential biochemical pathways for the preservation of the functional integrity of the cell. Here, we summarize the current knowledge on the role played by microalgal compounds in the regulation of the mitochondrial life cycle, expression of protective and reparative enzymes, regulation of intrinsic apoptosis and modulation of some key biochemical pathways. Special attention was paid to the composition of some cultivable microalgae strains selected for their high content of active compounds suitable to protect and improve mitochondrial functions.

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Section: Figurementioning

confidence: 99%

Potential of Microalgae as Functional Foods Applied to Mitochondria Protection and Healthy Aging Promotion

Zanella

Vianello

2023

Nutraceuticals

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“…Several investigations have evaluated the effects of microalgae ingestion on DHEA. Chiu et al (2021), in a double-blind randomized clinical trial, observed increases in DHEA related to the intake of a Chlorella pyrenoidosa extract beverage in 44 healthy participants [44]. To the best of our knowledge, this is the only study evaluating the possible effects of a microalga on this hormone in a human organism.…”

Section: Discussionmentioning

confidence: 91%

Effects of Tetraselmis chuii Microalgae Supplementation on Anthropometric, Hormonal and Hematological Parameters in Healthy Young Men: A Double-Blind Study

García

Toro-Román

Siquier-Coll

et al. 2022

IJERPH

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The aim of this study was to evaluate the effects of Tetraselmis chuii (TC) microalgae supplementation for sixty days on hematological, anthropometric and hormonal parameters in healthy young men. Forty-six men divided into a placebo group (PG; n = 16; 20.77 ± 2.7 years; 72.14 ± 7.18 kg; 1.76 ± 0.07 m), a group supplemented with 25 mg/day of TC (SG 25; n = 15; 20.40 ± 1.40 years; 71.28 ± 8.26 kg; 1.76 ± 0.05 m) and another group supplemented with 200 mg/day of TC (SG 200; n = 15; 20.83 ± 2.45 years; 72.30 ± 11.13 kg; 1.77 ± 0.08 m) participated in this double-blind study. PG ingested 200 mg/day of lactose powder. Participants underwent 4 assessments (baseline, month 1, month 2 and desadaptation) separated in time by an interval of thirty days. At SG 25 and SG 200, significant increases in percent muscle mass, erythropoietin, insulin-like growth factor 1, free testosterone, leukocytes, neutrophils and lymphocytes were observed (p < 0.05). Decreases in the levels of percent fat mass, platelets, hematocrit and mean corpuscular hemoglobin also occurred in these groups (p < 0.05). TC supplementation induced favorable changes on anthropometric, hematological and hormonal levels. In view of the data, it seems that the most effective dose was 25 mg/day of TC.

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“…Interestingly, the Chlorella pyrenoidosa water extract showed anti-aging effects of Chlorella pyrenoidosa especially in the healthy individuals. The impacts were mediated by significantly downregulated inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and improved antioxidant levels (SOD, CAT TEAC, and DHEAs) and suppressed oxidative stress/aging markers (TBARS and 8-OHdG) in addition to protecting liver (reduced oxaloacetic transaminase and serum glutamic pyruvic transaminase) [ 68 ]. As per a clinical report, the daily consumption of chlorella can remarkably inhibit total cholesterol, very low-density lipoprotein cholesterol, apolipoprotein B, triglycerides, in mild hypercholesterolemic adults [ 69 ].…”

Section: Discussionmentioning

confidence: 99%

Exploring the therapeutic efficacy of Chlorella pyrenoidosa peptides in ameliorating Alzheimer's disease

Wang¹,

Chuu²,

Lee³

et al. 2023

Heliyon

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Beneficial effect of Chlorella pyrenoidosa drink on healthy subjects: A randomized, placebo‐controlled, double‐blind, cross‐over clinical trial

Cited by 7 publications

References 32 publications

Potential of Microalgae as Functional Foods Applied to Mitochondria Protection and Healthy Aging Promotion

Potential of Microalgae as Functional Foods Applied to Mitochondria Protection and Healthy Aging Promotion

Effects of Tetraselmis chuii Microalgae Supplementation on Anthropometric, Hormonal and Hematological Parameters in Healthy Young Men: A Double-Blind Study

Exploring the therapeutic efficacy of Chlorella pyrenoidosa peptides in ameliorating Alzheimer's disease

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