Beneficial Effect of H2−agonism and H1−antagonism in Rat Endotoxic Shock

Rixen, Dieter; Neugebauer, E.; Lechleuthner, A.; Buschauer, Armin; Nagelschmidt, M.; Thoma, Stefanie; Rink, Andreas D.

doi:10.1097/00024382-199407000-00010

Cited by 8 publications

(1 citation statement)

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“…Histamine has been proposed to play an important role in early inflammatory responses based on studies documenting elevated histamine levels in patients [1], effectiveness of histamine antagonists in acute inflammation [2][3][4], effects of histamine on vasodilatation and permeability of microvascular endothelium [5][6][7], and histamine enhancement of neuInflamm. res.…”

Section: Introductionmentioning

confidence: 99%

Polyclonal anti-histamine H 2 receptor antibodies detect differential expression of H 2 receptor protein in primary vascular cell types

Schneider

Rieß

Elbers

et al. 2004

Inflammation Research

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We conclude that the antibodies generated against the extra-cellular domain of the H2 receptor are specific and can be utilized to detect and quantify H2 receptor expression. Furthermore, the significant differences in H2 receptor expression in different vascular cell types might play a critical role in defining histamine induced cellular responses during physiological or pathophysiological processes.

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Section: Introductionmentioning

confidence: 99%

Polyclonal anti-histamine H 2 receptor antibodies detect differential expression of H 2 receptor protein in primary vascular cell types

Schneider

Rieß

Elbers

et al. 2004

Inflammation Research

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Histamin (H1 und H2) abhängige Veränderung der Neutrophilenadhäsion an humanen Endothelzellen

Schäfer

Schneider

Heß

et al. 1997

Chirurgisches Forum ’97 Für Experimentelle Und Klinische Forschung

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Acid-Suppressive Therapy and Risk of Infections: Pros and Cons

Fisher

2017

Clin Drug Investig

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This narrative review summarises the benefits, risks and appropriate use of acid-suppressing drugs (ASDs), proton pump inhibitors and histamine-2 receptor antagonists, advocating a rationale balanced and individualised approach aimed to minimise any serious adverse consequences. It focuses on current controversies on the potential of ASDs to contribute to infections-bacterial, parasitic, fungal, protozoan and viral, particularly in the elderly, comprehensively and critically discusses the growing body of observational literature linking ASD use to a variety of enteric, respiratory, skin and systemic infectious diseases and complications (Clostridium difficile diarrhoea, pneumonia, spontaneous bacterial peritonitis, septicaemia and other). The proposed pathogenic mechanisms of ASD-associated infections (related and unrelated to the inhibition of gastric acid secretion, alterations of the gut microbiome and immunity), and drug-drug interactions are also described. Both probiotics use and correcting vitamin D status may have a significant protective effect decreasing the incidence of ASD-associated infections, especially in the elderly. Despite the limitations of the existing data, the importance of individualised therapy and caution in long-term ASD use considering the balance of benefits and potential harms, factors that may predispose to and actions that may prevent/attenuate adverse effects is evident. A six-step practical algorithm for ASD therapy based on the best available evidence is presented.

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Beneficial Effect of H2−agonism and H1−antagonism in Rat Endotoxic Shock

Cited by 8 publications

References 0 publications

Polyclonal anti-histamine H 2 receptor antibodies detect differential expression of H 2 receptor protein in primary vascular cell types

Polyclonal anti-histamine H 2 receptor antibodies detect differential expression of H 2 receptor protein in primary vascular cell types

Histamin (H1 und H2) abhängige Veränderung der Neutrophilenadhäsion an humanen Endothelzellen

Acid-Suppressive Therapy and Risk of Infections: Pros and Cons

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